Stability analysis of a slope containing water-sensitive mudstone considering different rainfall conditions at an open-pit mine

Mudstone, as a typical soft rock with wide distribution, has been endangering the slopes containing mudstone by its watersensitivity of swelling and weakening strength when encountering water. To comprehensively understand the water-sensitivity of mudstone and reveal its infuence on slope stability, we took the working slope containing water-sensitive mudstone of Shengli No.1 open-pit coal mine in Xilinhot, Inner Mongolia, China, as an example. Mudstone samples taken from the working slope were remodeled and saturated, and then triaxial tested to obtain the efective cohesion and efective internal friction angle. The flter paper method was used to obtain the soil–water characteristic curve of unsaturated mudstone. The pore structure of mudstone samples with diferent water contents were analyzed using the mercury intrusion porosimetry tests combined with the fractal dimension. The total pore content of the mudstone sample with lower water content is greater than that of the mudstone sample with higher water content. The mesopores are more in the mudstone sample with lower water content, while the small pores are more in the mudstone sample with higher water content. The variation of water content will change the complexity of mudstone pore structure. The higher the water content, the simpler the mudstone pore structure and the smoother the pore surface. Numerical calculations were conducted on the stability of the working slope under diferent rainfall conditions. The efective saturation on the mudstone layer surface changed and the plastic strain all occurred on the mudstone steps under diferent rainfall conditions. The key to preventing landslide of the slope containing water-sensitive mudstone in Shengli No.1 open-pit coal mine is to control the deformation and sliding of the mudstone layer.

Formation of Low-Level Jets over Southern China in the Mei-yu Season

This study examines the diversity of low-level jet(LLJ)formation and related physical processes over southern China.A total of 171 LLJ formation events with enhanced daily southwesterlies and early-morning maximum wind speeds were observed during the mei-yu seasons of 1989–2018.The LLJs can be further categorized into four types based on the increases in the daily mean and diurnal amplitude of the low-level winds.Analysis of the synoptic-scale disturbances shows that the two types of LLJ formation(Q1 and Q4),which feature large increases of daily southerly wind components,are mainly induced by west-east dipole patterns of pressure change,in association with the enhanced southwest vortex and/or the western Pacific subtropical high(WPSH).In contrast,the other two types(Q2 and Q3),which feature relatively large increases in their daily westerly components,are related to a northwest-southeast dipole pattern of pressure change due to the mid-latitude trough and the WPSH.We further analyze the considerable variations in the diurnal thermal forcing among the LLJ formation events.The strong(weak)daytime heating of solar radiation leads to relatively large(small)increases in the diurnal amplitude of low-level winds in Q1 and Q2(Q3 and Q4)types.Therefore,different combinations of synopticscale disturbances and diurnal thermal forcings are found to account for the diversity in LLJ formation and associated differences in downstream rainfall patterns.These results help to improve our understanding and prediction of the formation of LLJs.

Whole exome sequencing in 186 sporadic transposition of the great arteries cases reveals extensive and complex genetic etiology

Background and Objective(TGA)is a rare life-threatening form of congenital heart disease(CHD)with little known etiology.The recurrence rate in siblings and offspring of TGA patients has been observed higher than general population,implying the contribution of genetic factors.Indeed,family studies identified copy number variants e.g.22q11.2 deletions and point mutations e.g.NKX2-5 underlying genetic susceptibility to TGA or other forms of CHD.However,these genetic variants revealed in family studies are seldom observed in sporadic TGA subjects,indicating a distinct genetic etiology in sporadic TGA that remains to be explored.We sought to explore the genetic etiology of sporadic TGA at different levels including mutations,genes and pathways.

Progress in cancer therapy with functionalized Fe_(3)O_(4) nanomaterials

Malignant neoplasms represent a significant global health threat.To address the need for accurate diagnosis and effective treatment,research is underway to develop therapeutic nanoplatforms.Iron oxide nanoparticles(NPs),specifically Fe_(3)O_(4) NPs have been extensively studied as potential therapeutic agents for cancer due to their unique properties including magnetic targeting,favorable biocompatibility,high magnetic response sensitivity,prolonged in vivo circulation time,stable performance,and high self-metabolism.Their ability to be integrated with magnetic hyperthermia,photodynamic therapy,and photothermal therapy has resulted in the widespread use of Fe_(3)O_(4) NPs in cancer diagnosis and treatment,making them a popular choice for such applications.Various methods can be employed to synthesize magnetic Fe_(3)O_(4) NPs,which can then be surface-modified with biocompatible materials or active targeting molecules.Multifunctional systems can be created by combining Fe_(3)O_(4) NPs with polymers.By combining various therapeutic approaches,more effective biomedical materials can be developed.This paper discusses the synthesis of Fe_(3)O_(4) NPs and the latest research advances in Fe_(3)O_(4)-based nanotherapeutic platforms,as well as their applications in the biomedical field.

Silting Objects over the Stable Monomorphism Category of Higher Differential Objects

Higher differential objects are investigated and used for addressing three gen-eral problems.Torsionless differential modules over path algebras are characterized.The adjoint triples between triangulated categories,involving derived categories and singularity categories,are allowed to be constructed from those between the abelian categories C and C[ε]^(n).The partial silting properties between an abelian category C and C[ε]^(n)are trans-ferred,and if moreover,C is Frobenius,the partial silting objects of the stable monomor-phism categories of C[ε]^(n)are constructed from those of C.

有机自旋阀及其磁电阻效应

随着巨磁电阻效应(GMR)的发现,自旋电子学迅速兴起并成为一门新的学科。自旋电子学以电子的自旋属性为信息载体,有望实现集逻辑、存储和通信于一体的多功能、低功耗器件,为下一代电子学开辟新的路径。有机半导体具有低自旋轨道耦合、弱超精细相互作用和长自旋弛豫时间等特点,因而受到了极大关注。有机自旋阀(OSVs)是研究有机材料中自旋注入和传输的原型器件。本文综述了有机自旋阀的发展历程,总结了有机半导体的自旋弛豫机制,详细分析了有机自旋阀中存在的关键科学问题,如室温自旋传输的实现策略和磁电阻符号问题,介绍了自旋有机发光二极管和自旋光伏器件等新型自旋器件,最后对有机自旋电子学未来发展进行了展望。

浸渍提拉法制备连续、高度有序有机半导体薄膜:弯月面角的关键作用

浸渍提拉法是一种低成本、大面积、高效制备有机半导体薄膜的技术.针对该技术中提拉速度、溶剂类型、溶液浓度等参数的研究报道已很多.但由于忽略了提拉过程中溶液-衬底相互作用这个关键因素,提拉得到的沉积物绝大多数为带状或树枝状晶体,覆盖率较低.本文提出用弯月面角(MA)来量化浸渍提拉过程中溶液与衬底的实时相互作用的强弱.通过对衬底进行适当的表面处理,可以调节MA值,从而可以获得厘米级、连续、高度有序的有机半导体薄膜,并构建了有机场效应晶体管(OFETs),研究了连续薄膜的电荷输运特性.最大(平均)空穴迁移率可达11.9(5.1)cm2V-1s-1.统计显示连续薄膜的平均迁移率比带状晶体高82%,表明所制备的薄膜具有高结晶度.该工作揭示了浸渍提拉过程中动态溶液-衬底相互作用在薄膜沉积过程中扮演的关键角色,给出了衡量二者之间相互作用强弱的量化指标,为浸渍提拉法制备大面积、连续、高度有序的有机半导体薄膜的研究及其在各种光电器件领域的应用提供了理论和技术支撑.

Analysis of factors affecting microwave heating of natural gas hydrate combined with numerical simulation method

As a clean and abundant unconventional natural gas resource,natural gas hydrate(NGH)holds the characteristics of safety,high efficiency and sustainable exploitation,which helps to alleviate the energy shortage of China,reduce the foreign-trade dependence of oil and gas,and ensure the national energy security.Microwave heating is a significant method that has been used in natural gas hydrate exploration.By using the microwave heating,the NGH in the reservoir formations would be heated,decomposed and stimulated thanks to taking advantage of microwave heating's unique characters:efficiency,high speed,clean and pollution-free.This paper established the temperature under microwave heating gas hydrate distribution theory model,and by using the finite element method for simulating temperature field of microwave heating gas hydrate,this paper analyzed the natural gas hydrate in the microwave field temperature distribution in the influencing factors.Microwave has a significant heating effect on the hydrate reservoir in the immediate vicinity of wellbore,and it is not affected by the initial conditions of reservoir.The temperature can rise to above 50℃ within 1 h which is higher than the phase equilibrium temperature at the time of hydrate decomposition and is helpful to improve the decomposition rate of hydrate.The frequency is set at 915 MHz,and the feed port has a spiral arrangement with a length of 10 mm,which greatly expands the microwave heating range.