基金supported by grants from the National Natural Science Foundation of China (Nos.81471062,81471059, 81500660,and 81561128019)the Ministry of Science and Technology of China (Nos.2016YFC1305600,2016YFC1304904, and 2018YFC1311705)+1 种基金the National International Science Cooperation Foundation (No.2015DFA30560) the Gaofeng Clinical Medicine Grant Support of the Shanghai Municipal Education Commission (Nos.20152508and 20161301).