A recent multicenter study demonstrated that two variants of LRRK2, S1647T and R1398H, are associated with sporadic Parkinson’s disease. The present study analyzed LRRK2 gene polymorphisms of S1647T and R1398H, demon...A recent multicenter study demonstrated that two variants of LRRK2, S1647T and R1398H, are associated with sporadic Parkinson’s disease. The present study analyzed LRRK2 gene polymorphisms of S1647T and R1398H, demonstrating that the LRRK2 gene polymorphism S1647T variant is a risk factor for Parkinson’s disease in a Chinese Han population. However, the R1398H variant did not influence the risk for Parkinson’s disease. In addition, there was no difference in clinical symptoms of Parkinson’s disease patients with various genotypes. Results showed that the LRRK2 S1647T variant was associated with an increased risk for developing early-onset Parkinson’s disease in a Chinese Han population. In addition, there was no correlation between LRRK2 S1647T, R1398H variants and G2385R, R1628P variants in Parkinson’s disease patients.展开更多
Water consumption is a key role in improving the efficiency and sustainability of water management in arid environments.In this study, we explored an approach based on meta-analysis, MODIS NDVI products, land-use spat...Water consumption is a key role in improving the efficiency and sustainability of water management in arid environments.In this study, we explored an approach based on meta-analysis, MODIS NDVI products, land-use spatial distribution, andsoil water physical parameters to gain insight into long-term and large scale distribution of land use and water consumption,maintain maximum Zhangye Oasis area according to Heihe River runoff, and suitable water resource management inZhangye Oasis. This approach was initiated in order to improve the efficiency of irrigation and water resource managementin arid regions. Results showed that Heihe River runoff can maintain a maximum Zhangye Oasis area of 22.49×104 hm2.During the 2000−2016 growing seasons, actual oasis water consumption ranged from 11.35×108 m3 to 13.73×108 m3, witha mean of (12.89 ± 0.60)×108 m3;if maintaining agricultural production and oasis stability was chosen, oasis water consumptionranged from 10.24×108 m3 to 12.37×108 m3, with a mean of (11.62 ± 0.53)×108 m3. From the perspective of waterresources management and ecosystem stability, it is necessary to reduce the area of Zhangye Oasis or choose the minimumwater consumption method to manage the oasis, to ease the pressure of water shortage and maintain stable and sustainabledevelopment of the Zhangye Oasis. These results can provide future practical guidance for water resource management ofcoordinated development of the economy and the environment in an arid area.展开更多
基金Supported by the National Natural Science Foundation of China, No. 30870846
文摘A recent multicenter study demonstrated that two variants of LRRK2, S1647T and R1398H, are associated with sporadic Parkinson’s disease. The present study analyzed LRRK2 gene polymorphisms of S1647T and R1398H, demonstrating that the LRRK2 gene polymorphism S1647T variant is a risk factor for Parkinson’s disease in a Chinese Han population. However, the R1398H variant did not influence the risk for Parkinson’s disease. In addition, there was no difference in clinical symptoms of Parkinson’s disease patients with various genotypes. Results showed that the LRRK2 S1647T variant was associated with an increased risk for developing early-onset Parkinson’s disease in a Chinese Han population. In addition, there was no correlation between LRRK2 S1647T, R1398H variants and G2385R, R1628P variants in Parkinson’s disease patients.
基金This study was funded under the National Natural Science Foundation of China project(91425302).
文摘Water consumption is a key role in improving the efficiency and sustainability of water management in arid environments.In this study, we explored an approach based on meta-analysis, MODIS NDVI products, land-use spatial distribution, andsoil water physical parameters to gain insight into long-term and large scale distribution of land use and water consumption,maintain maximum Zhangye Oasis area according to Heihe River runoff, and suitable water resource management inZhangye Oasis. This approach was initiated in order to improve the efficiency of irrigation and water resource managementin arid regions. Results showed that Heihe River runoff can maintain a maximum Zhangye Oasis area of 22.49×104 hm2.During the 2000−2016 growing seasons, actual oasis water consumption ranged from 11.35×108 m3 to 13.73×108 m3, witha mean of (12.89 ± 0.60)×108 m3;if maintaining agricultural production and oasis stability was chosen, oasis water consumptionranged from 10.24×108 m3 to 12.37×108 m3, with a mean of (11.62 ± 0.53)×108 m3. From the perspective of waterresources management and ecosystem stability, it is necessary to reduce the area of Zhangye Oasis or choose the minimumwater consumption method to manage the oasis, to ease the pressure of water shortage and maintain stable and sustainabledevelopment of the Zhangye Oasis. These results can provide future practical guidance for water resource management ofcoordinated development of the economy and the environment in an arid area.
