由于“一带一路”的开放性决策,许多共建“一带一路”国家的留学研究生进入南京医科大学学习。由于留学研究生的文化背景存在诸多差异,给留学研究生的教学带来一定挑战。基于传统课堂教学方法的改革是提高留学研究生课堂效果的必要途径...由于“一带一路”的开放性决策,许多共建“一带一路”国家的留学研究生进入南京医科大学学习。由于留学研究生的文化背景存在诸多差异,给留学研究生的教学带来一定挑战。基于传统课堂教学方法的改革是提高留学研究生课堂效果的必要途径,也是我校作为新一批“双一流”高校的必然要求。“共情-模块化”方法是在充分调研、了解留学研究生的背景前提下,根据不同研究生的知识基础、文化背景,模块化设置课程内容,精准对标留学研究生的知识薄弱点,提高课程成绩及课堂教学效果。以“Principles and Methods of Clinical and Translational Medicine”(PMCT)为例,在教学实践中,深入剖析“共情-模块化”方法的主要特点、关键环节和存在问题;进一步探索后疫情时代下,针对留学研究生采用“共情-模块化”教学方法的可行性;最终建立健全来华留学研究生的教学方法以及常态化育人体系。展开更多
Background: Prolonged exposure to environmental toxicants like endocrine-disrupting chemicals has been linked to several ovarian pathologies. Exposure to endocrine-disrupting chemicals may start at any time of life fr...Background: Prolonged exposure to environmental toxicants like endocrine-disrupting chemicals has been linked to several ovarian pathologies. Exposure to endocrine-disrupting chemicals may start at any time of life from the fetal stage to adulthood resulting in various health complications The purpose of our study is to compare the concentration levels and association of benzopyrene, bisphenol A and genistein in patients with ovarian tumors and normal control group. We also sort to evaluate the predictive performance of benzopyrene, bisphenol A and genistein in patients with ovarian tumors. Methods: A case-control study was conducted for randomly selected participants involving 30 patients and 30 controls. 30 patients with radiologically diagnosed and histopathological confirmed ovarian tumors were included in the study between January 2022 and December 2022. Urine samples from each group were analyzed using liquid chromatography-mass spectrometry. Descriptive analysis for normally distributed continuous variables was done accordingly. Concentration levels of endocrine-disrupting chemicals were assessed using the Mann-Whitney test. The association of endocrine-disrupting chemicals with pathological ovarian tumors was analyzed using binary logistic regression. Evaluation of the diagnostic performance of endocrine-disrupting chemicals was analyzed using the ROC curve. Results: Overall, patients were significantly (P = 0.000) older than the healthy controls. Mean years (SD) were 36.7 (7.90) and 28.8 years (4.89) for patients and normal women respectively. Endometriomas had the highest incidence of 50%. The level of benzopyrene and bisphenol A in patients was significantly higher than those in the control group, while the level of genistein was significantly higher in normal controls. Benzopyrene and bisphenol A were significantly associated with ovarian cysts, and the incidence of pathological ovarian cysts was positively correlated to these EDCs, with OR value 64.79 (P = 0.005) for benzopyrene and 9.609 (P = 0.001) for bisphenol A. Genistein was significantly negatively correlated with the incidence of pathological ovarian tumors, with OR value of 0.153 (P = 0.007). Diagnostic performance on the AUC for benzopyrene, bisphenol A and genistein&l.展开更多
应对全球气候变化、人类健康、水资源供给、生态环境保护与可持续发展等全世界共同关心的重大问题,加强湖泊科学领域的国际合作研究,既是重大的科学命题,也是关乎区域生态安全、人类生存环境和社会经济发展的重大战略需求。本文基于Web ...应对全球气候变化、人类健康、水资源供给、生态环境保护与可持续发展等全世界共同关心的重大问题,加强湖泊科学领域的国际合作研究,既是重大的科学命题,也是关乎区域生态安全、人类生存环境和社会经济发展的重大战略需求。本文基于Web of Science SCIE数据库,采用文献计量学方法,对2001—2020年湖泊科学领域国际合作文献进行了定量分析和数据挖掘,并选取国际上7家代表性湖泊专业研究机构进行了国际合作重点团队和重点合作研究内容的比较分析,在此基础上探讨了湖泊科学国际合作的重点研究方向和发展趋势。研究表明,湖泊科学领域国际合作研究趋于活跃,特别是近十年来国际合作程度明显上升,国际合作格局显著变化,中国在该领域国际合作关系中占有重要的地位;欧美湖泊研究机构的重点国际合作团队影响力普遍较高,我国团队产出需要实现从“量”到“质”的转变;国际合作研究的热点内容主要体现在多学科交叉和宏观与微观结合、人与湖泊环境协调及湖泊流域综合管理、湖泊生态退化及其修复、对全球气候环境变化响应等多个方面。论文进一步提出了关于加强我国湖泊科学领域国际合作研究的建议。展开更多
文摘由于“一带一路”的开放性决策,许多共建“一带一路”国家的留学研究生进入南京医科大学学习。由于留学研究生的文化背景存在诸多差异,给留学研究生的教学带来一定挑战。基于传统课堂教学方法的改革是提高留学研究生课堂效果的必要途径,也是我校作为新一批“双一流”高校的必然要求。“共情-模块化”方法是在充分调研、了解留学研究生的背景前提下,根据不同研究生的知识基础、文化背景,模块化设置课程内容,精准对标留学研究生的知识薄弱点,提高课程成绩及课堂教学效果。以“Principles and Methods of Clinical and Translational Medicine”(PMCT)为例,在教学实践中,深入剖析“共情-模块化”方法的主要特点、关键环节和存在问题;进一步探索后疫情时代下,针对留学研究生采用“共情-模块化”教学方法的可行性;最终建立健全来华留学研究生的教学方法以及常态化育人体系。
文摘Background: Prolonged exposure to environmental toxicants like endocrine-disrupting chemicals has been linked to several ovarian pathologies. Exposure to endocrine-disrupting chemicals may start at any time of life from the fetal stage to adulthood resulting in various health complications The purpose of our study is to compare the concentration levels and association of benzopyrene, bisphenol A and genistein in patients with ovarian tumors and normal control group. We also sort to evaluate the predictive performance of benzopyrene, bisphenol A and genistein in patients with ovarian tumors. Methods: A case-control study was conducted for randomly selected participants involving 30 patients and 30 controls. 30 patients with radiologically diagnosed and histopathological confirmed ovarian tumors were included in the study between January 2022 and December 2022. Urine samples from each group were analyzed using liquid chromatography-mass spectrometry. Descriptive analysis for normally distributed continuous variables was done accordingly. Concentration levels of endocrine-disrupting chemicals were assessed using the Mann-Whitney test. The association of endocrine-disrupting chemicals with pathological ovarian tumors was analyzed using binary logistic regression. Evaluation of the diagnostic performance of endocrine-disrupting chemicals was analyzed using the ROC curve. Results: Overall, patients were significantly (P = 0.000) older than the healthy controls. Mean years (SD) were 36.7 (7.90) and 28.8 years (4.89) for patients and normal women respectively. Endometriomas had the highest incidence of 50%. The level of benzopyrene and bisphenol A in patients was significantly higher than those in the control group, while the level of genistein was significantly higher in normal controls. Benzopyrene and bisphenol A were significantly associated with ovarian cysts, and the incidence of pathological ovarian cysts was positively correlated to these EDCs, with OR value 64.79 (P = 0.005) for benzopyrene and 9.609 (P = 0.001) for bisphenol A. Genistein was significantly negatively correlated with the incidence of pathological ovarian tumors, with OR value of 0.153 (P = 0.007). Diagnostic performance on the AUC for benzopyrene, bisphenol A and genistein&l.
文摘应对全球气候变化、人类健康、水资源供给、生态环境保护与可持续发展等全世界共同关心的重大问题,加强湖泊科学领域的国际合作研究,既是重大的科学命题,也是关乎区域生态安全、人类生存环境和社会经济发展的重大战略需求。本文基于Web of Science SCIE数据库,采用文献计量学方法,对2001—2020年湖泊科学领域国际合作文献进行了定量分析和数据挖掘,并选取国际上7家代表性湖泊专业研究机构进行了国际合作重点团队和重点合作研究内容的比较分析,在此基础上探讨了湖泊科学国际合作的重点研究方向和发展趋势。研究表明,湖泊科学领域国际合作研究趋于活跃,特别是近十年来国际合作程度明显上升,国际合作格局显著变化,中国在该领域国际合作关系中占有重要的地位;欧美湖泊研究机构的重点国际合作团队影响力普遍较高,我国团队产出需要实现从“量”到“质”的转变;国际合作研究的热点内容主要体现在多学科交叉和宏观与微观结合、人与湖泊环境协调及湖泊流域综合管理、湖泊生态退化及其修复、对全球气候环境变化响应等多个方面。论文进一步提出了关于加强我国湖泊科学领域国际合作研究的建议。
