The band structure and transmission coefficient of the two-dimensional ternary locally resonant phononic crystal are computed by the finite element method with the calculated frequency up to 120 kHz.The band gap in th...The band structure and transmission coefficient of the two-dimensional ternary locally resonant phononic crystal are computed by the finite element method with the calculated frequency up to 120 kHz.The band gap in the high frequency range is found and considered as the Bragg band gap in the locally resonant phononic crystal which has the locally resonant band gap in the low frequency range normally.Then,a composite phononic crystal by hybridizing the Bragg scattering phononic crystal and the locally resonant phononic crystal is proposed.Simultaneous Bragg and locally resonant band gaps are displayed and discussed for the composite phononic crystal.The results show that the simultaneous Bragg band gap and locally resonant band gap can be tuned.展开更多
Objective To explore the effect of electroacupuncture(EA)intervention on the vasoconstriction of cerebral artery smooth muscle cells after cerebral infarction.Methods Male Wistar rats were randomly divided into 3 grou...Objective To explore the effect of electroacupuncture(EA)intervention on the vasoconstriction of cerebral artery smooth muscle cells after cerebral infarction.Methods Male Wistar rats were randomly divided into 3 groups by a random number table:the model group(n=24),the EA group(n=24),and the normal group(n=6).The model and the EA groups were divided into different time subgroups at 0.5,1,3,and 6 h after middle cerebral artery occlusion(MCAO),with 6 rats in each subgroup.MCAO model was established using intraluminal suture occlusion method.The EA group was given EA treatment at acupoint Shuigou(GV 26)instantly after MCAO for 20 min.The contents of cerebrovascular smooth muscle MLCK,the 3 subunits of myosin light chain phosphatase(MLCP)MYPT1,PP1c-δand M20,as well as myosin-ATPase activity were detected using immunohistochemistry and Western blotting.Results The overall expression level of the MYPT1 and PP1c-δin the model group was significantly higher(P<0.01).After EA intervention,the 0.5 h group expression level was close to that of the normal group(P>0.05),and the other subgroups were still significantly higher than the normal group(P<0.01).After EA intervention,the expression level of each subgroup was significantly lower than the corresponding model group.There was a significant difference between the 0.5 and 1 h subgroups(P<0.01),while a difference was also observed between the 3 and 6 h subgroups(P<0.05).The dynamic change rule gradually increased with the prolongation of infarction time within 6 h after infarction.Conclusion EA intervention can inhibit contraction of cerebral vascular smooth muscle cells and regulate smooth muscle relaxation by regulating MLCK pathway.展开更多
基金the National Natural Science Foundation of China(Nos 10832002 and 11072127)the National Basic Research Program of China(No 2011CB610305).
文摘The band structure and transmission coefficient of the two-dimensional ternary locally resonant phononic crystal are computed by the finite element method with the calculated frequency up to 120 kHz.The band gap in the high frequency range is found and considered as the Bragg band gap in the locally resonant phononic crystal which has the locally resonant band gap in the low frequency range normally.Then,a composite phononic crystal by hybridizing the Bragg scattering phononic crystal and the locally resonant phononic crystal is proposed.Simultaneous Bragg and locally resonant band gaps are displayed and discussed for the composite phononic crystal.The results show that the simultaneous Bragg band gap and locally resonant band gap can be tuned.
基金Supported by the National Natural Science Foundation of China(Nos.81674056 and 82074543)the Tianjin Municipal Natural Science Foundation(No.18JCYBJC94200),China。
文摘Objective To explore the effect of electroacupuncture(EA)intervention on the vasoconstriction of cerebral artery smooth muscle cells after cerebral infarction.Methods Male Wistar rats were randomly divided into 3 groups by a random number table:the model group(n=24),the EA group(n=24),and the normal group(n=6).The model and the EA groups were divided into different time subgroups at 0.5,1,3,and 6 h after middle cerebral artery occlusion(MCAO),with 6 rats in each subgroup.MCAO model was established using intraluminal suture occlusion method.The EA group was given EA treatment at acupoint Shuigou(GV 26)instantly after MCAO for 20 min.The contents of cerebrovascular smooth muscle MLCK,the 3 subunits of myosin light chain phosphatase(MLCP)MYPT1,PP1c-δand M20,as well as myosin-ATPase activity were detected using immunohistochemistry and Western blotting.Results The overall expression level of the MYPT1 and PP1c-δin the model group was significantly higher(P<0.01).After EA intervention,the 0.5 h group expression level was close to that of the normal group(P>0.05),and the other subgroups were still significantly higher than the normal group(P<0.01).After EA intervention,the expression level of each subgroup was significantly lower than the corresponding model group.There was a significant difference between the 0.5 and 1 h subgroups(P<0.01),while a difference was also observed between the 3 and 6 h subgroups(P<0.05).The dynamic change rule gradually increased with the prolongation of infarction time within 6 h after infarction.Conclusion EA intervention can inhibit contraction of cerebral vascular smooth muscle cells and regulate smooth muscle relaxation by regulating MLCK pathway.
