Role of TSH Inhibition Therapy in the Postoperative Management of Patients with Differentiated Thyroid Cancer

Objective:To investigate the effect of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer.Methods:Seventy patients diagnosed with differentiated thyroid cancer were selected for the study.TSH inhibition therapy was administered to the research group,while thyroxine replacement therapy was provided to the control group during the postoperative management phase.This allowed for a comparative analysis between the two groups.Results:In comparison with the control group,the research group exhibited significant decreases in serum TSH,T3,and T4 levels after treatment,while FT4 and FT3 levels significantly increased(P<0.05).Additionally,significant decreases in Tg,VEGF,TSGF,CD44V6,and sIL-2R levels were observed in the research group after treatment(P<0.05).No significant differences were found in pre-treatment thyroid function between the two groups(P>0.05).Conclusion:The application of TSH inhibition therapy in the postoperative management of patients with differentiated thyroid cancer demonstrates promising outcomes.

Effect of TSH Suppression Therapy on Sex Hormone Levels after Thyroid Cancer Surgery

Objective:To analyze the effect of thyroid-stimulating hormone(TSH)suppression therapy on sex hormone levels in patients undergoing postoperative treatment for thyroid cancer.Methods:A total of 40 patients undergoing postoperative thyroid cancer treatment were selected for data analysis.TSH suppression therapy was implemented during the postoperative period.Patients were grouped according to the TSH level:TSH<0.1,0.1≤TSH<0.5,and TSH≥0.5.Results:Among male patients,there were no significant differences in sex hormone levels at different dosing times and TSH levels(P>0.05).For female patients,testosterone levels at different dosing times showed no significant differences under the same circumstances(P>0.05).The comparison of testosterone levels at different TSH levels over 5 years of TSH suppression therapy did not yield significant differences(P>0.05).However,the comparison of testosterone levels within 5 years of TSH suppression therapy yielded significant differences(P<0.05),with the lowest levels observed at 0.1≤TSH<0.5.Conclusion:The use of TSH suppression therapy in postoperative thyroid cancer treatment minimally affects sex hormone levels in male patients.However,it has a significant impact on female patients.Therefore,preoperative sex hormone testing is recommended,and postoperative monitoring should include regular sex hormone testing.

Parameter optimization of control system design for uncertain wireless power transfer systems using modified genetic algorithm

The closed-loop wireless power transfer(WPT)system can realize constant voltage output in the presence of perturbation.However,the parameter design of the controller is a difficult problem.The traditional trial-and-error method is time-consuming and difficult to find optimal parameters.A parameter optimization strategy of control systems for uncertain WPT systems using the modified genetic algorithm(MGA)is proposed.Firstly,because the system has different characteristics at different periods,the simulation process is divided into three stages.The first one is the start-up stage,in which we mainly consider the overshoot and the rate of the voltage rise.The second one is the tracking stage,in which the tracking time and switching loss are mainly considered.The third one is the stabilisation stage,in which the steady-state error and switching loss are mainly considered.Secondly,three cost functions are designed according to the characteristics of the three stages,and then the optimal controller parameters of each stage are obtained by using MGA.Finally,the effectiveness of the proposed method is verified by simulation.The optimization results show that compared with the previous parameter optimization method,the optimal controller parameters obtained by the proposed method make the WPT system achieve better performance.

Underwater pulsed spark discharge influenced by the relative position between the top of a pin electrode and an insulating tube

Needle-to-plane geometry has been widely investigated and used in underwater pulsed discharges.The position relationship between the needle tip and insulation layer significantly affects the discharge patterns.We carried out experiments on underwater pulsed discharge with the needle tip protruding from,recessing into,and flushing with the insulating tube.The results are as follows.First,underwater pulsed discharge has a strong randomness under the experimental conditions.Different discharge patterns appeared under the same experimental environment.Second,recession into the insulator surface led to a higher probability of occurrence but a lower strength of spark discharge than protrusion.Third,between the needle tip protruding from and recessing into the insulation material,the average speed of propagation of underwater pulsed spark discharge decreased by an order of magnitude.The study shows that the optimum length of needle tip protruding from the insulation layer is 1 mm to obtain a strong underwater pulsed spark discharge.

基于三维可视化技术的脾门区脾动脉三维分型

目的探讨基于三维可视化技术(3DVT)的脾门区脾动脉(SA)三维分型。方法本研究对象为2018年6月至2021年6月在安徽医科大学第一附属医院及皖南医学院附属弋矶山医院诊治的100例患者CT检查影像学资料。患者均签署知情同意书,符合医学伦理学规定。其中男61例,女39例;年龄49~88岁,中位年龄63岁。所有患者行薄层增强CT扫描,提取数据导入三维可视化系统进行三维重建。观察SA分支数目、分布范围、立体走行,与胰尾末端及脾门的空间位置关系,进行三维可视化分型。结果100例脾门区SA、脾脏、胰腺三维模型重建成功率均为100%(100/100)。SA一级分支数目为1支者4例(4%),2支76例(76%),3支15例(15%),多支(≥4支)5例(5%)。SA总分支点与脾门的距离为0~68 mm,中位数为19 mm。SA总分支点与胰尾末端的距离为0~127 mm,中位数为16 mm。脾门与胰尾的距离为0~138 mm,中位数为21 mm。SA分为5型:A型4例(4%),B型76例(76%),C型16例(16%),D型2例(2%),E型2例(2%)。结论脾门区解剖结构复杂多变,术前采用3DVT可对SA末端分支观察和个体化分型,该分型对临床实施精准个体化脾脏和胰腺手术具有一定指导意义。

Integrated contra‑directionally coupled chirped Bragg grating waveguide with a linear group delay spectrum

Due to the advantages of low propagation loss,wide operation bandwidth,continuous delay tuning,fast tuning speed,and compact footprints,chirped Bragg grating waveguide has great application potential in wideband phased array beamforming systems.However,the disadvantage of large group delay error hinders their practical applications.The nonlinear group delay spectrum is one of the main factors causing large group delay errors.To solve this problem,waveguides with nonlinear gradient widths are adopted in this study to compensate for the nonlinear efect of the grating apodization on the mode efective index.As a result,a linear group delay spectrum is obtained in the experiment,and the group delay error is halved.

A broadband integrated microwave photonic mixer based on balanced photodetection

An integrated microwave photonic mixer based on silicon photonic platforms is proposed,which consist of a dual-drive Mach–Zehnder modulator and a balanced photodetector.The modulated optical signals from microwave photonic links can be directly demodulated and down-converted to intermediate frequency(IF)signals by the photonic mixer.The converted signal is obtained by conducting of-chip subtraction of the outputs from the balanced photodetector,and subsequent fltering of the high frequency items by an electrical low-pass flter.Benefting from balanced detection,the conversion gain of the IF signal is improved by 6 dB,and radio frequency leakage and common-mode noise are suppressed signifcantly.System-level simulations show that the frequency mixing system has a spurious-free dynamic range of 89 dB·Hz^(2/3),even with deteriorated linearity caused by the two cascaded modulators.The spur suppression ratio of the photonic mixer remains higher than 40 dB when the IF varies from 0.5 to 4 GHz.The electrical-electrical 3 dB bandwidth of frequency conversion is 11 GHz.The integrated frequency mixing approach is quite simple,requiring no extra optical flters or electrical 90°hybrid coupler,which makes the system more stable and with broader bandwidth so that it can meet the potential demand in practical applications.

用计算成像扩大卡塞格林系统视场的方法

卡塞格林光学系统的结构严重限制了视场,通常需添加辅助光学元件来扩大视场,但将导致系统结构复杂,不利于光学系统的小型化、轻量化。提出一种计算成像设计方法,首先优化系统结构参数,控制像差;然后构建系统的点扩展函数模型;最后采用反卷积算法处理图像。所提方法仅利用主、次镜结构就扩大了卡塞格林系统的视场。对F数为5.5,焦距为470 mm的卡塞格林系统进行仿真实验,实验结果表明,在1.5°视场范围内,处理后图像的轴外视场调制传递函数在20 lp/mm处提升了约0.2,图像质量得到明显提升。

Real-time evaluation method of flight mission load based on sensitivity analysis of physiological factors

As the complexity of flight missions continues to increase,sending a timely warning or providing assistance to pilots helps to reduce the probability of operational errors and flight accidents.Monitoring pilots’physiological data,real-time evaluation of mission load is a feasible technical way to achieve this.In this paper,a set of flight tasks including aircraft control,humancomputer interaction and mental arithmetic tests are designed to simulate five mission loads at different flight difficulty levels.A sensitivity analysis method based on a comprehensive test is proposed to select a set of sensitive physiological factors.Then,based on the SVM hierarchical combination classification method,the pilot mission load real-time evaluation model is established.The test results show significant differences in EMG,respiration rate(abdomen),heart rate,blood oxygen saturation,pupil area,fixation duration,number of fixations,and saccades.The high accuracy obtained from experiments proved that the proposed real-time evaluation model is applicable to meet the requirements of real working environments.The findings can provide methodological references for mission load evaluation research in other fields.

DG polynomial algebras and their homological properties

In this paper, we introduce and study differential graded(DG for short) polynomial algebras. In brief, a DG polynomial algebra A is a connected cochain DG algebra such that its underlying graded algebra A~# is a polynomial algebra K[x_1, x_2,..., x_n] with |xi| = 1 for any i ∈ {1, 2,..., n}. We describe all possible differential structures on DG polynomial algebras, compute their DG automorphism groups, study their isomorphism problems, and show that they are all homologically smooth and Gorenstein DG algebras. Furthermore, it is proved that the DG polynomial algebra A is a Calabi-Yau DG algebra when its differential ?_A≠ 0 and the trivial DG polynomial algebra(A, 0) is Calabi-Yau if and only if n is an odd integer.