BACKGROUND Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal inflammation.Oral probiotics are one of the postoperative treatments for rapid rehabilitation.However,there is a lack...BACKGROUND Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal inflammation.Oral probiotics are one of the postoperative treatments for rapid rehabilitation.However,there is a lack of prospective studies on this topic after appendectomy.AIM To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following appendectomy.METHODS This was a prospective,randomized trial.A total of 60 emergency patients were randomly divided into a control group(n=30)and a probiotic group(n=30).Patients in the control group started to drink some water the first day after surgery,and those in the probiotic group were given water supplemented with Bacillus licheniformis capsules for 5 consecutive days postsurgery.The indices of inflammation and postoperative conditions were recorded,and the data were analyzed with RStudio 4.3.2 software.RESULTS A total of 60 participants were included.Compared with those in the control group,the C-reactive protein(CRP),interleukin 6 and procalcitonin(PCT)levels were significantly lower in the probiotic group at 2 d after surgery(P=2.224e-05,P=0.037,and P=0.002,respectively,all P<0.05).This trend persisted at day 5 post-surgery,with CRP and PCT levels remaining significantly lower in the probiotic group(P=0.001 and P=0.043,both P<0.05).Furthermore,probiotics0.028,both P<0.05).CONCLUSION Postoperative oral administration of probiotics may modulate the gut microbiota,benefit the recovery of the early inflammatory response,and subsequently enhance recovery after appendectomy.展开更多
To improve the strength-toughness of traditional U-rib（ TUR） and solve the problem of insufficient penetration between TUR and deckplate,a new local thickened U-rib（ LTUR） has been proposed to improve the fatigue ...To improve the strength-toughness of traditional U-rib（ TUR） and solve the problem of insufficient penetration between TUR and deckplate,a new local thickened U-rib（ LTUR） has been proposed to improve the fatigue resistance of the weld joint under the premise of not increasing thickness and strength of the TUR material. And a hot /warm roll-forming process（ RFP） adopting partially induction heating to 700- 1 000℃ was carried out to fabricate LTUR. The deformation behaviors in the forming process and microstructure of LTUR have been investigated.Mechanical properties and fracture mechanism of the LTUR after hot / warm RFP have been systematically discussed. Moreover,the results are compared with those obtained in cold RFP. Mechanical properties of the LTUR deformed above the critical transformation temperature（ A_（c3）） show high performance characteristics with marked fatigue resistance and superior toughness. Upon increasing the heating temperature from 700 to 900 ℃,the initial coarse ferrite-pearlite structure transform into equiaxed ultrafine ferrite（ 1- 3 μm） and precipitates such as（ Nb,Ti）（ C,N） are uniformly distributed in the matrix. The average dislocation density of the specimens after hot rollforming at heating temperature of 900 ℃ decreases dramatically compared with those of the specimens subjected to the cold RFP. Furthermore,a typical characteristic of ductile fracture mechanism and the high impact energy are more convinced that the specimens deformed above 900 ℃ have obtained an optimal combination of strength and toughness.展开更多
文摘BACKGROUND Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal inflammation.Oral probiotics are one of the postoperative treatments for rapid rehabilitation.However,there is a lack of prospective studies on this topic after appendectomy.AIM To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following appendectomy.METHODS This was a prospective,randomized trial.A total of 60 emergency patients were randomly divided into a control group(n=30)and a probiotic group(n=30).Patients in the control group started to drink some water the first day after surgery,and those in the probiotic group were given water supplemented with Bacillus licheniformis capsules for 5 consecutive days postsurgery.The indices of inflammation and postoperative conditions were recorded,and the data were analyzed with RStudio 4.3.2 software.RESULTS A total of 60 participants were included.Compared with those in the control group,the C-reactive protein(CRP),interleukin 6 and procalcitonin(PCT)levels were significantly lower in the probiotic group at 2 d after surgery(P=2.224e-05,P=0.037,and P=0.002,respectively,all P<0.05).This trend persisted at day 5 post-surgery,with CRP and PCT levels remaining significantly lower in the probiotic group(P=0.001 and P=0.043,both P<0.05).Furthermore,probiotics0.028,both P<0.05).CONCLUSION Postoperative oral administration of probiotics may modulate the gut microbiota,benefit the recovery of the early inflammatory response,and subsequently enhance recovery after appendectomy.
基金Project(51674230) supported by the National Natural Science Foundation of ChinaProject(2018YFC1900505) supported by the National Key R&D Program of China
文摘To improve the strength-toughness of traditional U-rib（ TUR） and solve the problem of insufficient penetration between TUR and deckplate,a new local thickened U-rib（ LTUR） has been proposed to improve the fatigue resistance of the weld joint under the premise of not increasing thickness and strength of the TUR material. And a hot /warm roll-forming process（ RFP） adopting partially induction heating to 700- 1 000℃ was carried out to fabricate LTUR. The deformation behaviors in the forming process and microstructure of LTUR have been investigated.Mechanical properties and fracture mechanism of the LTUR after hot / warm RFP have been systematically discussed. Moreover,the results are compared with those obtained in cold RFP. Mechanical properties of the LTUR deformed above the critical transformation temperature（ A_（c3）） show high performance characteristics with marked fatigue resistance and superior toughness. Upon increasing the heating temperature from 700 to 900 ℃,the initial coarse ferrite-pearlite structure transform into equiaxed ultrafine ferrite（ 1- 3 μm） and precipitates such as（ Nb,Ti）（ C,N） are uniformly distributed in the matrix. The average dislocation density of the specimens after hot rollforming at heating temperature of 900 ℃ decreases dramatically compared with those of the specimens subjected to the cold RFP. Furthermore,a typical characteristic of ductile fracture mechanism and the high impact energy are more convinced that the specimens deformed above 900 ℃ have obtained an optimal combination of strength and toughness.
