Eight novel neonicotinoids N-oxide analogues were designed and synthesized. All the compounds have been identified by 1H NMR and HRMS. The N-oxide analogues exhibit high insecticidal activity against cowpea aphids （A...Eight novel neonicotinoids N-oxide analogues were designed and synthesized. All the compounds have been identified by 1H NMR and HRMS. The N-oxide analogues exhibit high insecticidal activity against cowpea aphids （Aphis craccivora） at 250 mg,L-1. The influence of N-oxide formation on the biological activity was elucidated by computational chemical study, and it indicated that the water bridge hydrogen bonding network was broken due to the influence of the O atom connected with the pyridine ring.展开更多
基金This work was financially supported by National Basic Research Program of China （973 Program, 2010CB126100）, National High Technology Research and Development Program of China （863 Program, 2011AA10A207）. This work was also partly supported by National Key Technology R＆D Program of China （2011BAE06B01）, National Natural Science Foundation of China （20802018）, Shanghai Foundation of Science and Technology （09391911800, 08391911600, 08ZR1406500）, Doctoral Program of Higher Education （200802511002）, Shanghai Leading Academic Discipline Project, Project Number： B507 and the Fundamental Research Funds for the Central Universities. This work was supported by ＂Special Fund for Agro-scientific Research in the Public Interest （201103007）＂.
文摘Eight novel neonicotinoids N-oxide analogues were designed and synthesized. All the compounds have been identified by 1H NMR and HRMS. The N-oxide analogues exhibit high insecticidal activity against cowpea aphids （Aphis craccivora） at 250 mg,L-1. The influence of N-oxide formation on the biological activity was elucidated by computational chemical study, and it indicated that the water bridge hydrogen bonding network was broken due to the influence of the O atom connected with the pyridine ring.
