Traumatic brain injury(TBI)is the main cause of disability,mental health disorder,and even death,with its incidence and social costs rising steadily.Although different treatment strategies have been developed and test...Traumatic brain injury(TBI)is the main cause of disability,mental health disorder,and even death,with its incidence and social costs rising steadily.Although different treatment strategies have been developed and tested to mitigate neurological decline,a definitive cure for these conditions remains elusive.Studies have revealed that vari-ous neurotrophins represented by the brain-derived neurotrophic factor are the key regulators of neuroinflammation,apoptosis,blood-brain barrier permeability,neurite regeneration,and memory function.These factors are instrumental in alleviating neu-roinflammation and promoting neuroregeneration.In addition,neural stem cells(NSC)contribute to nerve repair through inherent neuroprotective and immunomodulatory properties,the release of neurotrophins,the activation of endogenous NSCs,and in-tercellular signaling.Notably,innovative research proposals are emerging to combine BDNF and NSCs,enabling them to synergistically complement and promote each other in facilitating injury repair and improving neuron differentiation after TBI.In this review,we summarize the mechanism of neurotrophins in promoting neurogen-esis and restoring neural function after TBI,comprehensively explore the potential therapeutic effects of various neurotrophins in basic research on TBI,and investigate their interaction with NSCs.This endeavor aims to provide a valuable insight into the clinical treatment and transformation of neurotrophins in TBI,thereby promoting the progress of TBI therapeutics.展开更多
Recently our team investigated the energy deposition and excitation of wakefield in case of hundreds keV proton/helium ion beams passing a gas-discharged plasma target. The plasma target was produced by igniting an el...Recently our team investigated the energy deposition and excitation of wakefield in case of hundreds keV proton/helium ion beams passing a gas-discharged plasma target. The plasma target was produced by igniting an electric discharge of hydrogen gas in two-collinear quartz tubes, each of 5 mm in diameter and 78 mm in length, the electrical current even up to kA will flow in two opposite directions in either of the two quartz tubes.展开更多
针对目前方面级情感分析(ABSA)模型过多依赖关系较为稀疏的句法依赖树学习特征表示,导致模型学习局部信息能力不足的问题,提出了一种融合多窗口局部信息的ABSA模型MWGAT(combining Multi-Window local information and Graph ATtention ...针对目前方面级情感分析(ABSA)模型过多依赖关系较为稀疏的句法依赖树学习特征表示,导致模型学习局部信息能力不足的问题,提出了一种融合多窗口局部信息的ABSA模型MWGAT(combining Multi-Window local information and Graph ATtention network)。首先,通过多窗口局部特征学习机制学习局部上下文特征,并挖掘文本包含的潜在局部信息;其次,采用能够较好理解依赖树的图注意力网络(GAT)学习句法依赖树所表示的语法结构信息,并生成语法感知的上下文特征;最后,将这两种表示不同语义信息的特征融合,形成既包含句法依赖树的语法信息又包含局部信息的特征表示,从而便于分类器高效判别方面词的情感极性。在Restaurant、Laptop和Twitter这3个公开数据集上进行实验,结果表明与结合了句法依赖树的T-GCN(Type-aware Graph Convolutional Network)模型相比,所提模型的Macro-F1分数分别提高了2.48%、2.37%和0.32%。可见,所提模型能够有效挖掘潜在的局部信息,并更为精确地预测方面词的情感极性。展开更多
基金Laboratory Animal Foundation Program of Military,Grant/Award Number:SYDW[2018]01Promotion Plan of the Air Force Medical University,Grant/Award Number:2020SWAQ11Shaanxi Province Innovation Capability Support Plan,Grant/Award Number:2021PT-037。
文摘Traumatic brain injury(TBI)is the main cause of disability,mental health disorder,and even death,with its incidence and social costs rising steadily.Although different treatment strategies have been developed and tested to mitigate neurological decline,a definitive cure for these conditions remains elusive.Studies have revealed that vari-ous neurotrophins represented by the brain-derived neurotrophic factor are the key regulators of neuroinflammation,apoptosis,blood-brain barrier permeability,neurite regeneration,and memory function.These factors are instrumental in alleviating neu-roinflammation and promoting neuroregeneration.In addition,neural stem cells(NSC)contribute to nerve repair through inherent neuroprotective and immunomodulatory properties,the release of neurotrophins,the activation of endogenous NSCs,and in-tercellular signaling.Notably,innovative research proposals are emerging to combine BDNF and NSCs,enabling them to synergistically complement and promote each other in facilitating injury repair and improving neuron differentiation after TBI.In this review,we summarize the mechanism of neurotrophins in promoting neurogen-esis and restoring neural function after TBI,comprehensively explore the potential therapeutic effects of various neurotrophins in basic research on TBI,and investigate their interaction with NSCs.This endeavor aims to provide a valuable insight into the clinical treatment and transformation of neurotrophins in TBI,thereby promoting the progress of TBI therapeutics.
文摘Recently our team investigated the energy deposition and excitation of wakefield in case of hundreds keV proton/helium ion beams passing a gas-discharged plasma target. The plasma target was produced by igniting an electric discharge of hydrogen gas in two-collinear quartz tubes, each of 5 mm in diameter and 78 mm in length, the electrical current even up to kA will flow in two opposite directions in either of the two quartz tubes.
文摘针对目前方面级情感分析(ABSA)模型过多依赖关系较为稀疏的句法依赖树学习特征表示,导致模型学习局部信息能力不足的问题,提出了一种融合多窗口局部信息的ABSA模型MWGAT(combining Multi-Window local information and Graph ATtention network)。首先,通过多窗口局部特征学习机制学习局部上下文特征,并挖掘文本包含的潜在局部信息;其次,采用能够较好理解依赖树的图注意力网络(GAT)学习句法依赖树所表示的语法结构信息,并生成语法感知的上下文特征;最后,将这两种表示不同语义信息的特征融合,形成既包含句法依赖树的语法信息又包含局部信息的特征表示,从而便于分类器高效判别方面词的情感极性。在Restaurant、Laptop和Twitter这3个公开数据集上进行实验,结果表明与结合了句法依赖树的T-GCN(Type-aware Graph Convolutional Network)模型相比,所提模型的Macro-F1分数分别提高了2.48%、2.37%和0.32%。可见,所提模型能够有效挖掘潜在的局部信息,并更为精确地预测方面词的情感极性。
