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云木香提取物通过调节Bax/Bcl-2蛋白的表达对大鼠胃黏膜产生保护作用 被引量:5
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作者 雷娜 陈纭 +4 位作者 张凯玲 朱昊 许苑南 郭沛鑫 解宇环 《中国临床药理学与治疗学》 CAS CSCD 2021年第12期1370-1378,共9页
目的:探讨云木香乙醇提取物(ethanol extract of costusroot,EEC)对胃溃疡模型大鼠胃黏膜的影响及相关机制。方法:将SD大鼠随机分组:正常组、模型组、硫糖铝组、EEC低、高剂量组,除正常组外其余各组大鼠灌胃无水乙醇复制胃溃疡模型。观... 目的:探讨云木香乙醇提取物(ethanol extract of costusroot,EEC)对胃溃疡模型大鼠胃黏膜的影响及相关机制。方法:将SD大鼠随机分组:正常组、模型组、硫糖铝组、EEC低、高剂量组,除正常组外其余各组大鼠灌胃无水乙醇复制胃溃疡模型。观察各组大鼠胃溃疡面积变化并计算溃疡抑制率;HE染色法观测胃组织病理形态学改变;采用免疫组化法(immunohistochemisty,IHC)和Western blot法检测胃溃疡大鼠胃组织中Bax、Bcl-2蛋白的表达水平。结果:EEC能有效抑制模型大鼠溃疡面积的形成,减轻乙醇引起的胃组织病理学损伤;上调胃溃疡大鼠胃组织中Bcl-2蛋白表达(P<0.01),有效抑制乙醇引起的Bax蛋白过量表达(P<0.01)。结论:EEC具有良好的抗胃溃疡作用,其作用机制可能与调节Bax、Bcl-2蛋白表达水平抑制胃黏膜细胞凋亡有关。 展开更多
关键词 云木香 胃黏膜 胃溃疡 BAX BCL-2
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基于FlightSim和PyQt的电视制导系统仿真
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作者 侯成林 许元男 +1 位作者 陈万春 孟偲 《飞行力学》 CSCD 北大核心 2024年第5期89-94,共6页
针对电视制导系统仿真中简化的导引头模型精度和逼真程度不足的问题,提出了一种考虑图像处理过程的电视制导系统仿真方法。首先,利用FlightSim软件实现导弹的动力学仿真并实时生成三维场景;然后,采用PyQt库封装导引头图像处理过程并创... 针对电视制导系统仿真中简化的导引头模型精度和逼真程度不足的问题,提出了一种考虑图像处理过程的电视制导系统仿真方法。首先,利用FlightSim软件实现导弹的动力学仿真并实时生成三维场景;然后,采用PyQt库封装导引头图像处理过程并创建用于“人在回路”交互的GUI;最后,通过接口函数和Socket建立FlightSim程序与PyQt程序之间的通信。仿真结果表明,该系统能够逼真地模拟带有图像处理环节的电视制导过程,具有较好的应用价值。 展开更多
关键词 电视制导 图像处理 FlightSim PyQt
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Effect and mechanism of ethanol extracts of muxiang(Radix Aucklandiae) on gastric ulcers in rats 被引量:3
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作者 xu yuannan Guo Peixin +7 位作者 Wang Yulian Xia Tingting Shen Yue Zhang Qing Huang Jinhong Chen Haifeng Lei Na Xie Yuhuan 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2020年第1期59-66,共8页
OBJECTIVE:To investigate the effect of ethanol extracts of Muxiang(Radix Aucklandiae)(RA)on gastric ulcers in rats and explore the potential mechanisms.METHODS:A model was established by ethanol(0.75 m L/kg).According... OBJECTIVE:To investigate the effect of ethanol extracts of Muxiang(Radix Aucklandiae)(RA)on gastric ulcers in rats and explore the potential mechanisms.METHODS:A model was established by ethanol(0.75 m L/kg).According to body weight,rats were pretreated with RA extracts(2.5 or 5 g/kg).The rats were administered 95%ethanol orally after 1 h.The effects of ethanol were evaluated by measuring the gastric secretion volume,p H,pepsin activity,and ulcer area.Histological analysis and immunohistochemistry were also conducted.Furthermore,the effect of the ethanol extract of RA on transiting activity of the gastrointestinal tract was observed in mice.RESULTS:Intragastric administration of RA extracts protected the gastric mucosa from ethanol-induced gastric ulcers,while reducing submucosal edema and preventing hemorrhagic damage.Moreover,the extracts increased the production of gastric mucus,upregulated Bcl-2,and downregulated Bax expression.Importantly,pretreated rats exhibited no significant change in the gastric secretion volume,gastric juice acidity,or pepsin.Furthermore,pretreatment prominently(P<0.05)enhanced propulsive movement of the gastrointestinal tract in normal mice and mice with gastrointestinal motility disorders.CONCLUSION:Ethanol extracts of RA ameliorated gastric lesions in the gastric ulcer rat model.The mechanisms of action were related to improvement of gastrointestinal dynamics,maintenance of mucus integrity,and inhibition of apoptosis by downregulating proapoptotic Bax protein and upregulating anti-apoptotic Bcl-2 protein. 展开更多
关键词 STOMACH ULCER GASTRIC MUCOSA Apoptosis Genes Bcl-2 GASTROINTESTINAL dynamics Muxiang(Radix Aucklandiae)
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