Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example

The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.

Releasing of Cupric Ion of Three types of Copper-bearing Intrauterine Contraceptive Device in Simulated UterineFluid

Objective To compare the cupric ion releasing in vitro o.f the three IUDs. Methods The stability o.f cupric ion releasing o.f IUDs including TCu 380.4 IUD （TCu 380A）, Multiload Cu375 IUD （MCu 375） and Yuangong 365 copper-bearing indomethacin-releasing IUD （Yuangong 365） by the determination of cupric ion releasing in simulated uterine fluid. The simulated uterine fluid was used for releasing media. Copper ion was determined by flame atomic absorption spectrometer. Results The cupric ion releasing of three IUDs were instable at the beginning and tend to be stable gradually. In the stable phase, the average level of cupric ion releasing of TCu380A, MCu375 and Yuangong 365 were 4.25±2.71-7.62±6.42 μg, 4.92±1.23 -8.62±3.08 μg and 2.19±0.40-4.68±1.66 μg, respectively. TCu380A had higher instable releasing level than those of Yuangong 365 （P〈0. 05）. Conclusion TCu 380.4 and MCu 375 showed a ＂burst release＂ during the first few days and the.former was of great significance（P〈0.05）. The initial cupric ion releasing of Yuangong 365 appeared to be the lowest, followed by MCu375 and TCu380A in a releasing order

Three decades of topic evolution,hot spot mining and prospect in CCUS Studies based on CitNetExplorer

As a major strategic technology for reducing greenhouse gas emissions and ensuring energy security,carbon capture,utilization,and storage(CCUS)is of great significance to large-scale emission reduction.From the perspective of knowledge discovery,it is important to analyse the study progress based on existing study achievements,excavate the evolution characteristics of study topics over time,review stage-specific findings,and construct CCUS domain knowledge map.This will help researchers gain an overall understanding of CCUS studies and promote the industry-college-research cooperation in respect to CCUS.Based on the Web of Science(WOS)database platform and CitNet-Explorer software,the present study explore the international research progress,topic evolution track,research hotspot and research trend of CCUS technology since its birth nearly 30 years ago,using bibliometric method,citation network visualization analysis method and cluster analysis method.Through the analysis of literature citation network,it is found that:16 CCUS topics,6 hotspots have been studied in the last three decades.The topics of CCUS studies present an evolution path from CCUS technology security and economicfeasibility analysis to CCUS technological popularization,and then CCUS technological improvement and development.Cutting-edge CCUS looks at the process and infrastructure construction,cost effectiveness and development prospect analysis.CCUS focuses on improvement of process technologies and related infrastructure.

An empirical study on the green effects of new energy vehicle promotion in the context of global carbon neutrality

In the context of global carbon neutrality,new energy vehicle promotion(NEVP)has become an important means of reducing carbon emissions.This paper constructs a theoretical model and uses panel data on NEVP in 21 countries from 2012 to 2018 to empirically examine the green effect of NEVP.The results indicate the following:(1)NEVP significantly reduces greenhouse gases emissions,and the green effect can be transmitted and diffused through a direct path.(2)Replacing fuel-fired vehicles and accelerating the end-of-life vehicle scrapping process significantly conducted the green effect,and aggravating traffic congestion was not statistically significant.(3)The transmission mechanism of the green effect is regulated by regional economic heterogeneity.In regions with better development of fuel-fired vehicles,the transmission of the green effect is subject to the elimination of fuel-fired vehicles and traffic congestion governance,and the transmission efficiency is low.However,regions with a relatively weak fuel-fired automobile industry foundation show a strong“advantage of backwardness”,and the green effect is more prominent.This means that global NEVP should be further accelerated to achieve the green effect and the goal of global carbon neutrality.

Effects of Tocols Rich Fraction Isolated from Rice Bran Oil Deodorizer Distillate on Plasma and Hepatic Lipid Concentrations in Rats

A great deal of attention has been focused on the potential health benefits of using rice bran oil because it is a rich source of bioactive compounds. Rice bran oil deodorizer distillate (RBODD) is a byproduct obtained from distillation of rice bran oil. Elevated plasma cholesterol level is one of the major risk factors for coronary heart disease. The objective of this study was to investigate the effects of tocols (tocopherols + tocotrienols) rich fraction isolated from RBODD on plasma and liver lipid concentrations in rats. Male Sprague Dawley rats (6 weeks of age) were randomly assigned into three groups: normal fat control (NFC), high fat control (HFC) and high fat diet plus tocols rich fraction (RBODD). RBODD was administered daily for 3 weeks by oral gavage using 5% of Tween-80 as a vehicle. The rats in the control groups received 5% of Tween-80 alone in the same manner. Blood samples and livers were collected at the end of the feeding period. RBODD group had significantly lower plasma triglyceride levels compared to the HFC group (p < 0.05). However, no significant changes for plasma total and lipoprotein cholesterol levels were found in RBODD compared with HFC. Compared to the rat fed HFC, hepatic free fatty acids were significantly reduced in the rats with the RBODD treatment (p < 0.05). The results suggest that the tocols rich fraction isolated from RBODD is associated with decreased plasma triglyceride and hepatic free fatty acids concentrations. Further study is needed to investigate the mechanism and optimal dose by which isomers of tocols lower triglyceride concentrations.