In this work,a bidirectional fluid-structure coupling finite element analysis model of the abdominal aorta was established,with the various vascular elastic modulus as the main parameters for atherosclerosis,taking in...In this work,a bidirectional fluid-structure coupling finite element analysis model of the abdominal aorta was established,with the various vascular elastic modulus as the main parameters for atherosclerosis,taking into consideration blood's dynamic viscosity and compressibility.Pressure and velocity pulse-wave propagation were investigated through the application of a full-coupling analysis algorithm.The effect of atherosclerosis degree on the propagation characteristics of pulse waves in the bifurcated abdominal aorta was quantitatively analyzed.Arterial bifurcation can cause substantial attenuation on the peak of pressure pulse waveform and an increase in wave velocity during the cardiac cycle.The elastic modulus and bifurcation properties of the arterial wall directly affected the peak value and wave propagation velocity of the pressure pulse wave.The preliminary results of this work will be crucial in guiding the evolution of the pressure pulse wave and the initial diagnosis of atherosclerotic disease through the waveform.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.11872218)Zhejiang Provincial Natural Science Foundation Key Projects(Grant No.LZ23A020001)+2 种基金the National Natural Science Foundation of China Regional Innovation Key Project(Grant No.U21A20502)Zhejiang Province Traditional Chinese Medicine Science and Technology Foundation(Grant No.2022ZB317)the first batch of Medical and Health Brand Discipline Foundation in Ningbo(Grant No.PPXK2018-07)。
文摘In this work,a bidirectional fluid-structure coupling finite element analysis model of the abdominal aorta was established,with the various vascular elastic modulus as the main parameters for atherosclerosis,taking into consideration blood's dynamic viscosity and compressibility.Pressure and velocity pulse-wave propagation were investigated through the application of a full-coupling analysis algorithm.The effect of atherosclerosis degree on the propagation characteristics of pulse waves in the bifurcated abdominal aorta was quantitatively analyzed.Arterial bifurcation can cause substantial attenuation on the peak of pressure pulse waveform and an increase in wave velocity during the cardiac cycle.The elastic modulus and bifurcation properties of the arterial wall directly affected the peak value and wave propagation velocity of the pressure pulse wave.The preliminary results of this work will be crucial in guiding the evolution of the pressure pulse wave and the initial diagnosis of atherosclerotic disease through the waveform.
