中国口咽癌的发病率、死亡率和时间格局:一项基于人群的研究

背景与目的目前,关于我国口咽癌(oropharyngeal cancer,OPC)的发病率、死亡率和时间格局的相关数据较少。我们根据135个国内居民肿瘤登记处的数据估算了中国2008–2012年OPC的发病率、死亡率和时间格局,更清楚地了解了中国OPC的流行病学特点,为OPC的预防和控制提供更精确的信息。方法根据2008–2012年135个肿瘤登记处的OPC诊断数据,我们按照年龄、性别和地区,以2000年中国标准人口为标准估算了中国年龄标准化发病率和死亡率(age-standardized rate of incidence by Chinese standard population,ASRIC和age-standardized rate of mortality by Chinese standard population,ASRMC),以1985年Segi's世界标准人口为标准估算了世界年龄标准化发病率和死亡率(age-standardized rate of incidence byworld standard population,ASRIW和age-standardized rate of mortality by world standard population,ASRMW)。采用Joinpoint软件计算OPC发病率和死亡率的年百分比变化。结果 ASRIW和ASRMW分别为2.22/100,000人–年和0.94/100,000人–年。城市地区的发病率和死亡率高于农村地区。男性的ASRIC和ASRIW高于女性。OPC的总ASRIC从2003年到2006年每年显著提高6.2%(P=0.038),但在2007年到2012年间保持稳定(P=0.392)。在近10年,男性和农村地区的ASRIC和ASRMC显著提高(P <0.05),但同一时期女性的相关比例数据仍保持稳定(P> 0.05)。结论近10年,在中国多个肿瘤登记处OPC的发病率和死亡率显著增加,尤其是男性和农村地区,但女性的相关比例数据仍保持稳定。应倡导健康的生活方式,并加强OPC早期诊断和早期治疗措施。

Oncogenic Wnt3a expression as an estimable prognostic marker for hepatocellular carcinoma

AIM: To investigate member 3a of Wingless-type MMTV integration site family(Wnt3a) expression in cancerous and surrounding tissues and the relationship between clinicopathologic features of hepatocellular carcinoma(HCC) and Wnt3 a expression.METHODS: Wnt3 a expression and cellular distribution and clinicopathologic characteristics in cancerous tissue and matched surrounding tissues were analyzed in 80 HCC patients from January 2006 to August 2008 by tissue microarrays and immunohistochemistry. The overall and disease-free survival rates were estimated using the Kaplan-Meier method and compared with the log-rank test. The prognostic analysis was carried out with univariate and multivariate Cox regressions models.RESULTS : The incidence of oncogenic Wnt3a expression in the cancerous group was up to 96.25%(77 of 80), which was significantly higher(χ2 = 48.818, P < 0.001) than that in the surrounding group(46.25%, 37 of 80). Brown Wnt3 a staining gradually increased with clinical staging that showed very strong staining in advanced HCC. The clinicopathologic features of high Wnt3 a expression in HCC were related to poorlydifferentiated grade(χ2 = 20.211, P < 0.001), liver cirrhosis(χ2 = 8.467, P < 0.004), hepatitis B virus(HBV) infection(χ2 = 12.957, P < 0.001), higher tumor-nodemetastasis stage(χ2 = 22.960, P < 0.001), and 5-year survival rate(χ2 = 15.469, P < 0.001).CONCLUSION: Oncogenic Wnt3 a expression associated with HBV infection and cirrhotic liver might be an independent prognostic factor for HCC.

Incidence, mortality, and temporal patterns of oropharyngeal cancer in China: a population-based study

Background:Thus far,the incidence,mortality,and temporal trend data of oropharyngeal cancers(OPC)in China were few.We estimated the incidence,mortality,and temporal patterns of OPC in China during 2008-2012 according to the data from 135 population-based cancer registries to better understand the epidemiological pattern of OPC and to provide more precise information for OPC control in China.Methods:According to the data of diagnosed OPC reported to 135 cancer registries during 2008-2012,we calcu-lated age-standardized rate of incidence and mortality by 2000 Chinese standard population(ASRIC and ASRMC)and by 1985 Segi’s world standard population(ASRIW and ASRMW)by age,sex,and geographic regions;annual percent-age changes of OPC incidence and mortality were calculated using Joinpoint trend analysis.Results:ASRIW and ASRMW were 2.22/100,000 person-years and 0.94/100,000 person-years,respectively.The incidence and mortality in urban areas were higher than those in rural areas.ASRIC and ASRIW of males were higher than those of females.The overall ASRIC of OPC was significantly increased by 6.2%annually between 2003 and 2006(P=0.038),but remained stable between 2007 and 2012(P=0.392).ASRIC and ASRMC of males and in rural areas were significantly increased in the last decade(P<0.05),but the rates of females remained stable during the same period(P>0.05).Conclusions:Across multiple cancer registries in China,there was an obvious increase in OPC in the recent decade,especially for incidence and mortality of males and in rural areas,whereas the rates of females remained stable.A healthy lifestyle should be advocated and early diagnosis and early treatment of OPC should be enhanced.

Correction to:Incidence,mortality,and temporal patterns of oropharyngeal cancer in China:a population-based study

In the original publication of this article[1],the num-ber of death cases in‘Materials and methods’section is incorrect.The original sentence is‘We quantified 20,618 new diagnoses of OPC and 9635 death cases that were reported to the 135 population-based cancer registries between 1 January 2008 and 31 December 2012 in China’.The correct number of death cases is 9335.