Objeotive： Many studies have examined the association between the TNF-308 G/A polymorphism gene polymorphisms and hepatocellular carcinoma risk in various populations, but their results have been inconsistent. To ass...Objeotive： Many studies have examined the association between the TNF-308 G/A polymorphism gene polymorphisms and hepatocellular carcinoma risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a me：a-analysis was performed. Methods： The PubMed and CNKI （China National Knowledge Infrastructure） database was searched for case-control studies. Odds ratios （OR） with 95% CIs were used to determine the strength of association between the TNF-308 G/A polymorphisms and HCC risk. The pooled ORs for the risk associated with the TNF-308 G/A genotype, the A carriers （A/G ＋ A/A） vs. the wild-type homozygntes （G/G）, A/A vs. G/G were calculated, respectively. Subgroup analyses were done by ethnicity and smoking status. Heterogeneity assumptions were assessed by chi-square-based Q-test. Results： Ultimately, 21 studies, comprising 2,923 hepatocellular carcinoma cases and 4,323 controls were included. Overall, the A carriers （G/A ＋ A/A） vs. the wild-type homozygotes （G/G）, the pooled OR was 1.05 （95% CI, 0.93-1.19; P=0.000 for heterogeneity）, for A/A vs. G/G the pooled OR was 1.07 （95% CI, 0.95-1.21; P=0.007 for heterogeneity）. In the stratified analysis by erhnicity, the significantly risks were found among non-Asians. However, for Asians, significantly risks were not found. Conclusions： The TNF-308 G/A polymorphisms are not associated with hepatoceUular carcinoma risk among Asians, but for non-Asians.展开更多
文摘Objeotive： Many studies have examined the association between the TNF-308 G/A polymorphism gene polymorphisms and hepatocellular carcinoma risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a me：a-analysis was performed. Methods： The PubMed and CNKI （China National Knowledge Infrastructure） database was searched for case-control studies. Odds ratios （OR） with 95% CIs were used to determine the strength of association between the TNF-308 G/A polymorphisms and HCC risk. The pooled ORs for the risk associated with the TNF-308 G/A genotype, the A carriers （A/G ＋ A/A） vs. the wild-type homozygntes （G/G）, A/A vs. G/G were calculated, respectively. Subgroup analyses were done by ethnicity and smoking status. Heterogeneity assumptions were assessed by chi-square-based Q-test. Results： Ultimately, 21 studies, comprising 2,923 hepatocellular carcinoma cases and 4,323 controls were included. Overall, the A carriers （G/A ＋ A/A） vs. the wild-type homozygotes （G/G）, the pooled OR was 1.05 （95% CI, 0.93-1.19; P=0.000 for heterogeneity）, for A/A vs. G/G the pooled OR was 1.07 （95% CI, 0.95-1.21; P=0.007 for heterogeneity）. In the stratified analysis by erhnicity, the significantly risks were found among non-Asians. However, for Asians, significantly risks were not found. Conclusions： The TNF-308 G/A polymorphisms are not associated with hepatoceUular carcinoma risk among Asians, but for non-Asians.
