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An improved large eddy simulation of two-phase flows in a pump impeller 被引量:10
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作者 xuelin tang Fujun Wang Yulin Wu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2007年第6期635-643,共9页
An improved large eddy simulation using a dynamic second-order sub-grid-scale (SGS) stress model has been developed to model the governing equations of dense turbulent particle-liquid two-phase flows in a rotating c... An improved large eddy simulation using a dynamic second-order sub-grid-scale (SGS) stress model has been developed to model the governing equations of dense turbulent particle-liquid two-phase flows in a rotating coordinate system, and continuity is conserved by a mass-weighted method to solve the filtered governing equations. In the cur- rent second-order SGS model, the SGS stress is a function of both the resolved strain-rate and rotation-rate tensors, and the model parameters are obtained from the dimensional consistency and the invariants of the strain-rate and the rotation-rate tensors. In the numerical calculation, the finite volume method is used to discretize the governing equations with a staggered grid system. The SIMPLEC algorithm is applied for the solution of the discretized governing equations. Body- fitted coordinates are used to simulate the two-phase flows in complex geometries. Finally the second-order dynamic SGS model is successfully applied to simulate the dense turbu-lent particle-liquid two-phase flows in a centrifugal impeller. The predicted pressure and velocity distributions are in good agreement with experimental results. 展开更多
关键词 Large eddy simulation Second-order sub-grid-scale stress model Turbulent two-phase flow Pump impeller
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大剂量维生素B_(6)对严重创伤后应激性肝损伤治疗作用的实验研究
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作者 张寅杰 王之怀 +5 位作者 唐雪琳 高鹏 朱春富 贾中芝 秦锡虎 岳茂兴 《中华卫生应急电子杂志》 2023年第5期285-292,共8页
目的观察大剂量维生素B_(6)对严重创伤后应激性肝损伤(HSI)的影响。方法将HepG2细胞按维生素B_(6)终浓度0、0.5、1、2、4 mmol/L培养24 h后,使用CCK8试剂盒测定IC50。选用雄性SD大鼠按随机数字表法分为假模型组(n=30)、假模型+B_(6)组(n... 目的观察大剂量维生素B_(6)对严重创伤后应激性肝损伤(HSI)的影响。方法将HepG2细胞按维生素B_(6)终浓度0、0.5、1、2、4 mmol/L培养24 h后,使用CCK8试剂盒测定IC50。选用雄性SD大鼠按随机数字表法分为假模型组(n=30)、假模型+B_(6)组(n=30)、创伤组(n=30)、创伤+B_(6)组(n=30),每个时间点(12、24、36、48和72 h)各6只。创伤组、创伤+B_(6)组予腹壁损伤、双侧股骨骨折、单侧颅脑损伤、失血20%建立多发伤模型后予补液复苏。假模型组及假模型+B_(6)组大鼠行股动脉穿刺抽血后,予补液复苏。复苏完成后12、24、36、48、72 h处死大鼠,留取血标本及肝脏组织。采用全自动生化仪检测丙氨酸氨基转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)水平。苏木素-伊红(HE)染色、油红染色、透射电子显微镜观察大鼠肝脏组织病理学变化。结果HepG2细胞的维生素B_(6)IC50值为4 mmol/L。本研究维生素B_(6)使用剂量在安全范围内。与假模型组、假模型+B_(6)组相比,大鼠严重创伤后12、24、36 h血清ALT、AST水平逐渐升高,48、72h血清ALT、AST水平逐渐下降。创伤+B_(6)组的12、36、72h血清ALT水平显著均低于创伤组[(121.78±2.38)U/L比(177.41±6.00)U/L;(299.05±18.54)U/L比(447.03±22.02)U/L;(35.01±1.47)U/L比(48.32±4.79)U/L,P均<0.05]。创伤+B_(6)组的12、24、36、48h的血清AST水平显著均低于创伤组[(601.52±17.27)U/L比(726.66±22.20)U/L;(619.44±45.05)U/L比(779.81±27.29)U/L;(672.36±16.50)U/L比(871.61±20.23)U/L;(133.26±19.11)U/L比(285.13±31.28 U/L),P均<0.05]。HE染色可见大鼠肝脏损伤区在创伤后12 h集中于中央静脉与小叶间静脉的肝细胞。创伤后24、36h,肝损伤区域向中央静脉周围肝细胞和小叶间血管周围肝细胞进展。创伤后48、72h,肝损伤区域固定并逐渐缩小。各时间点创伤+B_(6)组大鼠的肝细胞损伤范围及程度较创伤组均明显减轻。创伤后36 h油红染色显示创伤+B_(6)组大鼠肝细胞内脂滴的数量及直径较创伤组明显下调。创伤后36 h透射电镜可见创伤+B_(6)组肝组织较创伤组线粒体肿胀减轻,嵴恢复,可见杆状线粒体,脂滴、自噬前体、自噬小体、自噬溶酶体明显减少。结论大剂量维生素B_(6)可通过减轻肝脏水肿变性及微泡性脂肪变性,减轻由严重创伤引起的HSI。创伤后36 h可能是创伤后HSI转归的重要时间点。 展开更多
关键词 维生素B_(6) 创伤 应激 肝损伤
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Applications of Three-Dimensional LBM-LES Combined Model for Pump Intakes 被引量:1
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作者 Miao Guo xuelin tang +2 位作者 Yanwen Su Xiaoqin Li Fujun Wang 《Communications in Computational Physics》 SCIE 2018年第6期104-122,共19页
Lattice Boltzmannmodel(LBM)in conjunction with an accurate Large Eddy Simulation(LES)technology was proposed to simulate various vortical structures and their evolutions in open pump intakes.The strain rate tensor in ... Lattice Boltzmannmodel(LBM)in conjunction with an accurate Large Eddy Simulation(LES)technology was proposed to simulate various vortical structures and their evolutions in open pump intakes.The strain rate tensor in the LES model is locally calculated by means of non-equilibrium moments based on Chapman-Enskog expansion,and bounce-back scheme was used for non-slip condition on solid walls and reflection scheme for free surface.The presentedmodel was applied to investigate free-surface and wall-attached vortices for different water levels and flow rate.The vortex position,shapes and vorticities were predicted successfully under three flowing cases(i.e.critical water level(CWL),lower water level,lower flow rate),and the numerical velocity and streamline distribution were analyzed systematically.For CWL based on Froude number considering open channel flows,the shape and the location of various dynamic vortices were captured.Compare to the experimental results of CWL,more vortices were predicted for lower water level,and less vortices were observed for lower flow rate.The predicted velocities and vortex locations are in good agreement with the experimental of a small physical model.The comparisons demonstrated the feasibility and stability of above-mentioned model and numerical method in predicting vortex flows inside open pump intakes. 展开更多
关键词 Lattice Boltzmannmodel Large Eddy Simulation free-surface vortices wall-attached vortices open pump intakes
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