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Bone morphogenetic protein-6 suppresses TGF-β_(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium
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作者 xuan liu Ming liu +5 位作者 Meng Ji Bo Ma Yu-Cen Hou Xin-Yue Yao Qiao-Chu Cheng Li Chen 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第4期646-652,共7页
AIM:To evaluate the effect of bone morphogenetic protein-6(BMP-6)on transforming growth factor(TGF)-β_(2)-induced epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE).METHODS:Adult retinal pigment... AIM:To evaluate the effect of bone morphogenetic protein-6(BMP-6)on transforming growth factor(TGF)-β_(2)-induced epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE).METHODS:Adult retinal pigment epithelial cell line(ARPE-19)were randomly divided into control,TGF-β_(2)(5μg/L),and BMP-6 small interfering RNA(siRNA)group.The cell morphology was observed by microscopy,and the cell migration ability were detected by Transwell chamber.The EMT-related indexes and BMP-6 protein levels were detected by Western blotting.Furthermore,a BMP-6 overexpression plasmid was constructed and RPE cells were divided into the control group,TGF-β_(2)+empty plasmid group,BMP-6 overexpression group,and TGF-β_(2)+BMP-6 overexpression group.The EMT-related indexes and extracellular regulated protein kinases(ERK)protein levels were detected.RESULTS:Compared with the control group,the migration of RPE cells in the TGF-β_(2) group was significantly enhanced.TGF-β_(2) increased the protein expression levels ofα-smooth muscle actin(α-SMA),fibronectin and vimentin but significantly decreased the protein levels of E-cadherin and BMP-6(P<0.05)in RPE.Similarly,the migration of RPE cells in the BMP-6 siRNA group was also significantly enhanced.BMP-6 siRNA increased the protein expression levels ofα-SMA,fibronectin and vimentin but significantly decreased the protein expression levels of E-cadherin(P<0.05).Overexpression of BMP-6 inhibited the migration of RPE cells induced by TGF-β_(2) and prevented TGF-β_(2) from affecting EMT-related biomarkers(P<0.05).CONCLUSION:BMP-6 prevents the EMT in RPE cells induced by TGF-β_(2),which may provide a theoretical basis for the prevention and treatment of proliferative vitreoretinopathy. 展开更多
关键词 bone morphogenetic protein-6 epithelialmesenchymal transition transforming growth factor-β_(2) retinal pigment epithelial cells cell migration
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Apoptosis of colon cancer CT-26 cells induced polysaccharide from Cyclocarya paliurus and its phosphorylated derivative via intrinsic mitochondrial passway 被引量:1
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作者 liuming Xie Mingyue Shen +4 位作者 Rong Huang xuan liu Yue Yu Hanyu Lu Jianhua Xie 《Food Science and Human Wellness》 SCIE CSCD 2023年第5期1545-1556,共12页
In this study,the antitumor properties and the possible molecular mechanisms of Cyclocarya paliurus polysaccharide(CP)and its phosphorylated derivative(P-CP)on CT-26 mouse colon carcinoma cells were investigated.Resul... In this study,the antitumor properties and the possible molecular mechanisms of Cyclocarya paliurus polysaccharide(CP)and its phosphorylated derivative(P-CP)on CT-26 mouse colon carcinoma cells were investigated.Results found that CP had high inhibition ratio against CT-26 cells.The flow cytometry results found that CP treatment could cause the intracellular acidification,arrest the cell cycle in the S phase and increase reactive oxygen species generation.Additionally,CP treatment triggered mitochondrial membrane potential depolarization and Ca^(2+)overloading,and broke down the balance of antioxidant system,Na^(+)/K^(+)-ATPase and Ca^(2+)-ATPase.Further analysis found CP induced cell apoptosis through improving the activities of caspase-3 and caspase-9,and increasing the level of cytochrome C.Furthermore,the comparative study of antitumor effect on CT-26 cells displayed that the phosphorylation enhanced antitumor activities of polysaccharides.These results suggest CP is a potential natural therapeutic agent for colon cancer and phosphorylation represents an effective method of enhancing the antitumor activity of CP. 展开更多
关键词 Cyclocarya paliurus polysaccharide Phosphorylated Colorectal cancer Mitochondrial apoptosis pathway
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外源性硫化氢抑制动脉粥样硬化形成机理探讨
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作者 宣柳 刘增辉 +1 位作者 马筝 王超 《中国临床保健杂志》 CAS 2024年第3期378-381,共4页
目的探讨硫氢化钠(NaHS,硫化氢供体)对兔动脉粥样硬化的调节作用。方法40只新西兰兔分为正常组、模型组、NaHS组、炔丙基甘氨酸组(PPG,胱硫醚-γ-裂解酶合成酶抑制剂),每组各10只。正常组为普通饲料饲养,其他各组均以高脂饲养(2%胆固醇+... 目的探讨硫氢化钠(NaHS,硫化氢供体)对兔动脉粥样硬化的调节作用。方法40只新西兰兔分为正常组、模型组、NaHS组、炔丙基甘氨酸组(PPG,胱硫醚-γ-裂解酶合成酶抑制剂),每组各10只。正常组为普通饲料饲养,其他各组均以高脂饲养(2%胆固醇+10%猪油)。12周后检测血脂含量包括三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C);亚甲蓝法测定血清中硫化氢(H_(2)S)的含量;比色法检测氧化还原指标超氧化物歧化酶(SOD)活性,丙二醛(MDA)含量;HE染色观察主动脉根部组织病理学变化。结果相对于模型组,NaHS组兔血清中血脂变化差异无统计学意义;血清中H_(2)S的含量和SOD活性明显上升,MDA含量明显下降;HE染色显示内膜/中层厚度比值,I+M、内膜/中层面积的比值明显下降(P<0.05)。相对于NaHS组,PPG组中H_(2)S含量和SOD活性明显下降,MDA含量明显上升;HE染色显示内膜/中层厚度比值、I+M、内膜/中层面积的比值明显升高(P<0.05)。结论应用外源性硫化氢可通过改变机体氧化应激状态,抑制动脉粥样硬化的形成。 展开更多
关键词 动脉粥样硬化 硫化氢 氧化性应激 模型 动物
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Recent progress of self-supported air electrodes for flexible Zn-air batteries 被引量:1
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作者 Chen Xu Yanli Niu +5 位作者 Vonika Ka-Man Au Shuaiqi Gong xuan liu Jianying Wang Deli Wu Zuofeng Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第2期110-136,I0004,共28页
Smart wearable devices are regarded to be the next prevailing technology product after smartphones and smart homes,and thus there has recently been rapid development in flexible electronic energy storage devices.Among... Smart wearable devices are regarded to be the next prevailing technology product after smartphones and smart homes,and thus there has recently been rapid development in flexible electronic energy storage devices.Among them,flexible solid-state zinc-air batteries have received widespread attention because of their high energy density,good safety,and stability.Efficient bifunctional oxygen electrocatalysts are the primary consideration in the development of flexible solid-state zinc-air batteries,and self-supported air cathodes are strong candidates because of their advantages including simplified fabrication process,reduced interfacial resistance,accelerated electron transfer,and good flexibility.This review outlines the research progress in the design and construction of nanoarray bifunctional oxygen electrocatalysts.Starting from the configuration and basic principles of zinc-air batteries and the strategies for the design of bifunctional oxygen electrocatalysts,a detailed discussion of self-supported air cathodes on carbon and metal substrates and their uses in flexible zinc-air batteries will follow.Finally,the challenges and opportunities in the development of flexible zinc-air batteries will be discussed. 展开更多
关键词 Bifunctional electrocatalysts Oxygen reduction reaction Oxygen evolution reaction Self-supported air electrodes Flexible zinc-air batteries
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通过钨对镍活性位点的电子改性实现苯甲胺选择性氧化耦合制氢
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作者 屠振涛 何晓洋 +5 位作者 刘璇 熊登科 左娟 吴德礼 汪建营 陈作锋 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第3期146-156,共11页
苯甲腈(BN)作为精细化学品、农用化学品和药品生产的重要中间体,其制备受到研究人员的广泛关注.传统的BN化学合成涉及有机物与氰化物之间的亲核取代反应.然而,由于氰化物等剧毒化学试剂的使用,这一反应在实际应用中受到了一定的限制.最... 苯甲腈(BN)作为精细化学品、农用化学品和药品生产的重要中间体,其制备受到研究人员的广泛关注.传统的BN化学合成涉及有机物与氰化物之间的亲核取代反应.然而,由于氰化物等剧毒化学试剂的使用,这一反应在实际应用中受到了一定的限制.最近研究发现,苯甲胺(BA)电化学氧化可为BN的生产提供一种清洁、高效、高选择性的方法.此外,与析氧反应(OER)相比,苯甲胺氧化反应(BAOR)具有明显的热力学优势;将BAOR与阴极析氢反应(HER)耦合,可提高整体电解体系的能效和经济效益.因此,开发高效双功能电催化剂用于苯甲胺氧化及耦合析氢反应具有重要的基础研究意义和实际应用价值.本文通过直接水热和高温磷化的方法,在泡沫镍基底上负载了一种W-Ni_(2)P纳米片(W-Ni_(2)P/NF),并探索了其作为双功能电催化剂在BAOR和HER的应用.实验结果显示,催化剂的纳米片结构不仅提供了充足的活性位点,还有助于离子传输.钨的掺杂显著增强了电化学传导性,改善了水吸附性,并优化了氢吸附能,进而提升了催化剂的HER性能.此外,钨的引入促进了电子从镍向钨的转移,形成了缺电子的镍区域;在W-Ni_(2)P催化的BAOR过程中,缺电子的镍活性位点与供电子的氨基(-NH2)相互作用,有效促进了氨基的吸附和活化,进一步推动了脱氢反应和C≡N键的形成.电化学测试结果表明,在1 mol L^(‒1)KOH溶液中,W-Ni_(2)P催化剂发生HER的过电位为80 mV(10 mA cm^(-2)),其性能可与商业Pt/C电极相媲美.在含有25 mmol L^(‒1)BA的1 mol L^(‒1)KOH溶液中,仅需施加1.42 V电位,W-Ni_(2)P催化剂即可达到100 mA cm^(-2)的氧化电流密度,这比OER所需电位低350 mV.此外,当组装W-Ni_(2)P/NF||W-Ni_(2)P/NF电解槽时,在1 mol L^(‒1)KOH和25 mmol L^(‒1)BA的电解液中,仅需1.41 V的电解电压即可达到10 mA cm^(-2)的电流密度,实现了阴极制氢和阳极增值BN的同时生产,且反应的法拉第效率达到95%.采用电化学原位拉曼光谱和红外光谱研究了反应的活性位点和关键中间产物.结合密度泛函理论计算,阐明了BAOR的催化机理以及反应路径,深入分析了W掺杂在优化吸附能和提高W-Ni2P电催化剂催化活性方面的优化作用.综上所述,本文成功制备了高活性、高稳定性的钨掺杂磷化镍纳米片双功能催化剂,并将其应用于两电极电解体系中,实现了阴、阳极高附加值产物(苯甲腈和氢气)的同时生成.本研究为电化学合成高价值腈化合物和制氢先进催化剂的设计、制备提供了一定的参考和借鉴. 展开更多
关键词 双功能电催化剂 选择性氧化 苯甲腈电合成 脱氢作用 析氢反应
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A STAMP-Game model for accident analysis in oil and gas industry
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作者 Huixing Meng Xu An +4 位作者 Daiwei Li Shijun Zhao Enrico Zio xuan liu Jinduo Xing 《Petroleum Science》 SCIE EI CAS CSCD 2024年第3期2154-2167,共14页
Accidents in engineered systems are usually generated by complex socio-technical factors.It is beneficial to investigate the increasing complexity and coupling of these factors from the perspective of system safety.Ba... Accidents in engineered systems are usually generated by complex socio-technical factors.It is beneficial to investigate the increasing complexity and coupling of these factors from the perspective of system safety.Based on system and control theories,System-Theoretic Accident Model and Processes(STAMP)is a widely recognized approach for accident analysis.In this paper,we propose a STAMP-Game model to analyze accidents in oil and gas storage and transportation systems.Stakeholders in accident analysis by STAMP can be regarded as players of a game.Game theory can,thus,be adopted in accident analysis to depict the competition and cooperation between stakeholders.Subsequently,we established a game model to study the strategies of both supervisory and supervised entities.The obtained results demonstrate that the proposed game model allows for identifying the effectiveness deficiency of the supervisory entity,and the safety and protection altitudes of the supervised entity.The STAMP-Game model can generate quantitative parameters for supporting the behavior and strategy selections of the supervisory and supervised entities.The quantitative data obtained can be used to guide the safety improvement,to reduce the costs of safety regulation violation and accident risk. 展开更多
关键词 Accident analysis STAMP System engineering Gametheory Oil and gas storage and transportation SYSTEMS
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Reconcile the contradictory wettability requirements for the reduction and oxidation half-reactions in overall CO_(2) photoreduction via alternately hydrophobic surfaces
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作者 Hailing Huo Ting Hu +9 位作者 Chengxi Huang Fang Wu Tongyu Wang xuan liu Liang Zhang Qiang Ju Zhiqing Zhong Hongbin Xing Erjun Kan Ang Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期202-212,I0006,共12页
The overall photocatalytic CO_(2) reduction reaction(OPCRR)that can directly convert CO_(2) and H_(2)O into fuels represents a promising renewable energy conversion technology.As a typical redox reaction,the OPCRR inv... The overall photocatalytic CO_(2) reduction reaction(OPCRR)that can directly convert CO_(2) and H_(2)O into fuels represents a promising renewable energy conversion technology.As a typical redox reaction,the OPCRR involves two half-reactions:the CO_(2) reduction half-reaction(CRHR)and the water oxidation half-reaction(WOHR).Generally,both half-reactions can be promoted by adjusting the wettability of catalysts.However,there is a contradiction in wettability requirements for the two half-reactions.Specifically,CRHR prefers a hydrophobic surface that can accumulate more CO_(2) molecules on the active sites,ensuring the appropriate ratio of gas-phase(CO_(2))to liquid-phase(H_(2)O)reactants.Conversely,the WOHR prefers a hydrophilic surface that can promote the departure of the gaseous product(O_(2))from the catalyst surface,preventing isolation between active sites and the reactant(H_(2)O).Here,we successfully reconciled the contradictory wettability requirements for the CRHR and WOHR by creating an alternately hydrophobic catalyst.This was achieved through a selectively hydrophobic modification method and a charge-transfer-control strategy.Consequently,the collaboratively promoted CRHR and WOHR led to a significantly enhanced OPCRR with a solar-to-fuel conversion efficiency of 0.186%.Notably,in ethanol production,the catalyst exhibited a 10.64-fold increase in generation rate(271.44μmol g^(-1)h~(-1))and a 4-fold increase in selectivity(55.77%)compared to the benchmark catalyst.This innovative approach holds great potential for application in universal overall reactions involving gas participation. 展开更多
关键词 HYDROPHOBIC HYDROPHILIC Gas transport Overall CO_(2)photoreduction Z-scheme
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The in vitro digestion fates of diacylglycerol under different intestinal conditions:a potential lipid source for lipid indigestion patients
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作者 Qingqing Xu Weifei Wang +5 位作者 Dongxiao Sun-Waterhouse Qian Zou Menglei Yan xuan liu Dongming Lan Yonghua Wang 《Food Science and Human Wellness》 SCIE CSCD 2024年第2期1079-1092,共14页
The in vitro digestion models mimicking the gastrointestinal(GI)tract of general population and lipid indigestion patients(with lower levels of bile salts or pancreatic lipase)were selected to investigate whether diac... The in vitro digestion models mimicking the gastrointestinal(GI)tract of general population and lipid indigestion patients(with lower levels of bile salts or pancreatic lipase)were selected to investigate whether diacylglycerols(DAGs)are potential good lipid sources for these patients.Linseed oil-based DAG(LD)and linseed oil(LT)were selected.LD-based emulsion((83.74±1.23)%)had higher lipolysis degree than LT-based emulsion((74.47±1.16)%)when monitoring the GI tract of normal population as previously reported.Indigestion conditions seriously decreased the digestive degree of LT-based emulsion((40.23±2.48)%-(66.50±3.70)%)while showed less influence on LD-based emulsion((64.18±2.41)%-(81.85±3.45)%).As opposed to LT-based emulsion,LD-based emulsion exhibited preference for releasing unsaturated fatty acids(especially oleic acid andα-linolenic acid)due to their different glycerolipid compositions.LD-based emulsion showed potential for providing lipids and nutrients(including essential fatty acids)for lipid indigestion patients. 展开更多
关键词 DIACYLGLYCEROL In vitro digestion Lipolysis level Cholestatic Exocrine pancreatic insufficiency
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MAPK9 as a therapeutic target:unveiling ferroptosis in localized prostate cancer progression
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作者 CHENG-GONG LUO JIAO ZHANG +10 位作者 YUN-ZHAO AN xuan liu SHUAI-JIE LI WEI ZHANG KAI LI XU ZHAO DONG-BO YUAN LING-YUE AN WEI CHEN YE TIAN BIN XU 《BIOCELL》 SCIE 2024年第5期771-792,共22页
Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehens... Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehensive investigation is essential for understanding its impact on patient prognosis.Methods:A risk model incorporating four ferroptosis-related genes was developed and validated.Elevated risk scores correlated with an increased likelihood of biochemical recurrence(BCR),diminished immune infiltration,and adverse clinicopathological characteristics.To corroborate these results,we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort(TCGA)and the Gene Expression Synthesis Cohort(GEO).Moreover,we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays,as well as animal studies conducted in vivo.Additionally,we conducted further experiments involving ferroptosis-related analysis to validate its association with ferroptosis.Results:The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa patients.Mitogen-activated protein kinase 9(MAPK9)emerged as a crucial gene within the model.In vivo and in vitro experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and proliferation.Conclusion:The findings provide a novel perspective for advancing ferroptosis exploration in PCa,bridging basic research and clinical applications. 展开更多
关键词 Ferroptosis Biochemical recurrence Prostate cancer TCGA GEO MAPK9
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High-quality ghost imaging based on undersampled natural-order Hadamard source
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作者 Kang liu Cheng Zhou +4 位作者 Jipeng Huang Hongwu Qin xuan liu Xinwei Li Lijun Song 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第9期404-411,共8页
Improving the speed of ghost imaging is one of the main ways to leverage its advantages in sensitivity and imperfect spectral regions for practical applications.Because of the proportional relationship between image r... Improving the speed of ghost imaging is one of the main ways to leverage its advantages in sensitivity and imperfect spectral regions for practical applications.Because of the proportional relationship between image resolution and measurement time,when the image pixels are large,the measurement time increases,making it difficult to achieve real-time imaging.Therefore,a high-quality ghost imaging method based on undersampled natural-order Hadamard is proposed.This method uses the characteristics of the Hadamard matrix under undersampling conditions where image information can be fully obtained but overlaps,as well as deep learning to extract aliasing information from the overlapping results to obtain the true original image information.We conducted numerical simulations and experimental tests on binary and grayscale objects under undersampling conditions to demonstrate the effectiveness and scalability of this method.This method can significantly reduce the number of measurements required to obtain high-quality image information and advance application promotion. 展开更多
关键词 ghost imaging natural-order Hadamard deep learning
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Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery
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作者 Jun-Ling Li Jin Zhao +2 位作者 Zhen-Feng Guo Chang Xiao xuan liu 《World Journal of Diabetes》 SCIE 2024年第6期1234-1241,共8页
BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical sign... BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical significance.AIM To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(SH)eye drops on DES after cataract surgery in patients with diabetes.METHODS We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April 2023.They were classified into an observation group(42 cases,rhEGF+SH eye drops)and a control group(40 cases,SH eye drops alone),depending on the different treatment schemes.The therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two groups.RESULTS Therapeutic efficacy was higher in the observation group compared with the control group.Both groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation group.Although no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation group.CONCLUSION rhEGF+SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety levels.Thus,this treatment should be promoted in clinical practice. 展开更多
关键词 Recombinant human epidermal growth factor Sodium hyaluronate eye drops Diabetic patients Dry eye syndrome after cataract surgery Therapeutic efficacy
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桂附汤对慢性不可预见性温和应激小鼠抑郁样行为及海马脑源性神经营养因子表达的影响 被引量:1
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作者 王超 李舜 +3 位作者 戴陈伟 马征 宣柳 罗胜勇 《食品安全质量检测学报》 CAS 北大核心 2023年第3期50-57,共8页
目的研究桂附汤对慢性不可预见性温和应激(chronic unpredictive mild stress,CUMS)小鼠抑郁样行为的干预作用及对脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)表达的影响。方法利用CUMS法诱导C57BL/6小鼠构建抑郁模型... 目的研究桂附汤对慢性不可预见性温和应激(chronic unpredictive mild stress,CUMS)小鼠抑郁样行为的干预作用及对脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)表达的影响。方法利用CUMS法诱导C57BL/6小鼠构建抑郁模型,通过蔗糖偏好实验、旷场实验、悬尾实验观察桂附汤对小鼠抑郁样行为的影响,采用实时荧光定量-聚合酶链式反应(real-time fluorescence quantitative-polymerase chain reaction,RTFQ-PCR)检测小鼠海马组织BDNF mRNA表达,免疫组化法(immunohistochemistry,IHC)检测小鼠海马区BDNF蛋白定位表达,苏木素-伊红(hematoxylin and eosin,HE)染色观察海马组织形态学的变化。结果与对照组相比,模型组体质量下降(P<0.01),肾上腺指数升高(P<0.05),糖水偏好度显著降低(P<0.01),旷场实验总静止时间显著升高(P<0.01)、进入中央区域次数显著降低(P<0.01),悬尾实验静止时间显著升高(P<0.01),BDNF蛋白表达和m RNA水平显著降低(P<0.01);与模型组相比,桂附汤高剂量组(P<0.01)、中剂量组和氟西汀组(P<0.05)肾上腺指数显著降低,桂附汤中、高剂量组和氟西汀组旷场实验总静止时间显著降低(P<0.01)、进入中央区域的次数显著增加(P<0.01),各干预组小鼠糖水偏好度显著增加(P<0.05),旷场实验总静止时间显著降低(P<0.01)、进入中央区域的次数显著增加(P<0.01),悬尾实验静止时间显著降低(P<0.01),海马BDNF m RNA及蛋白表达都显著增加(P<0.01),海马组织病理损伤明显改善。结论桂附汤可改善CUMS诱导的小鼠抑郁样行为,上调BDNF表达,保护海马神经元的结构和功能。 展开更多
关键词 桂附汤 慢性不可预见性温和应激 海马 脑源性神经营养因子 抑郁样行为
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641份具有磺酰胺结构的非抗菌药物说明书中交叉过敏警示标志分析及处方审核建议 被引量:2
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作者 刘璇 袁龙 +1 位作者 李为 刘宇 《药物流行病学杂志》 CAS 2023年第1期25-29,共5页
目的搜集临床常用具有磺酰胺结构非抗菌药物的药品说明书,分析该类药物说明书中交叉过敏事项的标记情况,探索处方审核策略。方法于2021年12月通过查询药智网说明书数据库、用药助手软件(手机版)以及MCDEX软件(网络版)收集国内常用具有... 目的搜集临床常用具有磺酰胺结构非抗菌药物的药品说明书,分析该类药物说明书中交叉过敏事项的标记情况,探索处方审核策略。方法于2021年12月通过查询药智网说明书数据库、用药助手软件(手机版)以及MCDEX软件(网络版)收集国内常用具有磺酰胺结构非抗菌药物的药品说明书,对说明书中涉及交叉过敏的警示语以及禁忌等内容进行分类汇总分析。结果符合入排标准的药物共分5大类17种药品。共收集641份具有磺酰胺结构非抗菌药物的说明书,包括循环利尿药115份,噻嗪类及相关利尿药189份,磺酰脲类降糖药273份,碳酸酐酶抑制药6份。其中有8种药品的说明书对交叉过敏事项标注存在分歧。结论目前国内具有磺胺结构非抗菌药物的说明书对交叉过敏事项的标注存在分歧,反映出该类药物的交叉过敏在实际应用中还有争议。在制定审方策略时应管控好说明书中的分歧,根据对应说明书的描述实现对此类药品交叉过敏的精准识别与提醒。 展开更多
关键词 磺酰胺结构 非抗菌药物 交叉过敏 药品说明书 药品风险管理
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燃料电池金属间Pt-M合金氧还原催化剂的设计原理及合成方法 被引量:2
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作者 刘轩 梁嘉顺 李箐 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2023年第2期17-26,共10页
开发用于氧还原反应(ORR)的高性能Pt-M(M=过渡金属)金属间合金催化剂是实现质子交换膜燃料电池(PEMFC)大规模应用的关键.因此迫切需要明确设计和制备具有高ORR活性和稳定性的金属间Pt-M催化剂的一般规则.本文首先概述了无序-有序相变的... 开发用于氧还原反应(ORR)的高性能Pt-M(M=过渡金属)金属间合金催化剂是实现质子交换膜燃料电池(PEMFC)大规模应用的关键.因此迫切需要明确设计和制备具有高ORR活性和稳定性的金属间Pt-M催化剂的一般规则.本文首先概述了无序-有序相变的热力学和动力学基本原理,然后介绍了本课题组在合成L10有序结构的Pt-M金属间纳米晶(iNC)方面的研究结果,进一步阐述了提高L10-Pt-M燃料电池ORR催化剂的活性和稳定性的有效策略.关于铂基金属间纳米晶的合成,本课题组基于高温相变扩散动力学发展了空位介导原子扩散的方法用于合成全有序铂基金属间纳米晶.铂基金属间纳米晶通常是通过高温退火制得,但该过程中原子的快速扩散会加剧奥斯特瓦尔德熟化和材料烧结,进而导致催化剂活性下降.对纳米晶进行包覆或者限域虽然能够在一定程度上降低高温退火过程中的颗粒团聚,但是原子扩散受限也导致难以获得完全有序的纳米晶.空位扩散是金属纳米晶有序转变过程中的主要扩散过程,可以在退火前驱体中构建Pt/MO_(x)界面.本课题组发展了空位介导原子扩散促进铂基合金有序化的方法,制得了一系列用于ORR反应的超细Pt-M(M=Fe,Co,Ni,Zn等)金属间纳米晶催化剂,实现了铂基金属间纳米晶的高效制备.关于铂基金属间纳米晶催化剂的活性调控,本课题组基于应变效应的调控策略开发了多种具有高氧还原活性的铂基金属间纳米晶催化剂.根据理论预测的铂表面最佳氧物种吸附能,通过掺杂钨原子调控表面应变,有效削弱了L1_(0)-PtCo纳米晶表面的过度应变,制得的催化剂表现出良好的催化活性.此外,介绍了双轴应变介导的高活性L1_(0)-PtZn/Pt-C催化剂,独特的表面应变模式使其在氧还原反应中表现出较好的催化活性,并在燃料电池器件中表现出较好的质量活性与功率密度.关于铂基金属间纳米晶催化剂稳定性的提升,本课题组基于腐蚀热力学与热力学原理发展了多种提升金属间纳米晶催化剂稳定性的方法.铂基金属间纳米晶组元间独特的强轨道相互作用在提升催化稳定性方面表现出明显优势,基于此,开发了具有强Pt(5d)-Ni/Co(3d)相互作用的C-L1_(0)-PtNi_(0.8)Co_(0.2)催化剂,其在加速稳定性测试后表现出良好的稳定性.此外,根据稳定表面的纳米表面工程方法,制备了低表面能的L10-W-Pt Co纳米晶,该催化剂在燃料电池测试中表现出较好的稳定性.针对催化剂的溶解腐蚀,本课题组开发了具有高表面空位形成能的L1_(0)-PtZn/Pt-C催化剂,有效降低了催化剂在燃料电池中的性能衰减,并且通过理论计算,揭示了金属间相结构热力学参数(形成能)与腐蚀过程动力学参数(空位形成能)的相关关系,有望为后续开发高稳定性铂基氧还原催化剂提供理论参考.综上,本文为未来应用于PEMFC和其他电化学能量转换技术的Pt-M金属间合金ORR催化剂的研究和开发提供一些借鉴. 展开更多
关键词 燃料电池 氧还原反应 铂基合金 金属间化合物 L10有序结构
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Interface Engineering and Anion Engineering of Mo-Based Heterogeneous Electrocatalysts for Hydrogen Evolution Reaction 被引量:1
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作者 Zehao Yin xuan liu +2 位作者 Siru Chen Tingli Ma Yanqiang Li 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2023年第1期87-104,共18页
Development and utilization of hydrogen energy is an effective way to achieve carbon neutrality,only hydrogen production through electrolytic water splitting meets the goal of zero carbon emission.To facilitate the la... Development and utilization of hydrogen energy is an effective way to achieve carbon neutrality,only hydrogen production through electrolytic water splitting meets the goal of zero carbon emission.To facilitate the large-scale commercialization of water splitting devices,the development of highly efficient and low-cost catalysts to reduce the energy consumption is essential.MoS_(2)has been regarded as a promising electrocatalyst to replace platinum in hydrogen evolution reaction due to its low price and unique 2D layered structure.However,the poor conductivity and inert basal planes of MoS_(2)limited its wide-spread application.Recently,researches have demonstrated that the conductivity and active sites of MoS_(2)can be improved by heteroatoms doping or constructing of heterogeneous structures.In this review,the recent progress of Mo-based catalysts are summarized centered on MoS_(2)based on interface engineering and anion engineering,including MoS_(2)–MoO_(2),MoS_(2)–Mo_(2)C,MoS_(2)–MoN_(x),MoS_(2)–MoP,and MoS_(2)–MoSe_(2).The preparation method,structure,and performance of the catalysts are introduced and the possible mechanism behind the improved catalytic activity are revealed to give readers an overall comprehension on the progress of the Mo-based electrocatalysts for hydrogen evolution reaction.In addition,an outlook on future opportunities and development directions of Mo-based catalysts are proposed to facilitate the development of Mo-based catalysts for hydrogen production. 展开更多
关键词 electrocatalysis heterostructure hydrogen evolution reaction Mo-based catalysts
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Factors influencing the surveillance of re-emerging intracranial infections in elective neurosurgical patients:A single-center retrospective study 被引量:1
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作者 Jiang-Long Wang Xi-Wen Wu +4 位作者 Sheng-Nan Wang xuan liu Bing Xiao Yu Wang Jing Yu 《World Journal of Clinical Cases》 SCIE 2023年第28期6680-6687,共8页
BACKGROUND At present,many studies have reported the risk factors for postoperative intracranial reinfection,including age,sex,time to surgery,duration of postoperative catheterization,emergency procedures,type of dis... BACKGROUND At present,many studies have reported the risk factors for postoperative intracranial reinfection,including age,sex,time to surgery,duration of postoperative catheterization,emergency procedures,type of disease and cerebrospinal fluid leakage,but the academic community has not reached a unified conclusion.AIM To find factors influencing the surveillance of re-emerging intracranial infections in elective neurosurgical patients.METHODS Ninety-four patients who underwent elective craniotomy from January 1,2015 to December 31,2022 in the Department of Neurosurgery,First Hospital of Jilin University,were included in this study.Of those,45 patients were enrolled in the infection group,and 49 were enrolled in the control group.The clinical data of the patients were collected and divided into three categories,including preoperative baseline conditions,intraoperative characteristics and postoperative infection prevention.The data were analyzed using SPSS 26.0 software.RESULTS There were 23 males and 22 females in the infection group with a mean age of 52.8±15.1 years and 17 males and 32 females in the control group with a mean age of 48.9±15.2 years.The univariate analysis showed that the infection group had higher systolic blood pressures and postoperative temperatures,fewer patients who underwent a supratentorial craniotomy,more patients with a history of hypertension and higher initial postoperative white blood cell counts than the control group,with statistically significant differences(P<0.05).The multifactorial logistic regression analysis showed that a history of hypertension and a high postoperative body temperature were independent risk factors for postoperative infection in neurosurgical patients.CONCLUSION The results obtained in this study indicated that a history of hypertension and a high postoperative body temperature were independent risk factors for postoperative neurological symptoms. 展开更多
关键词 Re-emerging infections Risk factors NEUROSURGERY Elective surgery Intracranial infections
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Clay mineral compositions in the surface sediment of the Chanthaburi coast(northeastern Gulf of Thailand)and their implications on sediment provenance
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作者 Min CHEN Hongshuai QI +4 位作者 Apitida WASUWATCHARAPONG Apichai KANCHANAPANT Wichien INTASEN Guobiao HUANG xuan liu 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第5期1742-1752,共11页
Clay mineral composition represents an important tracer of sediment source area,migration processes,and paleoclimatic conditions.Clay mineral analysis was performed on 15 surface sediment samples collected from the co... Clay mineral composition represents an important tracer of sediment source area,migration processes,and paleoclimatic conditions.Clay mineral analysis was performed on 15 surface sediment samples collected from the coast of Chanthaburi,Thailand.Results show that the composition of clay minerals in the study area differs substantially from that in surrounding regions of the Gulf of Thailand.The clay minerals of the Chanthaburi coast are dominated by kaolinite(~56%),followed by smectite(~21%),illite(~14%),and low concentrations of chlorite(~8%).The average illite chemistry index and crystallinity are 0.93 and 0.32,respectively.Comparative analysis of the clay mineral composition of surface sediments in several typical areas around the Gulf of Thailand indicated that the clays of the Chanthaburi coast are mainly derived from parent rock weathering in the small watersheds of the Chanthaburi and Welu rivers and the surrounding islands.Terrestrial input from the northern coast of the Gulf of Thailand(excluding the Mekong River)was previously considered negligible;however,the present results indicate that such input has impact on the eastern Gulf of Thailand.The warm humid climatic conditions in Southeast Asia are the primary factors that affect the strong chemical weathering in the study area,followed by the nature of the parent rock. 展开更多
关键词 clay mineral surface sediment PROVENANCE coast of Thailand
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Botanical drugs for bruises used in the Xiangxi region of China, a place rich in martial culture
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作者 Jian-Wu He Hong-Tao Gao +4 位作者 xuan liu Qiang Li Jin Luo Jin Yan Bin-Sheng Luo 《Traditional Medicine Research》 2023年第11期45-54,共10页
Background:Xiangxi Tujia and Miao Autonomous Prefecture,located in Hunan Province,China,is a culturally rich region with a diverse population.The locals have a deep martial arts history and possess a wealth of traditi... Background:Xiangxi Tujia and Miao Autonomous Prefecture,located in Hunan Province,China,is a culturally rich region with a diverse population.The locals have a deep martial arts history and possess a wealth of traditional knowledge for treating bruises.Methods:In order to investigate this topic,we conducted ethnobotanical studies by visiting local medicinal markets and conducting interviews.Results:We identified 43 botanical drugs used for treating bruises,categorized into four types:sprains,contusions,strains,and bone injuries.The local people typically prefer to mash these botanical drugs freshly or make medicinal wine for external use.Treatment often involves a combination of drugs to promote blood circulation and remove blood stasis,with medications to dispel rheumatism,clear heat,and detoxify,tailored to the humid climate and high precipitation in mountainous areas.Based on the fidelity level values,the local plant resources with high acceptance,utilization,or potential value in the treatment of bruises included Sargentodoxa cuneata,Lycopodium japonicum,Dioscorea cirrhosa,Panax japonicus,Achyranthes bidentata,Lysimachia heterogenea and so on.Conclusion:Herbal medicine and related knowledge for treating bruises are diverse and rich in the Xiangxi region.However,the local traditional medicinal knowledge faces challenges regarding inheritance due to regional modernization.Therefore,it is crucial to protect and further study this knowledge in the future. 展开更多
关键词 BRUISES medicinal plants ETHNOBOTANY Xiangxi traditional knowledge
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Improved Blending Attention Mechanism in Visual Question Answering
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作者 Siyu Lu Yueming Ding +4 位作者 Zhengtong Yin Mingzhe liu xuan liu Wenfeng Zheng Lirong Yin 《Computer Systems Science & Engineering》 SCIE EI 2023年第10期1149-1161,共13页
Visual question answering(VQA)has attracted more and more attention in computer vision and natural language processing.Scholars are committed to studying how to better integrate image features and text features to ach... Visual question answering(VQA)has attracted more and more attention in computer vision and natural language processing.Scholars are committed to studying how to better integrate image features and text features to achieve better results in VQA tasks.Analysis of all features may cause information redundancy and heavy computational burden.Attention mechanism is a wise way to solve this problem.However,using single attention mechanism may cause incomplete concern of features.This paper improves the attention mechanism method and proposes a hybrid attention mechanism that combines the spatial attention mechanism method and the channel attention mechanism method.In the case that the attention mechanism will cause the loss of the original features,a small portion of image features were added as compensation.For the attention mechanism of text features,a selfattention mechanism was introduced,and the internal structural features of sentences were strengthened to improve the overall model.The results show that attention mechanism and feature compensation add 6.1%accuracy to multimodal low-rank bilinear pooling network. 展开更多
关键词 Visual question answering spatial attention mechanism channel attention mechanism image feature processing text feature extraction
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细胞因子与肿瘤标志物联合检测对孤立性肺结节良恶性鉴别诊断的价值 被引量:17
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作者 石婕 刘璇 +6 位作者 明宗娟 李维 吕欣 杨侠 王煜 张梦颖 杨拴盈 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第6期426-433,共8页
背景与目的近年来,孤立性肺结节(solitary pulmonary nodule,SPN)受到越来越多的关注,部分肺结节被认为是早期肺癌,但如何鉴别肺结节良恶性却是亟待解决的临床难题。本研究旨在探讨细胞因子与肿瘤标志物联合检测对SPN良恶性的鉴别诊断价... 背景与目的近年来,孤立性肺结节(solitary pulmonary nodule,SPN)受到越来越多的关注,部分肺结节被认为是早期肺癌,但如何鉴别肺结节良恶性却是亟待解决的临床难题。本研究旨在探讨细胞因子与肿瘤标志物联合检测对SPN良恶性的鉴别诊断价值,从而提高SPN诊断的准确性。方法纳入81例诊断明确的SPN患者作为研究对象,收集病例的一般临床资料、结节影像学特征、病理学诊断资料、细胞因子系列和肿瘤标志物表达水平。利用单因素和多因素分析筛选可预测肺结节性质的影响指标,并用二元Logistic回归分析构造联合指标;绘制受试者工作特征曲线(receiver operating characteristic curve,ROC),计算曲线下面积及相应的灵敏度、特异度、阳性预测值、阴性预测值和准确率。结果一般临床资料分析示恶性结节出现在右肺上叶的比例最高(40.4%)。恶性结节组中的癌胚抗原(carcinoembryonic antigen,CEA)、细胞角蛋白19片段(cytokeratin 19 fragment 21-1,CYFRA21-1)、白介素6(interleukin-6,IL-6)和白介素8(interleukin-8,IL-8)血清水平高于良性结节组。Logistic回归分析提示,CEA、IL-6、IL-8为预测恶性结节的独立危险因子。ROC曲线分析表明,单项指标CEA、IL-6和IL-8的曲线下面积分别为0.642、0.684和0.749,CEA+IL-6+IL-8联合检测曲线下面积更大,检测效能更高。结论CEA、IL-6和IL-8为恶性结节的独立危险因素。细胞因子和肿瘤标志物联合检测在SPN良恶性鉴别诊断中具有一定的价值。其中CEA+IL-6+IL-8联合检测的诊断价值最高。 展开更多
关键词 孤立性肺结节 肿瘤标志物 细胞因子 联合检测 诊断
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