Editorial Commentary:Association of Comorbid Asthma and the Efficacy of Bioabsorbable Steroid-eluting Sinus Stents Implanted after Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis with Nasal Polyps

Chronic rhinosinusitis with nasal polyps(CRSw-NP)is a multifactorial and heterogeneous disorder of the sinonasal mucosa,characterized by a high relapse rate after medical and surgical treatments[1].Endoscopic sinus surgery(ESS)is the preferred treatment for CRSwNP in patients who have failed to respond to medical therapy[2].However,the postoperative complications will impair the recovery of patients,and accompanying post-operative outpatient visits may contribute to patient discomfort[3]Suppressing postoperative mucosa edema and improving mucosa recovery is critical to reducing the disease relapse after ESS.The steroid-eluting sinus stent(SESS)represents a promising emerging therapy for CRSwNP.

Using the internet search data to investigate symptom characteristics of COVID-19: A big data study

Objective:Analyzing the symptom characteristics of Coronavirus Disease 2019(COVID-19)to improve control and prevention.Methods:Using the Baidu Index Platform(http://index.baidu.com)and the website of Chinese Center for Disease Control and Prevention as data resources to obtain the search volume(SV)of keywords for symptoms associated with COVID-19 from January 1 to February 20 in each year from 2017 to 2020 and the epidemic data in Hubei province and the other top 9 impacted provinces in China.Data of 2020 were compared with those of the previous three years.Data of Hubei province were compared with those of the other 9 provinces.The differences and characteristics of the SV of COVID-19-related symptoms,and the correlations between the SV of COVID-19 and the number of newly confirmed/suspected cases were analyzed.The lag ef-fects were discussed.Results:Comparing the SV from January 1,2020 to February 20,2020 with those for the same period of the previous three years,Hubei’s SV for cough,fever,diarrhea,chest tightness,dys-pnea,and other symptoms were significantly increased.The total SV of lower respiratory symptoms was significantly higher than that of upper respiratory symptoms(P<0.001).The SV of COVID-19 in Hubei province was significantly correlated with the number of newly confirmed/suspected cases(rconfirmed Z 0.723,rsuspected Z 0.863,both p<0.001).The results of the distributed lag model suggested that the patients who searched relevant symptoms on the Internet may begin to see doctors in 2e3 days later and be confirmed in 3e4 days later.Conclusion:The total SV of lower respiratory symptoms was higher than that of upper respira-tory symptoms,and the SV of diarrhea also increased significantly.It warned us to pay atten-tion to not only the symptoms of the lower respiratory tract but also the gastrointestinal symptoms,especially diarrhea in patients with COVID-19.Internet search behavior had a pos-itive correlation with the number of newly confirmed/suspected cases,suggesting that big data has an important role in the early warning of infectious diseases.

Glutathione S-transferase P1 IlelO5Val Polymorphism and Male Infertility Risk： An Updated Meta-analysis

Background： Several studies concerning the association between glutathione S-transferase P1 （GSTP1） Ilel05Val polymorphism and male infertility risk have reported controversial findings. The present study was aimed to explore this association using a recta-analysis. Methods： The PubMed, EMBASE, China National Knowledge Infrastructure （CNKI）, and Wanfang databases were searched. Odds ratios （ORs） with 95% confidence intervals （C/s） were calculated to estimate the strength of the association. Results： A total of 3282 cases and 3268 controls in nine case-control studies were included. There was no significant association between GSTP1 llel05Val polymorphism and male infertility in the overall population, but significant associations were lbund under the dominant （OR = 1.23, 95% CI = 1.04-1.46, F = 32.2%） and heterozygote （OR = 1.29, 95% C1 - 1.08-1.53, F = 26.8%） models after excluding studies for which the data did not satisfy Hardy-Weinberg equilibrium （HWE）. Similarly, subgroup analyses revealed no significant association in Asians or Chinese population although a significant association was apparent among Chinese population in studies with HWE under the heterozygote model （OR = 1.25, 95% CI = 1.03-1.52, F = 44.1%）. Significant heterogeneity could be observed in some genetic models, but this heterogeneity was not significant when stratified by HWE. No evidence for publication bias was found. Conclusions： The GS-FP1 lle105Val polymorphism might not be associated with male infertility risk, and thus additional well-designed studies with larger sample size are warranted.