肥胖蛋白(fat mass and obesity-associated protein,FTO)是一种RNA去甲基化酶,其与α-酮戊二酸加氧酶如AlkB同源家族(ALKBH)蛋白具有序列同源性,在m6A修饰方面发挥重要作用,可以调节RNA代谢的许多过程,包括降解和翻译等。越来越多的研...肥胖蛋白(fat mass and obesity-associated protein,FTO)是一种RNA去甲基化酶,其与α-酮戊二酸加氧酶如AlkB同源家族(ALKBH)蛋白具有序列同源性,在m6A修饰方面发挥重要作用,可以调节RNA代谢的许多过程,包括降解和翻译等。越来越多的研究表明,FTO参与调控神经发生、多巴胺信号传导和食欲调节、脂肪发生、致癌和病毒感染等生物学过程。本文主要对FTO的结构与功能、在肿瘤中的作用机制,及其抑制剂进行综述。展开更多
Metal–organic-framework(MOF)has been an increasingly hot organic-inorganic hybrid compounds. Here we develop an innovative concept by engineering a supporting layer made of MOF derived carbon materials. The supportin...Metal–organic-framework(MOF)has been an increasingly hot organic-inorganic hybrid compounds. Here we develop an innovative concept by engineering a supporting layer made of MOF derived carbon materials. The supporting thin layer is prepared by carbonizing zeolitic-imidazole framework(ZIF-67). CdSe quantum dot sensitized TiO_2 nanocrystalline thin film deposited by the method of chemical bath deposition(CBD). The MOF unique microstructure in the support layer builds the electronic highway, which greatly improves the efficiency of the CdSe quantum dot-sensitized solar cells(QDSSCs), and the power conversion efficiency(PCE)of the device was significantly improved from 2.98% to 5.79% via ZIF-67 derived carbon supporting thin layer.展开更多
文摘肥胖蛋白(fat mass and obesity-associated protein,FTO)是一种RNA去甲基化酶,其与α-酮戊二酸加氧酶如AlkB同源家族(ALKBH)蛋白具有序列同源性,在m6A修饰方面发挥重要作用,可以调节RNA代谢的许多过程,包括降解和翻译等。越来越多的研究表明,FTO参与调控神经发生、多巴胺信号传导和食欲调节、脂肪发生、致癌和病毒感染等生物学过程。本文主要对FTO的结构与功能、在肿瘤中的作用机制,及其抑制剂进行综述。
文摘Metal–organic-framework(MOF)has been an increasingly hot organic-inorganic hybrid compounds. Here we develop an innovative concept by engineering a supporting layer made of MOF derived carbon materials. The supporting thin layer is prepared by carbonizing zeolitic-imidazole framework(ZIF-67). CdSe quantum dot sensitized TiO_2 nanocrystalline thin film deposited by the method of chemical bath deposition(CBD). The MOF unique microstructure in the support layer builds the electronic highway, which greatly improves the efficiency of the CdSe quantum dot-sensitized solar cells(QDSSCs), and the power conversion efficiency(PCE)of the device was significantly improved from 2.98% to 5.79% via ZIF-67 derived carbon supporting thin layer.
