Skin,as the outmost layer of human body,is frequently exposed to environmental stressors including pollutants and ultraviolet(UV),which could lead to skin disorders.Generally,skin response process to ultraviolet B(UVB...Skin,as the outmost layer of human body,is frequently exposed to environmental stressors including pollutants and ultraviolet(UV),which could lead to skin disorders.Generally,skin response process to ultraviolet B(UVB)irradiation is a nonlinear dynamic process,with unknown underlying molecular mechanism of critical transition.Here,the landscape dynamic network biomarker(lDNB)analysis of time series transcriptome data on 3D skin model was conducted to reveal the complicated process of skin response to UV irradiation at both molecular and network levels.The advanced l-DNB analysis approach showed that:(i)there was a tipping point before critical transition state during pigmentation process,validated by 3D skin model;(ii)13 core DNB genes were identified to detect the tipping point as a network biomarker,supported by computational assessment;(iii)core DNB genes such as COL7A1 and CTNNB1 can effectively predict skin lightening,validated by independent human skin data.Overall,this study provides new insights for skin response to repetitive UVB irradiation,including dynamic pathway pattern,biphasic response,and DNBs for skin lightening change,and enables us to further understand the skin resilience process after external stress.展开更多
In the originally published version of this article(p.822),there was an error in the second affiliation of author Chengming Zhang.The erroneous affiliation was given as‘University of the Chinese Academy of Sciences’...In the originally published version of this article(p.822),there was an error in the second affiliation of author Chengming Zhang.The erroneous affiliation was given as‘University of the Chinese Academy of Sciences’.This has now been corrected to‘University of Chinese Academy of Sciences’.展开更多
基金partially supported by the National Natural Science Foundation of China(31930022,31771476,12026608,12042104,and 11871456)the Strategic Priority Project of CAS(XDB38040400)+1 种基金the National Key R&D Program of China(2017YFA0505500)JST Moonshot R&D program(JP MJMS2021 to L.C.).
文摘Skin,as the outmost layer of human body,is frequently exposed to environmental stressors including pollutants and ultraviolet(UV),which could lead to skin disorders.Generally,skin response process to ultraviolet B(UVB)irradiation is a nonlinear dynamic process,with unknown underlying molecular mechanism of critical transition.Here,the landscape dynamic network biomarker(lDNB)analysis of time series transcriptome data on 3D skin model was conducted to reveal the complicated process of skin response to UV irradiation at both molecular and network levels.The advanced l-DNB analysis approach showed that:(i)there was a tipping point before critical transition state during pigmentation process,validated by 3D skin model;(ii)13 core DNB genes were identified to detect the tipping point as a network biomarker,supported by computational assessment;(iii)core DNB genes such as COL7A1 and CTNNB1 can effectively predict skin lightening,validated by independent human skin data.Overall,this study provides new insights for skin response to repetitive UVB irradiation,including dynamic pathway pattern,biphasic response,and DNBs for skin lightening change,and enables us to further understand the skin resilience process after external stress.
文摘In the originally published version of this article(p.822),there was an error in the second affiliation of author Chengming Zhang.The erroneous affiliation was given as‘University of the Chinese Academy of Sciences’.This has now been corrected to‘University of Chinese Academy of Sciences’.
