Novel mutation in OCRL leading to a severe form of Lowe syndrome

AIM: To investigate the phenotype and genotype of a family with X-linked recessive Lowe syndrome. METHODS: All the members in the Chinese pedigree underwent comprehensive ophthalmologic and systemic examinations. Genomic DNA was isolated from peripheral blood of the pedigree members and 100 unrelated healthy Chinese subjects. Direct sequencing was performed to screen the exons and intron boundaries of OCRL.RESULTS: The ophthalmological and systemic exami nations suggested that the affected individual had Lowe syndrome. The phenotype in the pedigree is severe and consistent among all the affected individuals except for an individual who additionally suffered from congenital heart disease and laryngeal cartilage dysplasia. Directio nal San ger sequenci ng identified a complex mutation c.(2368_2368delG;c.2370A>C) in the Rho-GTPase activating protein domain. This complex mutation causes termination of protein synthesis at amino acid 824 and result in a new peptide with 823 amino acids (p.Ala790ProfsX34). This mutation was not detected in 100 unrelated healthy Chinese subjects.CONCLUSION: Our findings expand the phenotypic and genotypic spectrum of Lowe syndrome.

Tunable surface plasmon-polariton resonance in organic light-emitting devices based on corrugated alloy electrodes

We report a feasible method to realize tun able surface plasm on-polarit on(SPP)res onance in orga nic light-emitt ing devices(OLEDs)by emplo ying corrugated Ag-Al alloy electrodes.The excited SPP res onance in duced by the periodic corrugations can be precisely tuned based on the composition ratios of the Ag-Al alloy electrodes.With an appropriate composition ratio of the corrugated alloy electrode,the photons trapped in SPP modes are recovered and extracted effectively.The 25%in creaseme nt in luminance and 21%enhan ceme nt in curre nt efficie ncy have bee n achieved by using the corrugated Ag-Al alloy electrodes in OLEDs.

On-chip single-photon chirality encircling exceptional points

Exceptional points(EPs),which are typically defined as the degener-acy points of a non-Hermitian Hamiltonian,have been investigated in various physical systems such as photonic systems.In particular,the intriguing topological structures around EPs have given rise to novel strategies for manipulating photons and the underlying mechanism is especially useful for on-chip photonic applications.Although some on-chip experiments with the adoption of lasers have been reported,EP-based photonic chips working in the quantum regime largely re-main elusive.In the current work,a single-photon experiment was proposed to dynamically encircle an EP in on-chip photonic waveg-uides possessing passive anti-parity-time symmetry.Photon coinci-dences measurement reveals a chiral feature of transporting single photons,which can act as a building block for on-chip quantum de-vices that require asymmetric transmissions.The findings in the cur-rent work pave the way for on-chip experimental study on the physics of EPs as well as inspiring applications for on-chip non-Hermitian quantum devices.

Mechanically robust stretchable organic optoelectronic devices built using a simple and universal stencil-pattern transferring technology

Stretchable electronic and optoelectronic devices based on controllable ordered buckling structures exhibit superior mechanical stability by retaining their buckling profile without distortion in repeated stretch-release cycles.However,a simple and universal technology to introduce ordered buckling structures into stretchable devices remains a real challenge.Here,a simple and general stencil-pattern transferring technology was applied to stretchable organic lightemitting devices(SOLEDs)and polymer solar cells(SPSCs)to realize an ordered buckling profile.To the best of our knowledge,both the SOLEDs and SPSCs with periodic buckles exhibited the highest mechanical robustness by operating with small performance variations after 20,000 and 12,000 stretch-release cycles between 0%and 20%tensile strain,respectively.Notably,in this work,periodic-buckled structures were introduced into SPSCs for the first time,with the number of stretch-release cycles for the SPSCs improved by two orders of magnitude compared to that for previously reported random-buckled stretchable organic solar cells.The simple method used in this work provides a universal solution for low-cost and high-performance stretchable electronic and optoelectronic devices and promotes the commercial development of stretchable devices in wearable electronics.

Dynamically encircling an exceptional point in antiparity-time symmetric systems:asymmetric mode switching for symmetry-broken modes

Dynamically encircling an exceptional point(EP)in parity-time(PT)symmetric waveguide systems exhibits interesting chiral dynamics that can be applied to asymmetric mode switching for symmetric and anti-symmetric modes.The counterpart symmetry-broken modes(i.e.,each eigenmode is localized in one waveguide only),which are more useful for applications such as on-chip optical signal processing,exhibit only non-chiral dynamics and therefore cannot be used for asymmetric mode switching.Here,we solve this problem by resorting to anti-parity-time(anti-PT)symmetric systems and utilizing their unique topological structure,which is very different from that of PT-symmetric systems.We find that the dynamical encircling of an EP in anti-PT-symmetric systems with the starting point in the PT-broken phase results in chiral dynamics.As a result,symmetry-broken modes can be used for asymmetric mode switching,which is a phenomenon and application unique to anti-PT-symmetric systems.We perform experiments to demonstrate the new wave-manipulation scheme,which may pave the way towards designing on-chip optical systems with novel functionalities.