Dear Editor,Dendritic cells(DCs)are the most efficient professional antigen presenting cells that act as sentinels of the immune system and conduct vital functions in the initiation and regulation of innate and adapti...Dear Editor,Dendritic cells(DCs)are the most efficient professional antigen presenting cells that act as sentinels of the immune system and conduct vital functions in the initiation and regulation of innate and adaptive immunities(Wculek et al.,2020).In addition to being critical cellular components in pathogen clearance,DCs are promising targets for improved tumor immunotherapy,vaccine design,and intervention of autoimmune diseases(Nutt and Chopin,2020).DCs can be classified as plasmacytoid DCs(pDCs)and conventional DCs(cDCs)in both mouse and human(Anderson et al.,2018;Nutt and Chopin,2020).展开更多
The role of the p38 signaling pathway in the innate and adaptive immune responses has been well documented,especially in inflammatory cytokine production by dendritic cells(DCs).However,whether the p38 signaling pathw...The role of the p38 signaling pathway in the innate and adaptive immune responses has been well documented,especially in inflammatory cytokine production by dendritic cells(DCs).However,whether the p38 signaling pathway affects the important antigen(Ag)presentation function of DCs remains largely unknown.In this study,we reported that the deletion of p38αresulted in an impaired cross-presentation ability of CD8^(+) conventional DCs(cDCs)and a reduction in the direct presentation ability of CD8−cDCs ex vivo.Further study revealed that p38αhad a crucial role in Ag processing by CD8^(+) cDCs but did not affect the Ag uptake or co-stimulation of T cells.Moreover,p38αdeficiency led to reduced cross-priming of T cells in vivo.The production of the IL-12p40 and IL-12p70 cytokines by p38α-deficient cDCs was also significantly reduced.Our study identified a new role for p38αin modulating the important antigen cross-presentation function of DCs.展开更多
文摘Dear Editor,Dendritic cells(DCs)are the most efficient professional antigen presenting cells that act as sentinels of the immune system and conduct vital functions in the initiation and regulation of innate and adaptive immunities(Wculek et al.,2020).In addition to being critical cellular components in pathogen clearance,DCs are promising targets for improved tumor immunotherapy,vaccine design,and intervention of autoimmune diseases(Nutt and Chopin,2020).DCs can be classified as plasmacytoid DCs(pDCs)and conventional DCs(cDCs)in both mouse and human(Anderson et al.,2018;Nutt and Chopin,2020).
基金This work was supported by grants from the Chinese Ministry of Science and Technology National Major Scientific Research Program(2015CB943200)the Key Project Grant from the National Natural Science Foundation of China(31330027)+1 种基金the National Basic Research Program of China(2015CB553800)the Tsinghua Science Foundation(20111080963).
文摘The role of the p38 signaling pathway in the innate and adaptive immune responses has been well documented,especially in inflammatory cytokine production by dendritic cells(DCs).However,whether the p38 signaling pathway affects the important antigen(Ag)presentation function of DCs remains largely unknown.In this study,we reported that the deletion of p38αresulted in an impaired cross-presentation ability of CD8^(+) conventional DCs(cDCs)and a reduction in the direct presentation ability of CD8−cDCs ex vivo.Further study revealed that p38αhad a crucial role in Ag processing by CD8^(+) cDCs but did not affect the Ag uptake or co-stimulation of T cells.Moreover,p38αdeficiency led to reduced cross-priming of T cells in vivo.The production of the IL-12p40 and IL-12p70 cytokines by p38α-deficient cDCs was also significantly reduced.Our study identified a new role for p38αin modulating the important antigen cross-presentation function of DCs.
