Gastric cancer is one of the most common malignant gastrointestinal tumors whose morbidity and mortality account for the second and third place respectively in malignant tumors in China.As an important participant in ...Gastric cancer is one of the most common malignant gastrointestinal tumors whose morbidity and mortality account for the second and third place respectively in malignant tumors in China.As an important participant in tumor biology,the abnormal expression of long non-coding RNA(lncRNAs)in cancer cells is closely related to the occurrence and development of tumors and plays the role of oncogenes or tumor suppressor genes.In this study,we identified a novel lncRNA NFIA antisense RNA 1(NFIA-AS1)and explored its role and clinical significance in gastric cancer.Real-time quantitative PCR was performed to detect the expression of NFIA-AS1 in tumor tissues and corresponding normal tissues from 42 pairs of gastric cancer samples.The lower expression of NFIA-AS1 was significantly associated with larger tumor size,lower histological grade,and advanced TNM stage.Kaplan-meier analysis showed that NFIA-AS1 expression could be used as an independent predictor of overall survival.We also demonstrated that overexpression of NFIA-AS1 significantly inhibited the proliferation of gastric cancer cells through affecting p16 levels.In conclusion,our results suggest that the lncRNA NFIA-AS1 may play the role of tumor suppressor gene,and serve as a biomarker for prognosis or progression of gastric cancer.展开更多
Data of Paleozoic and some Early Triassic vascular land plant fossils from South China are synthetically analyzed,revealing evolutionary characteristics of Paleozoic vascular land plant diversity.Vascular land plant d...Data of Paleozoic and some Early Triassic vascular land plant fossils from South China are synthetically analyzed,revealing evolutionary characteristics of Paleozoic vascular land plant diversity.Vascular land plant diversity keeps increasing in the Paleozoic as a whole.The Silurian witnessed the earliest evolution and initial diversification of land plants.From the Early Devonian to the Early Carboniferous(Mississippian),the great development,diversification,and differentiation really occurred in vascular land plants,with fluctuations of diversity,rapid replacement of the plant types,and an all-out takeover of terrestrial ecological niches.From the Early Permian,land plant diversity dramatically increased,and reached a climax in the Middle-Late Permian.Comparisons between late Paleozoic marine and terrestrial biodiversity reveal co-evolution of the late Paleozoic animals and plants as well as the individual evolutionary patterns of sea/land ecosystems.Vascular land plant diversity dramatically declined in the Frasnian as a result of the F/F event,and the end-Permian mass extinctions completely turned over the phytogroups.展开更多
基金supported by grants from the Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX17_1301 to E.Z.)the National Natural Science Foundation of China (81730066 to D.M.).
文摘Gastric cancer is one of the most common malignant gastrointestinal tumors whose morbidity and mortality account for the second and third place respectively in malignant tumors in China.As an important participant in tumor biology,the abnormal expression of long non-coding RNA(lncRNAs)in cancer cells is closely related to the occurrence and development of tumors and plays the role of oncogenes or tumor suppressor genes.In this study,we identified a novel lncRNA NFIA antisense RNA 1(NFIA-AS1)and explored its role and clinical significance in gastric cancer.Real-time quantitative PCR was performed to detect the expression of NFIA-AS1 in tumor tissues and corresponding normal tissues from 42 pairs of gastric cancer samples.The lower expression of NFIA-AS1 was significantly associated with larger tumor size,lower histological grade,and advanced TNM stage.Kaplan-meier analysis showed that NFIA-AS1 expression could be used as an independent predictor of overall survival.We also demonstrated that overexpression of NFIA-AS1 significantly inhibited the proliferation of gastric cancer cells through affecting p16 levels.In conclusion,our results suggest that the lncRNA NFIA-AS1 may play the role of tumor suppressor gene,and serve as a biomarker for prognosis or progression of gastric cancer.
基金supported by Chinese Academy of Sciences (Grant Nos. KZCX2-YW-105,KZCX2-YW-Q05-01)National Natural Science Foundation of China (Grant No. 40523004) National Basic Research Program of China (Grant No. 2006CB806400)
文摘Data of Paleozoic and some Early Triassic vascular land plant fossils from South China are synthetically analyzed,revealing evolutionary characteristics of Paleozoic vascular land plant diversity.Vascular land plant diversity keeps increasing in the Paleozoic as a whole.The Silurian witnessed the earliest evolution and initial diversification of land plants.From the Early Devonian to the Early Carboniferous(Mississippian),the great development,diversification,and differentiation really occurred in vascular land plants,with fluctuations of diversity,rapid replacement of the plant types,and an all-out takeover of terrestrial ecological niches.From the Early Permian,land plant diversity dramatically increased,and reached a climax in the Middle-Late Permian.Comparisons between late Paleozoic marine and terrestrial biodiversity reveal co-evolution of the late Paleozoic animals and plants as well as the individual evolutionary patterns of sea/land ecosystems.Vascular land plant diversity dramatically declined in the Frasnian as a result of the F/F event,and the end-Permian mass extinctions completely turned over the phytogroups.
