AIM:To analyze changes in amplitude of low-frequency fluctuations(ALFFs)and default mode network(DMN)connectivity in the brain,using resting-state functional magnetic resonance imaging(rs-fMRI),in high myopia(HM)patie...AIM:To analyze changes in amplitude of low-frequency fluctuations(ALFFs)and default mode network(DMN)connectivity in the brain,using resting-state functional magnetic resonance imaging(rs-fMRI),in high myopia(HM)patients.METHODS:Eleven patients with HM(HM group)and 15 age-and sex-matched non-HM controls(non-HM group)were recruited.ALFFs were calculated and compared between HM group and non-HM group.Independent component analysis(ICA)was conducted to identify DMN,and comparisons between DMNs of two groups were performed.Region-of-interest(ROI)-based analysis was performed to explore functional connectivity(FC)between DMN regions.RESULTS:Significantly increased ALFFs in left inferior temporal gyrus(ITG),bilateral rectus gyrus(REC),bilateral middle temporal gyrus(MTG),left superior temporal gyrus(STG),and left angular gyrus(ANG)were detected in HM group compared with non-HM group(all P<0.01).HM group showed increased FC in the posterior cingulate gyrus(PCC)/precuneus(preCUN)and decreased FC in the left medial prefrontal cortex(mPFG)within DMN compared with nonHM group(all P<0.01).Compared with non-HM group,HM group showed higher FC between mPFG and bilateral middle frontal gyrus(MFG),ANG,and MTG(all P<0.01).In addition,HM patients showed higher FC between PCC/(preCUN)and the right cerebellum,superior frontal gyrus(SFG),left pre CUN,superior frontal gyrus(SFG),and medial orbital of the superior frontal gyrus(ORB supmed;all P<0.01).CONCLUSION:HM patients show different ALFFs and DMNs compared with non-HM subjects,which may imply the cognitive alterations related to HM.展开更多
A line laser with high power as the background light source for the design of a new photoelectric detection target is proposed in this paper, aiming to improve the detection ability of the traditional photoelectric de...A line laser with high power as the background light source for the design of a new photoelectric detection target is proposed in this paper, aiming to improve the detection ability of the traditional photoelectric detection target under low background illumination. The laser emitted pulse waveform function and the laser echo pulse response function were used to establish the mathematical model of the reflected echo power of projectile in the detection area and derive the calculation function of minimum detectable echo power in the line laser detection screen, according to information of the line laser emitted power, incident angle of projectile, duration time and detection distance of projectile passing through the line laser detection screen. Calculations and experimental results showed that the design method of line laser detection screen and calculation model of laser echo power are reasonable, and the detection ability of line laser detection screen is obviously higher than that of traditional photoelectric detection screen, especially in low background illumination;at the same time, the designed line laser detection screen was used to combine a six line laser detection screen intersection test system, based on live ammunition for shooting. The test system is stable and able to obtain the dynamic parameters of the flying projectile, verifying that the design of the line laser detection screen in new photoelectric detection target can be suitable for shooting range test applications.展开更多
A novel bandpass filter(BPF)based on spoof surface plasmon polaritons(SSPPs)using a compact folded slotline structure is proposed and experimentally demonstrated.The proposed novel SSPPs structure compared with a conv...A novel bandpass filter(BPF)based on spoof surface plasmon polaritons(SSPPs)using a compact folded slotline structure is proposed and experimentally demonstrated.The proposed novel SSPPs structure compared with a conventional plasmonic waveguide with slot line SSPPs unit structure at the same size,the considerable advantages in much lower asymptotic frequency with tight field confinement,which enable the proposed filter to be more miniaturization.A high-efficient mode conversion structure is designed to transition from TE-mode to SSPPs-mode by gradient slotline lengths.The low-frequency stop-band can be committed with microstrip to slotline evolution on both sides of the dielectric,while the high-frequency cutoff band is realized by the proposed SSPPs structure.The influence of dispersion relation,electric field distribution,surface current,and structural parameters on the transmission characteristics of the proposed BPF are analyzed by finite difference time domain(FDTD).To validate the design concept,the prototype of the miniaturized SSPPs BPF has been manufactured and measured.The experimental results show high performance of the fabricated sample,in which the working in a range of 0.9 GHz-5.2 GHz with the relative bandwidth is 142%,the insertion loss less than 0.5 dB,the reflection coefficient less than-10 dB,and the group delay is less than one ns.This works provides a mirror for realizing the miniaturization of waveguides,and the application and development of high-confinement SSPPs functional devices in the microwave and THz regimes.展开更多
An ultra-wideband bandpass filter(BPF)with a wide out-of-band rejection based on a surface plasmonic waveguide(SPW)slotline with ring grooves is designed and analyzed.A paired microstrip-to-slotline transition is desi...An ultra-wideband bandpass filter(BPF)with a wide out-of-band rejection based on a surface plasmonic waveguide(SPW)slotline with ring grooves is designed and analyzed.A paired microstrip-to-slotline transition is designed for quasiTEM to TM mode conversion by using a microstrip line with a circular pad and the slotline with the same circular slot.The mode conversion between the TM and the surface plasmon polariton(SPP)mode is realized by using a gradient slotline with ring grooves and an impedance matching technique.The upper cut-off frequencies of the passband can be adjusted by using these proposed SPP units,while the lower frequencies of the passband are created by using the microstrip-toslotline transitions to give an ultra-wideband BPF.The dispersion curves of SPP units,electric field distribution,and the transmission spectra of the proposed ultra-wideband bandpass filter are all calculated and analyzed by the finite-difference time-domain(FDTD)method.The simulated results show that the presented filter has good performance including a wide3-dB bandwidth of 149%from 0.57 GHz to 3.93 GHz,an extremely wide 40-dB upper-band rejection from 4.2 GHz to18.5 GHz,and low loss and high selectivity in the passband.To prove the design validity,a prototype of the BPF has been manufactured and measured,showing a reasonable agreement with simulation results.The unique features of the proposed BPF may make it applicable for integrated circuit and plasmonic devices in microwave or THz frequency ranges.展开更多
Understanding the abundance and distribution characteristics of FeO on the surface of the Moon is important for investigating its evolution. The current high resolution maps of the global FeO abundance are mostly prod...Understanding the abundance and distribution characteristics of FeO on the surface of the Moon is important for investigating its evolution. The current high resolution maps of the global FeO abundance are mostly produced with visible and near infrared reflectance spectra. The Christiansen Feature (CF) in mid-infrared has strong sensitivity to lunar minerals and correlates to major elements composing minerals. This paper investigates the possibility of mapping global FeO abundance using the CF values from the Diviner Lunar Radiometer Experiment aboard the Lunar Reconnaissance Orbiter (LRO) mission. A high correlation between the CF values and FeO abundances from the Apollo samples was found. Based on this high correlation, a new global map (±60°) of FeO was produced using the CF map. The results show that the global FeO average is 8.2 wt.%, the highland average is 4.7 wt.%, the global modal abundance is 5.4 wt.% and the lunar mare mode is 15.7 wt.%. These results are close to those derived from data provided by Clementine, the Lunar Prospector Gamma Ray Spectrometer (LP-GRS) and the Chang'e-1 Interference Imaging Spectrometer (IIM), demonstrating the feasibility of estimating FeO abundance based on the Diviner CF data. The near global FeO abundance map shows an enrichment of lunar major elements.展开更多
Objective: To study the effect of Thymosin Injection combined with entecavir therapy on the viral load, liver fibrosis and immune response of patients with compensated liver cirrhosis. Methods: Patients who were diagn...Objective: To study the effect of Thymosin Injection combined with entecavir therapy on the viral load, liver fibrosis and immune response of patients with compensated liver cirrhosis. Methods: Patients who were diagnosed with chronic hepatitis b complicated by compensated liver cirrhosis in our hospital between March 2015 and January 2017 were selected and randomly divided into two groups, observation group received Thymosin Injection combined with entecavir therapy, and control group received entecavir therapy. The viral load, liver function injury indexes, liver fibrosis indexes, immune cytokines and immune cell apoptosis molecules were measured 24 weeks after treatment. Results: 24 weeks after treatment, HBV-DNA copy number in peripheral blood as well as ALT, AST, TBIL, HA, PC-III, LN, C-IV, IL-4, IL-10, TGF-β1, IL-17 and IL-22 levels in serum of observation group was significantly lower than those of control group, and peripheral blood FAS, CYCS, CASP8, CASP9 and CASP3 mRNA expression were significantly lower than those of control group. Conclusion:Thymosin Injection combined with entecavir therapy can reduce viral load, improve liver function, inhibit liver fibrosis and regulate immune function in patients with compensated liver cirrhosis.展开更多
The objective of this study was to develop, as well as validate the strongly coupled method (two-way fluid structural interaction (FSI)) used to simulate the transient FSI response of the vertical axis tidal turbine (...The objective of this study was to develop, as well as validate the strongly coupled method (two-way fluid structural interaction (FSI)) used to simulate the transient FSI response of the vertical axis tidal turbine (VATT) rotor, subjected to spatially varying inflow. Moreover, this study examined strategies on improving techniques used for mesh deformation that account for large displacement or deformation calculations. The blade's deformation for each new time step is considered in transient two-way FSI analysis, to make the design more reliable. Usually this is not considered in routine one-way FSI simulations. A rotor with four blades and 4-m diameter was modeled and numerically analyzed. We observed that two-way FSI, utilizing the strongly coupled method, was impossible for a complex model; and thereby using ANSYS-CFX and ANSYS-MECHANICAL in work bench, as given in ANSYS-WORKBENCH, helped case examples 22 and 23, by giving an error when the solution was run. To make the method possible and reduce the computational power, a novel technique was used to transfer the file in ANSYS-APDL to obtain the solution and results. Consequently, the results indicating a two-way transient FSI analysis is a time- and resource-consuming job, but with our proposed technique we can reduce the computational time. The ANSYS STRUCTURAL results also uncover that stresses and deformations have higher values for two-way FSI as compared to one-way FSI. Similarly, fluid flow CFX results for two-way FSI are closer to experimental results as compared to one-way simulation results. Additionally, this study shows that, using the proposed method we can perform coupled simulation with simple multi-node PCs (core i5).展开更多
The last few decades have witnessed an increasing emphasis on the development of strain-based ap- proach for predicting the creep life or damage of components operating at elevated temperatures. Creep ductility, as a ...The last few decades have witnessed an increasing emphasis on the development of strain-based ap- proach for predicting the creep life or damage of components operating at elevated temperatures. Creep ductility, as a key parameter in this approach, may vary with a number of factors including strain rate, state of stress, operating temperature, material microstructure, etc. The present paper, however, is focused on reviewing the state-of-the-art understanding of the effects of stress level and stress state on the creep ductility. Mechanisms involving the void growth and coalescence are presented to describe the role of stress level in the variation of uniaxial creep ductility. The prediction capacity of existing empirical duc- tility models is also assessed in light of uniaxial test data. On the other hand, a vast body of multiaxial creep test data, collected from open literature, is utilized to examine the influence of the state of stress on the creep ductility. Then, a variety of multiaxial ductility factor models are introduced and evaluated with the available experimental data. Finally, a brief discussion on the dependence of creep ductility on the stress triaxiality and Lode parameter, predicted by numerical methods, is provided.展开更多
基金Supported by the National Natural Science Foundation of China(No.81870685)Beijing Natural Science Foundation(No.7172173)Key Laboratory of Myopia,Ministry of Health(Fudan University)(No.EENTM-15-01)。
文摘AIM:To analyze changes in amplitude of low-frequency fluctuations(ALFFs)and default mode network(DMN)connectivity in the brain,using resting-state functional magnetic resonance imaging(rs-fMRI),in high myopia(HM)patients.METHODS:Eleven patients with HM(HM group)and 15 age-and sex-matched non-HM controls(non-HM group)were recruited.ALFFs were calculated and compared between HM group and non-HM group.Independent component analysis(ICA)was conducted to identify DMN,and comparisons between DMNs of two groups were performed.Region-of-interest(ROI)-based analysis was performed to explore functional connectivity(FC)between DMN regions.RESULTS:Significantly increased ALFFs in left inferior temporal gyrus(ITG),bilateral rectus gyrus(REC),bilateral middle temporal gyrus(MTG),left superior temporal gyrus(STG),and left angular gyrus(ANG)were detected in HM group compared with non-HM group(all P<0.01).HM group showed increased FC in the posterior cingulate gyrus(PCC)/precuneus(preCUN)and decreased FC in the left medial prefrontal cortex(mPFG)within DMN compared with nonHM group(all P<0.01).Compared with non-HM group,HM group showed higher FC between mPFG and bilateral middle frontal gyrus(MFG),ANG,and MTG(all P<0.01).In addition,HM patients showed higher FC between PCC/(preCUN)and the right cerebellum,superior frontal gyrus(SFG),left pre CUN,superior frontal gyrus(SFG),and medial orbital of the superior frontal gyrus(ORB supmed;all P<0.01).CONCLUSION:HM patients show different ALFFs and DMNs compared with non-HM subjects,which may imply the cognitive alterations related to HM.
基金This work has been supported by Project of the National Natural Science Foundation of China(No.62073256,61773305)in part by the Key Science and Technology Program of Shaanxi Province(No.2020GY-125)Xi’an Science and Technology Innovation Talent Service Enterprise Project(No.2020KJRC0041).
文摘A line laser with high power as the background light source for the design of a new photoelectric detection target is proposed in this paper, aiming to improve the detection ability of the traditional photoelectric detection target under low background illumination. The laser emitted pulse waveform function and the laser echo pulse response function were used to establish the mathematical model of the reflected echo power of projectile in the detection area and derive the calculation function of minimum detectable echo power in the line laser detection screen, according to information of the line laser emitted power, incident angle of projectile, duration time and detection distance of projectile passing through the line laser detection screen. Calculations and experimental results showed that the design method of line laser detection screen and calculation model of laser echo power are reasonable, and the detection ability of line laser detection screen is obviously higher than that of traditional photoelectric detection screen, especially in low background illumination;at the same time, the designed line laser detection screen was used to combine a six line laser detection screen intersection test system, based on live ammunition for shooting. The test system is stable and able to obtain the dynamic parameters of the flying projectile, verifying that the design of the line laser detection screen in new photoelectric detection target can be suitable for shooting range test applications.
基金the National Natural Science Foundation of China(Grant Nos.62071221 and 62071442)the Equipment Advance Research Foundation of China(Grant No.80909010302)the Key Laboratory of Radar Imaging and Microwave Photonics(Nanjing University of Aeronautics and Astronautics),Ministry of Education of China(Grant No.NJ20210006).
文摘A novel bandpass filter(BPF)based on spoof surface plasmon polaritons(SSPPs)using a compact folded slotline structure is proposed and experimentally demonstrated.The proposed novel SSPPs structure compared with a conventional plasmonic waveguide with slot line SSPPs unit structure at the same size,the considerable advantages in much lower asymptotic frequency with tight field confinement,which enable the proposed filter to be more miniaturization.A high-efficient mode conversion structure is designed to transition from TE-mode to SSPPs-mode by gradient slotline lengths.The low-frequency stop-band can be committed with microstrip to slotline evolution on both sides of the dielectric,while the high-frequency cutoff band is realized by the proposed SSPPs structure.The influence of dispersion relation,electric field distribution,surface current,and structural parameters on the transmission characteristics of the proposed BPF are analyzed by finite difference time domain(FDTD).To validate the design concept,the prototype of the miniaturized SSPPs BPF has been manufactured and measured.The experimental results show high performance of the fabricated sample,in which the working in a range of 0.9 GHz-5.2 GHz with the relative bandwidth is 142%,the insertion loss less than 0.5 dB,the reflection coefficient less than-10 dB,and the group delay is less than one ns.This works provides a mirror for realizing the miniaturization of waveguides,and the application and development of high-confinement SSPPs functional devices in the microwave and THz regimes.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.U2141232,62071221,and 62071442)the Aeronautical Science Foundation of China(Grant No.2019ZA037001)。
文摘An ultra-wideband bandpass filter(BPF)with a wide out-of-band rejection based on a surface plasmonic waveguide(SPW)slotline with ring grooves is designed and analyzed.A paired microstrip-to-slotline transition is designed for quasiTEM to TM mode conversion by using a microstrip line with a circular pad and the slotline with the same circular slot.The mode conversion between the TM and the surface plasmon polariton(SPP)mode is realized by using a gradient slotline with ring grooves and an impedance matching technique.The upper cut-off frequencies of the passband can be adjusted by using these proposed SPP units,while the lower frequencies of the passband are created by using the microstrip-toslotline transitions to give an ultra-wideband BPF.The dispersion curves of SPP units,electric field distribution,and the transmission spectra of the proposed ultra-wideband bandpass filter are all calculated and analyzed by the finite-difference time-domain(FDTD)method.The simulated results show that the presented filter has good performance including a wide3-dB bandwidth of 149%from 0.57 GHz to 3.93 GHz,an extremely wide 40-dB upper-band rejection from 4.2 GHz to18.5 GHz,and low loss and high selectivity in the passband.To prove the design validity,a prototype of the BPF has been manufactured and measured,showing a reasonable agreement with simulation results.The unique features of the proposed BPF may make it applicable for integrated circuit and plasmonic devices in microwave or THz frequency ranges.
基金supported by the National Natural Science Foundation of China(41172296 and 41422110)the Science and Technology Development Fund of Macao(048/2012/A2)the Key Research Program of the Chinese Academy of Sciences(KGZD-EW-603)
文摘Understanding the abundance and distribution characteristics of FeO on the surface of the Moon is important for investigating its evolution. The current high resolution maps of the global FeO abundance are mostly produced with visible and near infrared reflectance spectra. The Christiansen Feature (CF) in mid-infrared has strong sensitivity to lunar minerals and correlates to major elements composing minerals. This paper investigates the possibility of mapping global FeO abundance using the CF values from the Diviner Lunar Radiometer Experiment aboard the Lunar Reconnaissance Orbiter (LRO) mission. A high correlation between the CF values and FeO abundances from the Apollo samples was found. Based on this high correlation, a new global map (±60°) of FeO was produced using the CF map. The results show that the global FeO average is 8.2 wt.%, the highland average is 4.7 wt.%, the global modal abundance is 5.4 wt.% and the lunar mare mode is 15.7 wt.%. These results are close to those derived from data provided by Clementine, the Lunar Prospector Gamma Ray Spectrometer (LP-GRS) and the Chang'e-1 Interference Imaging Spectrometer (IIM), demonstrating the feasibility of estimating FeO abundance based on the Diviner CF data. The near global FeO abundance map shows an enrichment of lunar major elements.
文摘Objective: To study the effect of Thymosin Injection combined with entecavir therapy on the viral load, liver fibrosis and immune response of patients with compensated liver cirrhosis. Methods: Patients who were diagnosed with chronic hepatitis b complicated by compensated liver cirrhosis in our hospital between March 2015 and January 2017 were selected and randomly divided into two groups, observation group received Thymosin Injection combined with entecavir therapy, and control group received entecavir therapy. The viral load, liver function injury indexes, liver fibrosis indexes, immune cytokines and immune cell apoptosis molecules were measured 24 weeks after treatment. Results: 24 weeks after treatment, HBV-DNA copy number in peripheral blood as well as ALT, AST, TBIL, HA, PC-III, LN, C-IV, IL-4, IL-10, TGF-β1, IL-17 and IL-22 levels in serum of observation group was significantly lower than those of control group, and peripheral blood FAS, CYCS, CASP8, CASP9 and CASP3 mRNA expression were significantly lower than those of control group. Conclusion:Thymosin Injection combined with entecavir therapy can reduce viral load, improve liver function, inhibit liver fibrosis and regulate immune function in patients with compensated liver cirrhosis.
基金supported by the National Natural Science Foundation of China (Nos. 51209060 and 51106034)the ‘111’ Project Foundation from Ministry of Education and State Administration of Foreign Experts Affairs (No. B07019), Chinathe National Special Foundation for Ocean Energy (No. GHME2010CY01)
文摘The objective of this study was to develop, as well as validate the strongly coupled method (two-way fluid structural interaction (FSI)) used to simulate the transient FSI response of the vertical axis tidal turbine (VATT) rotor, subjected to spatially varying inflow. Moreover, this study examined strategies on improving techniques used for mesh deformation that account for large displacement or deformation calculations. The blade's deformation for each new time step is considered in transient two-way FSI analysis, to make the design more reliable. Usually this is not considered in routine one-way FSI simulations. A rotor with four blades and 4-m diameter was modeled and numerically analyzed. We observed that two-way FSI, utilizing the strongly coupled method, was impossible for a complex model; and thereby using ANSYS-CFX and ANSYS-MECHANICAL in work bench, as given in ANSYS-WORKBENCH, helped case examples 22 and 23, by giving an error when the solution was run. To make the method possible and reduce the computational power, a novel technique was used to transfer the file in ANSYS-APDL to obtain the solution and results. Consequently, the results indicating a two-way transient FSI analysis is a time- and resource-consuming job, but with our proposed technique we can reduce the computational time. The ANSYS STRUCTURAL results also uncover that stresses and deformations have higher values for two-way FSI as compared to one-way FSI. Similarly, fluid flow CFX results for two-way FSI are closer to experimental results as compared to one-way simulation results. Additionally, this study shows that, using the proposed method we can perform coupled simulation with simple multi-node PCs (core i5).
基金supported by the National Natural Science Foundation of China (Grant Nos. 11472105 and 51505149)the "111 project"The first author wishes to thank the financial support provided by Shanghai Sailing Program (Grant No. 15YF1402900)
文摘The last few decades have witnessed an increasing emphasis on the development of strain-based ap- proach for predicting the creep life or damage of components operating at elevated temperatures. Creep ductility, as a key parameter in this approach, may vary with a number of factors including strain rate, state of stress, operating temperature, material microstructure, etc. The present paper, however, is focused on reviewing the state-of-the-art understanding of the effects of stress level and stress state on the creep ductility. Mechanisms involving the void growth and coalescence are presented to describe the role of stress level in the variation of uniaxial creep ductility. The prediction capacity of existing empirical duc- tility models is also assessed in light of uniaxial test data. On the other hand, a vast body of multiaxial creep test data, collected from open literature, is utilized to examine the influence of the state of stress on the creep ductility. Then, a variety of multiaxial ductility factor models are introduced and evaluated with the available experimental data. Finally, a brief discussion on the dependence of creep ductility on the stress triaxiality and Lode parameter, predicted by numerical methods, is provided.