Analysis of the influencing factors and clinical related characteristics of pulmonary tuberculosis in patients with type 2 diabetes mellitus

BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cases,with approximately 4.5 million individuals affected by active tuberculosis.Notably,T2DM poses a significant risk factor for the development of tuberculosis,as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis(T2DMPTB),which has risen from 19.3%to 24.1%.It is evident that these two diseases are intricately interconnected and mutually reinforcing in nature.AIM To elucidate the clinical features of individuals diagnosed with both T2DM and tuberculosis(T2DM-PTB),as well as to investigate the potential risk factors associated with active tuberculosis in patients with T2DM.METHODS T2DM-PTB patients who visited our hospital between January 2020 and January 2023 were selected as the observation group,Simple DM patients presenting to our hospital in the same period were the control group,Controls and case groups were matched 1:2 according to the principle of the same sex,age difference(±3)years and disease duration difference(±5)years,patients were investigated for general demographic characteristics,diabetes-related characteristics,body immune status,lifestyle and behavioral habits,univariate and multivariate analysis of the data using conditional logistic regression,calculate the odds ratio(OR)values and 95%CI of OR values.RESULTS A total of 315 study subjects were included in this study,including 105 subjects in the observation group and 210 subjects in the control group.Comparison of the results of both anthropometric and biochemical measures showed that the constitution index,systolic blood pressure,diastolic blood pressure and lymphocyte count were significantly lower in the case group,while fasting blood glucose and high-density lipoprotein cholesterol levels were significantly higher than those in the control group.The results of univariate analysis showed that poor glucose control,hypoproteinemia,lymphopenia,TB contact history,high infection,smoking and alcohol consumption were positively associated with PTB in T2DM patients;married,history of hypertension,treatment of oral hypoglycemic drugs plus insulin,overweight,obesity and regular exercise were negatively associated with PTB in T2DM patients.Results of multivariate stepwise regression analysis found lymphopenia(OR=17.75,95%CI:3.40-92.74),smoking(OR=12.25,95%CI:2.53-59.37),history of TB contact(OR=6.56,95%CI:1.23-35.03)and poor glycemic control(OR=3.37,95%CI:1.11-10.25)was associated with an increased risk of developing PTB in patients with T2DM,While being overweight(OR=0.23,95%CI:0.08-0.72)and obesity(OR=0.11,95%CI:0.02-0.72)was associated with a reduced risk of developing PTB in patients with T2DM.CONCLUSION T2DM-PTB patients are prone to worse glycemic control,higher infection frequency,and a higher proportion of people smoking,drinking alcohol,and lack of exercise.Lymphopenia,smoking,history of TB exposure,poor glycemic control were independent risk factors for T2DM-PTB,and overweight and obesity were associated with reduced risk of concurrent PTB in patients with T2DM.

精子核蛋白成熟度与精液常规参数的相关性分析

目的探讨精子核蛋白成熟度与常规精液参数之间的相关性。方法随机选择371例精液标本,利用伟力彩色精子质量检测系统进行精液常规分析,采用Diff-Quick快速染色法和苯胺蓝染色法分别检测精子形态及精子核蛋白成熟度。依据核蛋白成熟度分组,比较精液常规参数的差异并分析核蛋白成熟度与精液常规参数间是否存在相关性。结果核蛋白成熟度<70%时,精子浓度、精子总数、前向运动精子比例及正常形态精子比例均低于核蛋白成熟度≥70%组,差异有统计学意义(P<0.05);核蛋白成熟度与精子浓度、精子总数、前向运动精子比例及正常形态比例精子呈正相关(P<0.05);受试者工作特征曲线(ROC)分析表明,精子浓度、精子总数、前向运动精子比例及正常精子形态可预测核蛋白成熟度,且精子总数预测的准确性最高。结论精子核蛋白成熟度与精子浓度、精子总数、前向运动精子比例及正常形态精子比例等常规精液参数具有相关性,常规精液参数可预测核蛋白成熟度。

胃底腺息肉的临床特征及其与结直肠肿瘤相关性的研究进展

胃底腺息肉(fundic gland polyps,FGPs)系胃底胃体黏膜形成的多发性广基息肉状隆起,是胃息肉最常见的类型,一般倾向于良性.有研究表明,FGPs患者发生结直肠肿瘤(腺瘤和癌)的风险较一般人群高,但也存在争议.本文旨在结合国内外研究现状,对FGPs及其与结直肠肿瘤之间的相关性予以综述.

Effect of lollipop sucking on the recovery of gastrointestinal function in children after congenital choledochal cyst excision: A randomized controlled trial

This study is aimed to evaluate the effect of lollipop sucking on the recovery of gastrointestinal function in children after congenital choledochal cyst excision.58 children who had undergone congenital choledochal cyst excision were randomly divided into two groups:the controlled group and the experimental group.Children in the experimental group were allowed to suck on strawberry lollipops for 20e30 min once every four hours beginning six hours after the operation.The recovery time of bowel sounds and anal defecation was recorded and compared between experimental and control groups.Compared with the controlled group the recovery times of bowel sounds(41.75±7.38 h vs.51.43±5.02;p<0.001)and anal defecation(64.32±14.69 h vs.79.17±14.91 h;p<0.001)were significantly shorter in the experimental group.Results of the present study indicate that Sucking of lollipops by children after choledochal cyst excision facilitates the recovery of bowel movement and relieves postoperative abdominal distension.

Effect of TACE combined with radiotherapy on the expression of serum tumor markers and malignant molecules in patients with primary large liver cancer

Objective:To investigate the effect of TACE combined with radiotherapy on the expression of serum tumor markers and malignant molecules in patients with primary large liver cancer.Methods:A total of 90 patients with primary large liver cancer who were treated in our hospital between September 2016 and September 2018 were retrospectively analyzed and divided into the control group(n=51)who received radiotherapy and the TACE group(n=39)who received TACE combined with radiotherapy.The expression levels of serum tumor markers,angiogenesis indexes and apoptosis molecules were compared between the two groups before and after treatment.Results:Before treatment,there were no statistically significant differences in the expression levels of serum tumor markers,angiogenesis indexes or apoptotic molecules between the two groups.After treatment,the serum levels of tumor markers AFP,AFu,CGT,CEA and CA19-9 in the TACE group were lower than those in the control group;the serum levels of angiogenesis indexes HGF,VEGF,MMP-9 and EGFR were lower than those in the control group;the serum levels of apoptosis molecules Bax,Caspase-4 and Caspase-10 were higher than those in the control group,while the levels of Bcl-2 and Survivin were lower than those in the control group.Conclusion:TACE on the basis of radiotherapy can further reduce the tumor malignancy in primary large liver cancer patients.

Effect of the adaptive intermittent ventilation before radical operation for lung cancer under one-lung ventilation on the non-ventilated lung tissue injury and apoptosis molecule protein expression

Objective: To study the effect of the adaptive intermittent ventilation before radical operation for lung cancer under one-lung ventilation on non-ventilated lung tissue injury and apoptosis molecule protein expression. Methods: A total of 288 patients who received radical operation for lung cancer in the hospital between February 2015 and January 2017 were divided into control group and observation group by random number table method, each with 144 cases. Control group received routine one-lung ventilation, and observation group received preoperative adaptive intermittent ventilation of non-ventilated lung tissue. The differences in the levels of inflammatory factors and oxidative stress indexes in serum as well as the apoptosis molecule protein expression in affected-side normal lung tissue were compared between the two groups of patients immediately after intubation and at two-lung ventilation (T0) as well as 10 min before operation ended and at one-lung ventilation (T1). Results: At T0, the differences in the levels of inflammatory factors and oxidative stress indexes in serum as well as the apoptosis molecule protein expression in affected-side normal lung tissue were not significantly significant between the two groups of patients;at T1, IL-1β, IL-8, TNF-α, MPO and MDA levels in serum as well as Bax, caspase-2 and caspase-3 protein expression in normal lung tissue of observation group were lower than those of control group while SOD level in serum and Bcl-2 protein expression in normal lung tissue were higher than those of control group. Conclusion: Adaptive intermittent ventilation before radical operation for lung cancer under one-lung ventilation can effectively reduce the non-ventilated lung tissue injury and inhibit the apoptosis of normal lung cells.

Osa-miR1873 fine-tunes rice immunity against Magnaporthe oryzae and yield traits

MicroRNAs(miRNAs)are known to fine-tune growth,development,and stress-induced responses.Osa-miR1873 is a rice-specific miRNA targeting LOC_Os05g01790.Here,we show that Osa-miR1873 fine-tunes rice immunity against Magnaporthe oryzae and yield traits via LOC_Os05g01790.Osa-miR1873 was significantly upregulated in a susceptible accession but downregulated in a resistance accession at 24 h post-inoculation(hpi)of M.oryzae.Overexpressing Osa-miR1873 enhanced susceptibility to M.oryzae and compromised induction of defense responses.In contrast,blocking Osa-miR1873 through target mimicry compromised susceptibility to M.oryzae and enhanced induction of defense responses.Altered expression of Osa-miR1873 also resulted in some defects in yield traits,including grain numbers and seed setting rate.Moreover,overexpression of the target gene LOC_Os05g01790 increased rice blast disease resistance but severely penalized growth and yield.Taken together,we demonstrate that Osa-miR1873 fine-tunes the rice immunity-growth trade-off via LOC_Os05g01790,and blocking Osa-miR1873 could improve blast disease resistance without significant yield penalty.Thus,the Osa-miR1873-LOC_Os05g01790 regulatory module is valuable in balancing yield traits and blast resistance.

Hot deformation behavior and processing parameter optimization of BT25y alloy with an initial equiaxed microstructure using processing map

The high-temperature plastic deformation behavior of BT25y alloy with an initial equiaxed microstructure was investigated by hot compression tests. Processing maps were established to evaluate the power dissipation efficiency （η） and identify the flow instability regions. When the strain reaches steady state, the optimum processing window is distributed in the area covering most of the studied deformation temperatures and strain rates of 1 × 10-2 to 1× 10-1 s-1. True strain has great effects on the power dissipation efficiency under the condition of 880 ℃/1× 10-3 s-1, but the efficiency values remain approximately constant （η= 0.40） at conditions of 900-940 ℃/1× 10-2 to 1 × 10-1 S-1 and 980-1000 ℃/ 1× 10-1 s- 1. Besides, the instability regions are distributed in high strain rate areas no matter how many of the strains. Based on the processing map and microstructural observa- tion, it can be concluded that the deformation mechanisms related to Region I with small strain rate and lower temper- ature in α＋β phase field, Region II with medium strain rate and higher temperature inα＋β phase field, Region III with medium strain rate and high temperature in βphase field are superplasticity and strain-induced transformation, dynamicrecrystallization （DRX） and phase transformation, β phase dynamic recovery and local DRX, respectively.