A prevailing,controversial hypothesis is that fishing pressure has played a greater role than climatic and environmental drivers,in changing fish species succession and biomass fluctuation in the South China Sea(SCS)....A prevailing,controversial hypothesis is that fishing pressure has played a greater role than climatic and environmental drivers,in changing fish species succession and biomass fluctuation in the South China Sea(SCS).Based on otter trawl survey data from 1959 to 2010 in the outer Beibu Gulf(OBG),northern SCS,large seasonal and interannual variation is reported for fish species composition,the proportional abundances of dominant taxa,and fish biomass.Generalized additive models are developed to quantify relationships between fish biomass and the external factors of fishing pressure and climate change.Fishing pressure proved to be the main driver of sharp declines in demersal fish stocks,with high-value species being replaced by low-value ones over time.Abrupt decreases in fish biomass during the years of 1993 and 1998 correspond to El Nino events,with climate change possibly the main driver of proportional representation of pelagic species in fisheries trawl catch.The need to differentiate impacts of fishing and environmental drivers on fish species with different life history strategies is stressed to better understand fish community dynamics.展开更多
The pulsating heat pipe is a very promising heat dissipation device to address the challenge of higher heat-flux electronic chips,as it is characterised by excellent heat transfer ability and flexibility for miniaturi...The pulsating heat pipe is a very promising heat dissipation device to address the challenge of higher heat-flux electronic chips,as it is characterised by excellent heat transfer ability and flexibility for miniaturisation.To boost the application of PHP,reliable heat transfer performance evaluationmodels are especially important.In this paper,a heat transfer correlation was firstly proposed for closed PHP with various working fluids(water,ethanol,methanol,R123,acetone)based on collected experimental data.Dimensional analysis was used to group the parameters.It was shown that the average absolute deviation(AAD)and correlation coefficient(r)of the correlation were 40.67%and 0.7556,respectively.For 95%of the data,the prediction of thermal resistance and the temperature difference between evaporation and condensation section fell within 1.13K/Wand 40.76K,respectively.Meanwhile,an artificial neural networkmodelwas also proposed.The ANN model showed a better prediction accuracy with a mean square error(MSE)and correlation coefficient(r)of 7.88e-7 and 0.9821,respectively.展开更多
During July 2015 to June 2016, two permanent sampling sites were established in Scirpus mariqueter salt marsh and its adjacent mudflat on the intertidal zone of Chongming-Dongtan in the Yangtze Estuary. Based on month...During July 2015 to June 2016, two permanent sampling sites were established in Scirpus mariqueter salt marsh and its adjacent mudflat on the intertidal zone of Chongming-Dongtan in the Yangtze Estuary. Based on monthly trap net surveys of fishes, the characteristics of the fish assemblages in the different subhabitats, including the salt marsh and mudflat, and the monthly variations were analyzed. A total of 19 species of fishes were found belong to 12 Families. The characteristics including the dominant fish species were different in these two subhabitats. 18 species of fish were recorded in the mudflat, of which the dominant species were the Coilia ectenes, Pelteobagrus nitidus and Lateolabrax maculatus. Ten species of fish were recorded in the salt marsh of which the dominant species were the Coilia ectenes, Saurogobio dumerili, Liza haematocheila, Lateolabrax maculatus and Acanthogobius ommaturus. Pelteobagrus nitidus prefers to use the mudflat, while Lateolabrax maculatus and Liza haematocheila prefer to use the salt marsh. There was a significant difference in the monthly variation of fish abundance between the fish abundance of salt marsh and mudflat, while there was no significant difference in fish biomass. The Simpson index of the fish of the mudflat was significantly higher than that of the salt marsh, while the Margalef index and the Pielou index were lower than the salt marsh. The community can be divided into two groups: winter-spring (A) and summer-autumn (B). The abundance of fish in the mudflat and the salt marsh show a very significant correlation with the water temperature (r = 0.773, 0.830, respectively) and a significant correlation with the water salinity(r = 0.654, 0.648, respectively). The abundance of fish in mudflat and salt marsh are both significantly correlated with water temperature and salinity. The abundance of fish of the mudflat (r = 0.470, P > 0.05) is more related to the highest submerged depth than of the salt marsh (r = 0.087, P > 0.05).展开更多
Network moral education has three connotations including discourse right,discourse power and discourse effectiveness,and four characteristics including interactivity,diversity,symbolism and implicity.These characteris...Network moral education has three connotations including discourse right,discourse power and discourse effectiveness,and four characteristics including interactivity,diversity,symbolism and implicity.These characteristics to a certain extent make the position and function between the subject and object of network education change,resulting in the discourse power and discourse effectiveness out of sync.Therefore,when solving these problems,we should take the ideological beliefs as the leading point,use the new media technology means,take the discourse power construction as the starting point,occupy the discourse highland and manifest the representation.At the same time,we should take life practice as the standard,change the discourse,break the implicity,and put the initiative of network moral education in the hands of educators.展开更多
肱二头肌长头腱(long head of the biceps tendon,LHBT)绝大部分起自盂上结节和上盂唇,少部分起自盂唇的其他位置,是人体唯一分为关节内段和关节外段肌腱。LHBT的主要功能是曲肘和使前臂旋后,但其在肩部的功能尚存在争议。单纯的LHBT损...肱二头肌长头腱(long head of the biceps tendon,LHBT)绝大部分起自盂上结节和上盂唇,少部分起自盂唇的其他位置,是人体唯一分为关节内段和关节外段肌腱。LHBT的主要功能是曲肘和使前臂旋后,但其在肩部的功能尚存在争议。单纯的LHBT损伤少见,约95%的LHBT损伤多与结节间沟解剖、肩袖损伤、肩峰撞击综合征、肩锁关节紊乱和肩关节前上撞击综合征等疾病有关,明确诊断仍有一定的难度。目前,LHBT损伤机制包括:LHBT肌腱炎或腱鞘炎、LHBT半脱位或脱位、LHBT部分撕裂或完全断裂、肩关节上盂唇损伤、滑车结构损伤。LHBT损伤分型大致分为直接损伤与间接损伤。由于LHBT损伤常伴随肩关节的其他疾病,明确诊断仍有一定的难度,需要结合病史、体格检查和影像学检查,甚至需要有经验的医师反复体格检查及查阅影像学资料后才可确诊。本文从肱二头肌长头腱损伤的解剖、生物力学功能、损伤机制与分型、组织病理研究和诊断进行综述报道,有望对肱二头肌长头腱损伤患者的诊断提供参考。展开更多
The use of a reconfigurable intelligent surface(RIS)in the enhancement of the rate performance is considered to involve the limitation of the RIS being a passive reflector.To address this issue,we propose a RIS-aided ...The use of a reconfigurable intelligent surface(RIS)in the enhancement of the rate performance is considered to involve the limitation of the RIS being a passive reflector.To address this issue,we propose a RIS-aided amplify-and-forward(AF)relay network in this paper.By jointly optimizing the beamforming matrix at AF relay and the phase-shift matrices at RIS,two schemes are put forward to address a maximizing signal-to-noise ratio(SNR)problem.First,aiming at achieving a high rate,a high-performance alternating optimization(AO)method based on Charnes–Cooper transformation and semidefinite programming(CCT-SDP)is proposed,where the optimization problem is decomposed into three subproblems solved using CCT-SDP,and rank-one solutions can be recovered using Gaussian randomization.However,the optimization variables in the CCT-SDP method are matrices,leading to extremely high complexity.To reduce the complexity,a low-complexity AO scheme based on Dinkelbachs transformation and successive convex approximation(DT-SCA)is proposed,where the variables are represented in vector form,and the three decoupling subproblems are solved using DT-SCA.Simulation results verify that compared to three benchmarks(i.e.,a RIS-assisted AF relay network with random phase,an AF relay network without RIS,and a RIS-aided network without AF relay),the proposed CCT-SDP and DT-SCA schemes can harvest better rate performance.Furthermore,it is revealed that the rate of the low-complexity DT-SCA method is close to that of the CCT-SDP method.展开更多
Indium tin oxide (ITO) films were fabricated on polyethylene terephthalate (PET) substrate at room tem- perature using dc magnetron sputtering technique with different sputtering powers. The structural, electrical and...Indium tin oxide (ITO) films were fabricated on polyethylene terephthalate (PET) substrate at room tem- perature using dc magnetron sputtering technique with different sputtering powers. The structural, electrical and optical properties were investigated by X-ray diffraction (XRD), Hall effect, reflection and transmission, respectively. XRD patterns show gradual enhancement of crystalline quality with increasing sputtering power. Significant improvement of Hall mobility due to the reduction of defects was observed though the carrier density varied slightly. Simultaneously, the mean transmission in visible light range decreased severely with increasing sputtering power. Slight move toward shorter-wavelength side of absorption peak was due to the variation of plasma wavelength. The reflection increase of near-infrared light originated from the decrease of resistivity. Finally, band gap was obtained using Tauc s relation and it was consistent with Burstein-Moss shift.展开更多
One-step precipitation of Ag nanoparticles in Ag+-doped silicate glasses was achieved through a focused picosecond laser with a high repetition rate. Absorption spectra and transmission electron microscopy(TEM) confir...One-step precipitation of Ag nanoparticles in Ag+-doped silicate glasses was achieved through a focused picosecond laser with a high repetition rate. Absorption spectra and transmission electron microscopy(TEM) confirmed that metallic Ag nanoparticles were precipitated within glass samples in the laser-written domain. The surface plasmon absorbance fits well with the experimental absorption spectrum. The nonlinear absorption coefficient β is determined to be 2.47 × 10-14 m/W by fitting the open aperture Z-scan curve, which originated from the intraband transition in the s-p Ag band. The formation mechanism of Ag-glass nanocomposites is discussed as well.展开更多
An overview of current thermal challenges in transport electrification is introduced in order to underpin the research developments and trends of recent thermal management techniques.Currently,explorations of intellig...An overview of current thermal challenges in transport electrification is introduced in order to underpin the research developments and trends of recent thermal management techniques.Currently,explorations of intelligent thermal management and control strategies prevail among car manufacturers in the context of climate change and global warming impacts.Therefore,major cutting-edge systematic approaches in electrified powertrain are summarized in the first place.In particular,the important role of heating,ventilation and air-condition system(HVAC)is emphasised.The trends in developing efficient HVAC system for future electrified powertrain are analysed.Then electric machine efficiency is under spotlight which could be improved by introducing new thermal management techniques and strengthening the efforts of driveline integrations.The demanded integration efforts are expected to provide better value per volume,or more power output/torque per unit with smaller form factor.Driven by demands,major thermal issues of high-power density machines are raised including the comprehensive understanding of thermal path,and multiphysics challenges are addressed whilst embedding power electronic semiconductors,non-isotropic electromagnetic materials and thermal insulation materials.Last but not least,the present review has listed several typical cooling techniques such as liquid cooling jacket,impingement/spray cooling and immersion cooling that could be applied to facilitate the development of integrated electric machine,and a mechanic-electric-thermal holistic approach is suggested at early design phase.Conclusively,a brief summary of the emerging new cooling techniques is presented and the keys to a successful integration are concluded.展开更多
Glioma is the most common type of tumor in the central nervous system, accounting for around 80% of all malignant brain tumors. Previous studies showed a significant association between nuclear morphology and the mali...Glioma is the most common type of tumor in the central nervous system, accounting for around 80% of all malignant brain tumors. Previous studies showed a significant association between nuclear morphology and the malignant progress of gliomas. By virtue of integrated proteomics and genomics analyses as well as experimental validations, we identify three nuclear lamin genes(LMNA, LMNB1, and LMNB2) that are significantly upregulated in glioma tissues compared with normal brain tissues. We show that elevated expressions of LMNB1, LMNB2, and LMNA in glioma cells are highly associated with the rapid progression of the disease and the knockdown of LMNB1, LMNB2, and LMNA dramatically suppresses glioma progression in both in vitro and in vivo mouse models. Moreover, the repression of glioma cell growth by lamin knockdown is mediated by the p Rb-mediated G1-S inhibition. On the contrary, overexpression of lamins in normal human astrocytes dramatically induced nuclear morphological aberrations and accelerated cell growth. Together, our multi-omics-based analysis has revealed a previously unrecognized role of lamin genes in gliomagenesis, providing a strong support for the key link between aberrant tumor nuclear shape and the survival of glioma patients. Based on these findings, lamins are proposed to be potential oncogene targets for therapeutic treatments of brain tumors.展开更多
Dear Editor:Lung cancer has the highest incidence rate among malignancies and remains the primary contributor to cancer-related mortality on a global scale[1].Early detection is the most efficacious approach for enhan...Dear Editor:Lung cancer has the highest incidence rate among malignancies and remains the primary contributor to cancer-related mortality on a global scale[1].Early detection is the most efficacious approach for enhancing the prognosis and mitigating the mortality of patients with lung cancer[2].Currently,diagnosis of lung cancer is mainly by different types of imaging including low-dose spiral computed tomography(LDCT)combined with pathological assessment of biopsy,but prevalence of false-positive results and associated expenses may impede its becoming a standard screening technique[3].展开更多
基金The Science and Technology Basic Resources Investigation Program of China under contract No.2017FY201405the Open Research Fund Program of Guangxi Key Lab of Mangrove Conservation and Utilization under contract No.GKLMC-201403+2 种基金the National Natural Science Foundation of China under contract No.41666008the Fund of Key Laboratory of Open-Sea Fishery Development,Ministry of Agriculture of China under contract No.LOF 2018-01the Natural Science Foundation of Guangxi under contract No.2016GXNSFDA380035
文摘A prevailing,controversial hypothesis is that fishing pressure has played a greater role than climatic and environmental drivers,in changing fish species succession and biomass fluctuation in the South China Sea(SCS).Based on otter trawl survey data from 1959 to 2010 in the outer Beibu Gulf(OBG),northern SCS,large seasonal and interannual variation is reported for fish species composition,the proportional abundances of dominant taxa,and fish biomass.Generalized additive models are developed to quantify relationships between fish biomass and the external factors of fishing pressure and climate change.Fishing pressure proved to be the main driver of sharp declines in demersal fish stocks,with high-value species being replaced by low-value ones over time.Abrupt decreases in fish biomass during the years of 1993 and 1998 correspond to El Nino events,with climate change possibly the main driver of proportional representation of pelagic species in fisheries trawl catch.The need to differentiate impacts of fishing and environmental drivers on fish species with different life history strategies is stressed to better understand fish community dynamics.
基金This work is funded by National Natural Science Foundation of China(No.51906216).
文摘The pulsating heat pipe is a very promising heat dissipation device to address the challenge of higher heat-flux electronic chips,as it is characterised by excellent heat transfer ability and flexibility for miniaturisation.To boost the application of PHP,reliable heat transfer performance evaluationmodels are especially important.In this paper,a heat transfer correlation was firstly proposed for closed PHP with various working fluids(water,ethanol,methanol,R123,acetone)based on collected experimental data.Dimensional analysis was used to group the parameters.It was shown that the average absolute deviation(AAD)and correlation coefficient(r)of the correlation were 40.67%and 0.7556,respectively.For 95%of the data,the prediction of thermal resistance and the temperature difference between evaporation and condensation section fell within 1.13K/Wand 40.76K,respectively.Meanwhile,an artificial neural networkmodelwas also proposed.The ANN model showed a better prediction accuracy with a mean square error(MSE)and correlation coefficient(r)of 7.88e-7 and 0.9821,respectively.
文摘During July 2015 to June 2016, two permanent sampling sites were established in Scirpus mariqueter salt marsh and its adjacent mudflat on the intertidal zone of Chongming-Dongtan in the Yangtze Estuary. Based on monthly trap net surveys of fishes, the characteristics of the fish assemblages in the different subhabitats, including the salt marsh and mudflat, and the monthly variations were analyzed. A total of 19 species of fishes were found belong to 12 Families. The characteristics including the dominant fish species were different in these two subhabitats. 18 species of fish were recorded in the mudflat, of which the dominant species were the Coilia ectenes, Pelteobagrus nitidus and Lateolabrax maculatus. Ten species of fish were recorded in the salt marsh of which the dominant species were the Coilia ectenes, Saurogobio dumerili, Liza haematocheila, Lateolabrax maculatus and Acanthogobius ommaturus. Pelteobagrus nitidus prefers to use the mudflat, while Lateolabrax maculatus and Liza haematocheila prefer to use the salt marsh. There was a significant difference in the monthly variation of fish abundance between the fish abundance of salt marsh and mudflat, while there was no significant difference in fish biomass. The Simpson index of the fish of the mudflat was significantly higher than that of the salt marsh, while the Margalef index and the Pielou index were lower than the salt marsh. The community can be divided into two groups: winter-spring (A) and summer-autumn (B). The abundance of fish in the mudflat and the salt marsh show a very significant correlation with the water temperature (r = 0.773, 0.830, respectively) and a significant correlation with the water salinity(r = 0.654, 0.648, respectively). The abundance of fish in mudflat and salt marsh are both significantly correlated with water temperature and salinity. The abundance of fish of the mudflat (r = 0.470, P > 0.05) is more related to the highest submerged depth than of the salt marsh (r = 0.087, P > 0.05).
文摘Network moral education has three connotations including discourse right,discourse power and discourse effectiveness,and four characteristics including interactivity,diversity,symbolism and implicity.These characteristics to a certain extent make the position and function between the subject and object of network education change,resulting in the discourse power and discourse effectiveness out of sync.Therefore,when solving these problems,we should take the ideological beliefs as the leading point,use the new media technology means,take the discourse power construction as the starting point,occupy the discourse highland and manifest the representation.At the same time,we should take life practice as the standard,change the discourse,break the implicity,and put the initiative of network moral education in the hands of educators.
文摘肱二头肌长头腱(long head of the biceps tendon,LHBT)绝大部分起自盂上结节和上盂唇,少部分起自盂唇的其他位置,是人体唯一分为关节内段和关节外段肌腱。LHBT的主要功能是曲肘和使前臂旋后,但其在肩部的功能尚存在争议。单纯的LHBT损伤少见,约95%的LHBT损伤多与结节间沟解剖、肩袖损伤、肩峰撞击综合征、肩锁关节紊乱和肩关节前上撞击综合征等疾病有关,明确诊断仍有一定的难度。目前,LHBT损伤机制包括:LHBT肌腱炎或腱鞘炎、LHBT半脱位或脱位、LHBT部分撕裂或完全断裂、肩关节上盂唇损伤、滑车结构损伤。LHBT损伤分型大致分为直接损伤与间接损伤。由于LHBT损伤常伴随肩关节的其他疾病,明确诊断仍有一定的难度,需要结合病史、体格检查和影像学检查,甚至需要有经验的医师反复体格检查及查阅影像学资料后才可确诊。本文从肱二头肌长头腱损伤的解剖、生物力学功能、损伤机制与分型、组织病理研究和诊断进行综述报道,有望对肱二头肌长头腱损伤患者的诊断提供参考。
基金Project supported by the National Natural Science Foundation of China(Nos.U22A2002,62071234)the Hainan Province Science and Technology Special Fund,China(No.ZDKJ2021022)the Scientific Research Fund Project of Hainan University,China(No.KYQD(ZR)-21008)。
文摘The use of a reconfigurable intelligent surface(RIS)in the enhancement of the rate performance is considered to involve the limitation of the RIS being a passive reflector.To address this issue,we propose a RIS-aided amplify-and-forward(AF)relay network in this paper.By jointly optimizing the beamforming matrix at AF relay and the phase-shift matrices at RIS,two schemes are put forward to address a maximizing signal-to-noise ratio(SNR)problem.First,aiming at achieving a high rate,a high-performance alternating optimization(AO)method based on Charnes–Cooper transformation and semidefinite programming(CCT-SDP)is proposed,where the optimization problem is decomposed into three subproblems solved using CCT-SDP,and rank-one solutions can be recovered using Gaussian randomization.However,the optimization variables in the CCT-SDP method are matrices,leading to extremely high complexity.To reduce the complexity,a low-complexity AO scheme based on Dinkelbachs transformation and successive convex approximation(DT-SCA)is proposed,where the variables are represented in vector form,and the three decoupling subproblems are solved using DT-SCA.Simulation results verify that compared to three benchmarks(i.e.,a RIS-assisted AF relay network with random phase,an AF relay network without RIS,and a RIS-aided network without AF relay),the proposed CCT-SDP and DT-SCA schemes can harvest better rate performance.Furthermore,it is revealed that the rate of the low-complexity DT-SCA method is close to that of the CCT-SDP method.
基金supported by the National Natural Science Foundation of China (No. 51071038)Program forNew Century Excellent Talents in University (NCET-09-0265)+1 种基金Sichuan Province Science Foundation for Youths(No. 2010JQ0002)State Key Laboratory for Mechanical Behavior of Materials, Xi an Jiaotong University(No. 201011005)
文摘Indium tin oxide (ITO) films were fabricated on polyethylene terephthalate (PET) substrate at room tem- perature using dc magnetron sputtering technique with different sputtering powers. The structural, electrical and optical properties were investigated by X-ray diffraction (XRD), Hall effect, reflection and transmission, respectively. XRD patterns show gradual enhancement of crystalline quality with increasing sputtering power. Significant improvement of Hall mobility due to the reduction of defects was observed though the carrier density varied slightly. Simultaneously, the mean transmission in visible light range decreased severely with increasing sputtering power. Slight move toward shorter-wavelength side of absorption peak was due to the variation of plasma wavelength. The reflection increase of near-infrared light originated from the decrease of resistivity. Finally, band gap was obtained using Tauc s relation and it was consistent with Burstein-Moss shift.
基金supported by the National Key Research and Development Program of China (No. 2016YFB1102405)National Natural Science Foundation of China (No. 61675214)Shanghai Sailing Program (No. 20YF1455200)。
文摘One-step precipitation of Ag nanoparticles in Ag+-doped silicate glasses was achieved through a focused picosecond laser with a high repetition rate. Absorption spectra and transmission electron microscopy(TEM) confirmed that metallic Ag nanoparticles were precipitated within glass samples in the laser-written domain. The surface plasmon absorbance fits well with the experimental absorption spectrum. The nonlinear absorption coefficient β is determined to be 2.47 × 10-14 m/W by fitting the open aperture Z-scan curve, which originated from the intraband transition in the s-p Ag band. The formation mechanism of Ag-glass nanocomposites is discussed as well.
基金This project has been supported in the frame of the BIS-Funded Programme 113167the Royal Society project 1130182 and European Union project H2020-MSCA-RISE 778104.
文摘An overview of current thermal challenges in transport electrification is introduced in order to underpin the research developments and trends of recent thermal management techniques.Currently,explorations of intelligent thermal management and control strategies prevail among car manufacturers in the context of climate change and global warming impacts.Therefore,major cutting-edge systematic approaches in electrified powertrain are summarized in the first place.In particular,the important role of heating,ventilation and air-condition system(HVAC)is emphasised.The trends in developing efficient HVAC system for future electrified powertrain are analysed.Then electric machine efficiency is under spotlight which could be improved by introducing new thermal management techniques and strengthening the efforts of driveline integrations.The demanded integration efforts are expected to provide better value per volume,or more power output/torque per unit with smaller form factor.Driven by demands,major thermal issues of high-power density machines are raised including the comprehensive understanding of thermal path,and multiphysics challenges are addressed whilst embedding power electronic semiconductors,non-isotropic electromagnetic materials and thermal insulation materials.Last but not least,the present review has listed several typical cooling techniques such as liquid cooling jacket,impingement/spray cooling and immersion cooling that could be applied to facilitate the development of integrated electric machine,and a mechanic-electric-thermal holistic approach is suggested at early design phase.Conclusively,a brief summary of the emerging new cooling techniques is presented and the keys to a successful integration are concluded.
基金supported by grants from High-level students returning to China (team) project in Hangzhou (2017)Zhejiang Provincial Natural Science Foundation of China (LY19C090002, LQ18C090005)Hangzhou Agriculture and Social Development Project (20191203B20)。
文摘Glioma is the most common type of tumor in the central nervous system, accounting for around 80% of all malignant brain tumors. Previous studies showed a significant association between nuclear morphology and the malignant progress of gliomas. By virtue of integrated proteomics and genomics analyses as well as experimental validations, we identify three nuclear lamin genes(LMNA, LMNB1, and LMNB2) that are significantly upregulated in glioma tissues compared with normal brain tissues. We show that elevated expressions of LMNB1, LMNB2, and LMNA in glioma cells are highly associated with the rapid progression of the disease and the knockdown of LMNB1, LMNB2, and LMNA dramatically suppresses glioma progression in both in vitro and in vivo mouse models. Moreover, the repression of glioma cell growth by lamin knockdown is mediated by the p Rb-mediated G1-S inhibition. On the contrary, overexpression of lamins in normal human astrocytes dramatically induced nuclear morphological aberrations and accelerated cell growth. Together, our multi-omics-based analysis has revealed a previously unrecognized role of lamin genes in gliomagenesis, providing a strong support for the key link between aberrant tumor nuclear shape and the survival of glioma patients. Based on these findings, lamins are proposed to be potential oncogene targets for therapeutic treatments of brain tumors.
基金supported by the National Natural Science Foundation of China (Grant No.82200078)the Interdisciplinary Innovation Project Fund of West China Hospital of Sichuan University (Grant No.ZYJC21054).
文摘Dear Editor:Lung cancer has the highest incidence rate among malignancies and remains the primary contributor to cancer-related mortality on a global scale[1].Early detection is the most efficacious approach for enhancing the prognosis and mitigating the mortality of patients with lung cancer[2].Currently,diagnosis of lung cancer is mainly by different types of imaging including low-dose spiral computed tomography(LDCT)combined with pathological assessment of biopsy,but prevalence of false-positive results and associated expenses may impede its becoming a standard screening technique[3].