Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022

BACKGROUND Gastrointestinal neoplasm(GN)significantly impact the global cancer burden and mortality,necessitating early detection and treatment.Understanding the evolution and current state of research in this field is vital.AIM To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research,focusing on key contributors,institutions,and thematic evolution.METHODS This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the"bibliometrix"R package,VOSviewer,and CiteSpace.The analysis focused on the distribution of publications,contributions by institutions and countries,and trends in keywords.The methods included data synthesis,network analysis,and visualization of international collaboration networks.RESULTS This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and collaboration.It highlights the United States'critical role in advancing this field,with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer Institute.The last five years,substantial advancements have been made,representing nearly 45%of the examined literature.Publication rates have dramatically increased,from 20 articles in 2002 to 112 in 2022,reflecting intensified research efforts.This study underscores a growing trend toward interdisciplinary and international collaboration,with the Journal of Clinical Oncology standing out as a key publication outlet.This shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN risks.CONCLUSION This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research emphasis.This calls for enhanced global collaboration and integration of artificial intelligence to improve cancer prevention and treatment accuracy,ultimately enhancing worldwide patient care.

Chest CT features of children infected by B.1.617.2 (Delta) variant of COVID‑19

Background This study aimed to explore the imaging characteristics,diversity and changing trend in CT scans of pediatric patients infected with Delta-variant strain by studying imaging features of children infected with Delta and comparing the results to those of children with original COVID-19.Methods A retrospective,comparative analysis of initial chest CT manifestations between 63 pediatric patients infected with Delta variant in 2021 and 23 pediatric patients with COVID-19 in 2020 was conducted.Corresponding imaging features were analyzed.In addition,the changing trend in imaging features of COVID-19 Delta-variant cases were explored by evaluating the initial and follow-up CT scans.Results Among 63 children with Delta-variant COVID-19 in 2021,34(53.9%)showed positive chest CT presentation;and their CT score(1.10±1.41)was signifcantly lower than that in 2020(2.56±3.5)(P=0.0073).Lesion distribution:lung lesions of Delta cases appear mainly in the lower lungs on both sides.Most children had single lobe involvement(18 cases,52.9%),14(41.2%)in the right lung alone,and 14(41.2%)in both lungs.A majority of Delta cases displayed initially ground glass(23 cases,67.6%)and nodular shadows(13 cases,38.2%)in the frst CT scan,with few extrapulmonary manifestations.The 34 children with abnormal chest CT for the frst time have a total of 92 chest CT examinations.These children showed a statistically signifcant diference between the 0-3 day group and the 4-7 day group(P=0.0392)and a signifcant diference between the 4-7 day group and the more than 8 days group(P=0.0003).Conclusions The early manifestations of COVID-19 in children with abnormal imaging are mostly small subpleural nodular ground glass opacity.The changes on the Delta-variant COVID-19 chest CT were milder than the original strain.The lesions reached a peak on CT in 4-7 days and quickly improved and absorbed after a week.Dynamic CT re-examination can achieve a good prognosis.

Analysis of clinical characteristics of 66 pediatric patients with B.1.617.2(Delta)variant of COVID-19

Background The aim of this study was to analyze the clinical characteristics of 66 pediatric patients with B.l.617.2(Delta)variant of coronavirus disease 2019(COVID-19).Methods Sixty-six pediatric patients with B.1.617.2(Delta)variant of COVID-19 admitted to the hospital from July to August 2021 were classified into mild(n=41)and moderate groups(n=25).Clinical characteristics,laboratory data and dynamic trends in different time periods were analyzed retrospectively.Results There were no statistically significant differences in age,gender ratios and clinical symptoms between the mild group and the moderate group.All the patients in the moderate group had clusters of onsets,and the incubation period was shorter than that of the mild group.Within 24 hours of admission,the levels of erythrocyte sedimentation rate,cardiac troponin I,D-dimer in the moderate group were higher than that in the mild group(P<0.05).The titers of immunoglobulin(Ig)G and IgM antibodies gradually increased after disease onset.Thirty-five(53.03%)children were tested positive for antibodies in 4-12 days.IgG increased gradually,while IgM decreased obviously in about 15 days after disease onset.The cycle threshold values of open reading frame lab and nucleocapsid protein gene in the severe acute respiratory syndrome coronavirus 2 genomes in creased gradually on the 3rd,6th,9th,and 12th days after disease onset,compared with those in day 0.Conclusions The symptoms of children with B.l.617.2(Delta)variant of COVID-19 were mild.The description and analysis of the clinical characteristics and laboratory data can help medical stafiF to evaluate the condition of children with COVID-19 and to accumulate more clinical experience.