In reptiles, habitat selection is the process whereby suitable habitat is selected that optimizes physiological functions and behavioral performance. Here, we used the brown forest skink（Sphenomorphus indicus） as a ...In reptiles, habitat selection is the process whereby suitable habitat is selected that optimizes physiological functions and behavioral performance. Here, we used the brown forest skink（Sphenomorphus indicus） as a model animal and examined whether the frequency of active individuals, environmental temperature, illumination of activity area, and habitat type vary with different age classes. We surveyed the number of active individuals and measured environmental variables at Baiyunshan Mountain in Lishui, Zhejiang, China. We found no difference in the activity frequency of adult and juvenile S. indicus; the activity pattern of active individuals was bimodal. The mean environmental temperature selected by adults was higher than that selected by juveniles. The environmental temperature of active areas measured at 0900-1000 h and 1100-1200 h was higher than at 1400-1500h; illumination of the active area at 1000-1200 h was also higher than at 1400h-1600 h. The number of active individuals, the environmental temperature and illumination of activity areas showed pairwise positive correlation. There was a difference in habitat type between juveniles and adults whereby juveniles prefer rock habitats. We predict that active S. indicus select optimal habitats with different environmental temperatures and types to reach the physiological needs particular to their age classes.展开更多
The development of functional nanocarriers with multifunctional ability and expected degradability is of great significance for efficient drug delivery on tumor therapy.The release of non-specific drugs and serious si...The development of functional nanocarriers with multifunctional ability and expected degradability is of great significance for efficient drug delivery on tumor therapy.The release of non-specific drugs and serious side effects severely limit their therapeutic effectiveness,although chemotherapy has been far and widely used in clinical practice[1-4].In the past few decades,nanosized drug carriers integrated with multi-responsive properties have emerged as promising candidates for anticancer treatment due to their long circulation in the bloodstream,high drug loading capacity,and“passive”targeting capability on account of the enhanced permeability and retention(EPR)effect[5-8].展开更多
To the Editor:Coronary heart disease(CHD)and depression are common in patients worldwide and have a high comorbidity rate.Researches on depression have shown that it has been linked with long-term risk for CHD.[1]The ...To the Editor:Coronary heart disease(CHD)and depression are common in patients worldwide and have a high comorbidity rate.Researches on depression have shown that it has been linked with long-term risk for CHD.[1]The incidence and mortality of depression with CHD were higher,and the prognosis was worse.[2]The association between CHD and depression is well established and is suggested to be bidirectional.[3]Therefore,to provide possible conditions for the study of depression with CHD in the future,establishing a reliable animal model of depression with CHD is necessary.Chronic unpredictable mild stress(CUMS)is the most widely used to establish an animal model of depression for the past few years.Feeding a high-fat diet(HFD)to rats is a widely used method for establishing a model for atherosclerosis and CHD.Research reported that female cynomolgus monkeys that were housed in single cages and consumed an atherogenic diet could develop depression combined with CHD model.[4]Another paper reported that CUMS combined with HFD in rats was similar to the clinical manifestation of vascular depression in humans.[5]The former demonstrated that housing in single cages and feeding an atherogenic diet in monkeys could establish a depression combined with CHD model,the latter demonstrated that CUMS combined with HFD in rats was similar to vascular depression.It remains unclear whether CUMS combined with HFD in rats could establish a complex rat model of depression with CHD.Consequently,the aim of this study was to explore whether CUMS combined with HFD in rats could establish a representative,reliable rat model of depression with CHD and to provide possible conditions for an in-depth study of depression with CHD.展开更多
基金supported by the Open Research Fund program of Laboratory of Lishui University(2014-26-10)the Scientific Research Foundation of Ph.D.in Lishui University(QD1301)+1 种基金the Science and Technology Planning Project of Lishui(20110426)the Project of Summer Work for Undergraduates in Lishui University(2014-245-23)
文摘In reptiles, habitat selection is the process whereby suitable habitat is selected that optimizes physiological functions and behavioral performance. Here, we used the brown forest skink（Sphenomorphus indicus） as a model animal and examined whether the frequency of active individuals, environmental temperature, illumination of activity area, and habitat type vary with different age classes. We surveyed the number of active individuals and measured environmental variables at Baiyunshan Mountain in Lishui, Zhejiang, China. We found no difference in the activity frequency of adult and juvenile S. indicus; the activity pattern of active individuals was bimodal. The mean environmental temperature selected by adults was higher than that selected by juveniles. The environmental temperature of active areas measured at 0900-1000 h and 1100-1200 h was higher than at 1400-1500h; illumination of the active area at 1000-1200 h was also higher than at 1400h-1600 h. The number of active individuals, the environmental temperature and illumination of activity areas showed pairwise positive correlation. There was a difference in habitat type between juveniles and adults whereby juveniles prefer rock habitats. We predict that active S. indicus select optimal habitats with different environmental temperatures and types to reach the physiological needs particular to their age classes.
文摘The development of functional nanocarriers with multifunctional ability and expected degradability is of great significance for efficient drug delivery on tumor therapy.The release of non-specific drugs and serious side effects severely limit their therapeutic effectiveness,although chemotherapy has been far and widely used in clinical practice[1-4].In the past few decades,nanosized drug carriers integrated with multi-responsive properties have emerged as promising candidates for anticancer treatment due to their long circulation in the bloodstream,high drug loading capacity,and“passive”targeting capability on account of the enhanced permeability and retention(EPR)effect[5-8].
基金The study was approved by the grants from the National Natural Science Foundation of China(No.81560730)the Training Project for Young and Middle-aged Chinese Medicine Leaders in Yunnan Province.
文摘To the Editor:Coronary heart disease(CHD)and depression are common in patients worldwide and have a high comorbidity rate.Researches on depression have shown that it has been linked with long-term risk for CHD.[1]The incidence and mortality of depression with CHD were higher,and the prognosis was worse.[2]The association between CHD and depression is well established and is suggested to be bidirectional.[3]Therefore,to provide possible conditions for the study of depression with CHD in the future,establishing a reliable animal model of depression with CHD is necessary.Chronic unpredictable mild stress(CUMS)is the most widely used to establish an animal model of depression for the past few years.Feeding a high-fat diet(HFD)to rats is a widely used method for establishing a model for atherosclerosis and CHD.Research reported that female cynomolgus monkeys that were housed in single cages and consumed an atherogenic diet could develop depression combined with CHD model.[4]Another paper reported that CUMS combined with HFD in rats was similar to the clinical manifestation of vascular depression in humans.[5]The former demonstrated that housing in single cages and feeding an atherogenic diet in monkeys could establish a depression combined with CHD model,the latter demonstrated that CUMS combined with HFD in rats was similar to vascular depression.It remains unclear whether CUMS combined with HFD in rats could establish a complex rat model of depression with CHD.Consequently,the aim of this study was to explore whether CUMS combined with HFD in rats could establish a representative,reliable rat model of depression with CHD and to provide possible conditions for an in-depth study of depression with CHD.
