Bone regeneration is a crucial part in the treatment of periodontal tissue regeneration,in which new attempts come out along with the development of nanomaterials.Herein,the effect of cerium oxide nanoparticles(CeO_(2...Bone regeneration is a crucial part in the treatment of periodontal tissue regeneration,in which new attempts come out along with the development of nanomaterials.Herein,the effect of cerium oxide nanoparticles(CeO_(2)NPs)on the cell behavior and function of human periodontal ligament stem cells(hPDLSCs)was investigated.Results of CCK-8 and cell cycle tests demonstrated that CeO_(2)NPs not only had good biocompatibility,but also promoted cell proliferation.Furthermore,the levels of alkaline phosphatase activity,mineralized nodule formation and expressions of osteogenic genes and proteins demonstrated CeO_(2)NPs could promote osteogenesis differentiation of hPDLSCs.Then we chose electrospinning to fabricate fibrous membranes containing CeO_(2)NPs.We showed that the composite membranes improved mechanical properties as well as realized release of CeO_(2)NPs.We then applied the composite membranes to in vivo study in rat cranial defect models.Micro-CT and histopathological evaluations revealed that nanofibrous membranes with CeO_(2)NPs further accelerated new bone formation.Those exciting results demonstrated that CeO_(2)NPs and porous membrane contributed to osteogenic ability,and CeO_(2)NPs contained electrospun membrane may be a promising candidate material for periodontal bone regeneration.展开更多
The detection mission of gravitational waves in space is that the accuracy of the long-baseline intersatellite laser interferometry on the million-kilometer order needs to reach the order of 8 pm/Hz.Among all noise so...The detection mission of gravitational waves in space is that the accuracy of the long-baseline intersatellite laser interferometry on the million-kilometer order needs to reach the order of 8 pm/Hz.Among all noise sources that affect the interferometry accuracy,tilt-to-length(TTL)coupling noise is the second largest source of noise after shot noise.This paper focuses on studying the contribution of TTL coupling noise of the telescope system in the intersatellite scientific interferometer.By referring to the laser interferometer space antenna(LISA)’s noise budget,TTL coupling noise is required to be within±25μm/rad(±300μrad).Therefore,this paper focuses on studying both the mechanism of TTL coupling noise due to the noise sources of the telescope and the method of suppressing the TTL noise,which can lay a foundation for noise distribution and the development of engineering prototypes in subsequent tasks.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.82001049,81771074)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD,2018-87)+1 种基金the Natural Science Foundation of Jiangsu Province(BK.20200665)The authors are grateful to Professor Yong Hu(Nanjing University)for his critical support on electrospinning technology and valuable discussion of the project.
文摘Bone regeneration is a crucial part in the treatment of periodontal tissue regeneration,in which new attempts come out along with the development of nanomaterials.Herein,the effect of cerium oxide nanoparticles(CeO_(2)NPs)on the cell behavior and function of human periodontal ligament stem cells(hPDLSCs)was investigated.Results of CCK-8 and cell cycle tests demonstrated that CeO_(2)NPs not only had good biocompatibility,but also promoted cell proliferation.Furthermore,the levels of alkaline phosphatase activity,mineralized nodule formation and expressions of osteogenic genes and proteins demonstrated CeO_(2)NPs could promote osteogenesis differentiation of hPDLSCs.Then we chose electrospinning to fabricate fibrous membranes containing CeO_(2)NPs.We showed that the composite membranes improved mechanical properties as well as realized release of CeO_(2)NPs.We then applied the composite membranes to in vivo study in rat cranial defect models.Micro-CT and histopathological evaluations revealed that nanofibrous membranes with CeO_(2)NPs further accelerated new bone formation.Those exciting results demonstrated that CeO_(2)NPs and porous membrane contributed to osteogenic ability,and CeO_(2)NPs contained electrospun membrane may be a promising candidate material for periodontal bone regeneration.
基金This work is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA15020000).
文摘The detection mission of gravitational waves in space is that the accuracy of the long-baseline intersatellite laser interferometry on the million-kilometer order needs to reach the order of 8 pm/Hz.Among all noise sources that affect the interferometry accuracy,tilt-to-length(TTL)coupling noise is the second largest source of noise after shot noise.This paper focuses on studying the contribution of TTL coupling noise of the telescope system in the intersatellite scientific interferometer.By referring to the laser interferometer space antenna(LISA)’s noise budget,TTL coupling noise is required to be within±25μm/rad(±300μrad).Therefore,this paper focuses on studying both the mechanism of TTL coupling noise due to the noise sources of the telescope and the method of suppressing the TTL noise,which can lay a foundation for noise distribution and the development of engineering prototypes in subsequent tasks.
