Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring.Here,we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and por...Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring.Here,we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition fingerprint information of targeted biomarkers including urea,lactate,and pH in sweat.A miniature,thin plasmonic metasurface with homogeneous mushroom-shaped hot spots and high surface-enhanced Raman scattering(SERS)activity is designed and integrated into a microfluidics platform.Compared to conventional wearable SERS platforms with the risk of mixed effect between new and old sweat,the microfluidic SERS system allows sweat administration in a controllable and high temporal-resolution fashion,providing refreshable SERS analysis.We use a portable and customized Raman analyzer with a friendly human-machine interface for portable recognition of the spectroscopic signatures of sweat biomarkers.This study integrates epidermal microfluidics with portable SERS molecular recognition,presenting a controllable,handy,and dynamical biofluid sensing system for personalized medicine.展开更多
The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets.Here,we integrate the jigsaw-like multifunctional min...The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets.Here,we integrate the jigsaw-like multifunctional mini-pillar platform to perform multi-mode(electrochemical,fluorescence,surface-enhanced Raman scattering(SERS)and colorimetric)sensing in individual microdroplets.Each mini-pillar connector can parallelize together by specific concave-convex interface to form integrated jigsaw-like platform for multi-mode sensing,and each specific mini-pillar can be modified into the individual sensing unit to read the prescribed signals.We successfully implemented electrochemical,fluorescence,SERS and colorimetric detection by multiple signals coupling to reduce the false positive analysis.Such platform brings a promising clue of in-situ analysis and point-of-care testing for disease diagnosis and health monitoring.展开更多
基金funding from Joint Fund of the Ministry of Education for Equipment Pre-research (8091B022142)Shenzhen Stability Support Plan (20200806163622001)Shenzhen Overseas Talent Program,and Shenzhen Key Laboratory for Nano Biosensing Technology (ZDSYS20210112161400001).
文摘Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring.Here,we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition fingerprint information of targeted biomarkers including urea,lactate,and pH in sweat.A miniature,thin plasmonic metasurface with homogeneous mushroom-shaped hot spots and high surface-enhanced Raman scattering(SERS)activity is designed and integrated into a microfluidics platform.Compared to conventional wearable SERS platforms with the risk of mixed effect between new and old sweat,the microfluidic SERS system allows sweat administration in a controllable and high temporal-resolution fashion,providing refreshable SERS analysis.We use a portable and customized Raman analyzer with a friendly human-machine interface for portable recognition of the spectroscopic signatures of sweat biomarkers.This study integrates epidermal microfluidics with portable SERS molecular recognition,presenting a controllable,handy,and dynamical biofluid sensing system for personalized medicine.
基金National Natural Science Foundation of China(Nos.21804007 and 21890742)Youth Scholars of Beijing Technology and Business University(No.QNJJ2020-04)+1 种基金SZU Top Ranking Project(No.86000000210)Shenzhen Stability Support Plan(No.20200806163622001)。
文摘The multiple sensing provides booming options to eliminate interference and ensure the accuracy of detection by mutually coupling and validating multiple data sets.Here,we integrate the jigsaw-like multifunctional mini-pillar platform to perform multi-mode(electrochemical,fluorescence,surface-enhanced Raman scattering(SERS)and colorimetric)sensing in individual microdroplets.Each mini-pillar connector can parallelize together by specific concave-convex interface to form integrated jigsaw-like platform for multi-mode sensing,and each specific mini-pillar can be modified into the individual sensing unit to read the prescribed signals.We successfully implemented electrochemical,fluorescence,SERS and colorimetric detection by multiple signals coupling to reduce the false positive analysis.Such platform brings a promising clue of in-situ analysis and point-of-care testing for disease diagnosis and health monitoring.
