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Polymorphism of CYPIAl and GSTMl genes associated with susceptibility of gastric cancer in Shandong Province of China 被引量:9
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作者 Hao Li xue-liang chen Hui-Qing Li 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第37期5757-5762,共6页
AIM: To explore whether polymorphisms of the CYPIA1 and GSTM1 genes are associated with susceptibility of stomach cancer. METHODS: A total of 102 stomach cancer cases and 62 healthy persons were diagnosed by patholo... AIM: To explore whether polymorphisms of the CYPIA1 and GSTM1 genes are associated with susceptibility of stomach cancer. METHODS: A total of 102 stomach cancer cases and 62 healthy persons were diagnosed by pathology in 1998- 2000 in the Qilu Hospital of Shandong University. Gene polymorphisms were detected by the PCR using sequencespecific primers. Data analysis of the case-control study was carried out using the unconditional logistic method. RESULTS: After adjustment for age, sex, educational levels, and occupation, the risk factors for stomach cancer were shown to be smoking, Helicobacter pylori (H pylon), and presence of the CYPIM G/G and GSTM1O/O genotypes. Interaction was observed between the combined genotypes of either CYPIA1 G/G and GSTM1O/O or Hpyloriinfection, or GSTM1O/O and Hpyloriinfection or smoking. CONCLUSION: Polymorphisms of the CYPIA1 and GSTM1 genes, Hpyloriinfection and smoking are related to susceptibility to stomach cancer. 展开更多
关键词 Stomach cancer CYPIA1 GSTM1 POLYMORPHISM
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