Huperzine A (1), a new Lycopodium alkaloid isolated from Chinese traditional medicine Huperzia Serrata, is a potent acetylcholinesterase inhibitor and a promising drug candidate of treating Alzheimer's disease as ...Huperzine A (1), a new Lycopodium alkaloid isolated from Chinese traditional medicine Huperzia Serrata, is a potent acetylcholinesterase inhibitor and a promising drug candidate of treating Alzheimer's disease as well. Several analogues of huperzine A, compound 8, 10, 14, 15 and 17were prepared and their inhibitory activities of acetylcholinesterase were evaluated展开更多
A new Lycopodium alkaloid huperzine A (1) possesses a potent inhibitory activity of acetylcholinesterase. Six structurally simplified analogues of huperzine A, compound 6, 7, 8, 12, 13 and 15, were prepared and the in...A new Lycopodium alkaloid huperzine A (1) possesses a potent inhibitory activity of acetylcholinesterase. Six structurally simplified analogues of huperzine A, compound 6, 7, 8, 12, 13 and 15, were prepared and the inhibitory activities were evaluated.展开更多
文摘Huperzine A (1), a new Lycopodium alkaloid isolated from Chinese traditional medicine Huperzia Serrata, is a potent acetylcholinesterase inhibitor and a promising drug candidate of treating Alzheimer's disease as well. Several analogues of huperzine A, compound 8, 10, 14, 15 and 17were prepared and their inhibitory activities of acetylcholinesterase were evaluated
文摘A new Lycopodium alkaloid huperzine A (1) possesses a potent inhibitory activity of acetylcholinesterase. Six structurally simplified analogues of huperzine A, compound 6, 7, 8, 12, 13 and 15, were prepared and the inhibitory activities were evaluated.
