Land Use/Cover Change (LUCC) has an impact on AOD to a certain extent. It is of great significance for ecological environment and public health to pay attention to and explore the response mechanism of AOD to LUCC. Ba...Land Use/Cover Change (LUCC) has an impact on AOD to a certain extent. It is of great significance for ecological environment and public health to pay attention to and explore the response mechanism of AOD to LUCC. Based on remote sensing satellite technology, using landsat8 and MODIS data, this paper analyzes the correlation between different land use types and AOD in Beibu Gulf coastal urban belt under the background of wide-scale region and long time series, and further discusses the difference value and contribution level of each LUCC to AOD. The results show that: 1) there is a positive correlation between PM concentration and cultivated land, urban land, water area and other types of land, and the correlation coefficient increases in turn, R is 0.812, 0.685, 0.627, 0.416, respectively, which indicates that the increase of cultivated land and urban land increases PM concentration to a certain extent;2) there is a significant negative correlation between PM concentration and forest land, R is -0.924, The results show that the decrease of woodland is an important factor for the increase of atmospheric particulate matter concentration in the study area from 2015 to 2019;3) through the contribution analysis method, the contribution of cultivated land to AOD is the largest, followed by urban land, and the water area is the smallest in 2015-2019, which indicates that the land use mode is closely related to AOD. It can be helpful to reasonably plan land use types and scientifically optimize land use structure. It can effectively reduce the concentration of air pollution particles.展开更多
The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effe...The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their monotherapy.However,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor site.Herein,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–guest complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer coating.Both Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization capacity.In view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in vitro.Particularly,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free Ce6.As expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 tumor-bearingmice.More importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/NPs.Overall,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment.展开更多
文摘Land Use/Cover Change (LUCC) has an impact on AOD to a certain extent. It is of great significance for ecological environment and public health to pay attention to and explore the response mechanism of AOD to LUCC. Based on remote sensing satellite technology, using landsat8 and MODIS data, this paper analyzes the correlation between different land use types and AOD in Beibu Gulf coastal urban belt under the background of wide-scale region and long time series, and further discusses the difference value and contribution level of each LUCC to AOD. The results show that: 1) there is a positive correlation between PM concentration and cultivated land, urban land, water area and other types of land, and the correlation coefficient increases in turn, R is 0.812, 0.685, 0.627, 0.416, respectively, which indicates that the increase of cultivated land and urban land increases PM concentration to a certain extent;2) there is a significant negative correlation between PM concentration and forest land, R is -0.924, The results show that the decrease of woodland is an important factor for the increase of atmospheric particulate matter concentration in the study area from 2015 to 2019;3) through the contribution analysis method, the contribution of cultivated land to AOD is the largest, followed by urban land, and the water area is the smallest in 2015-2019, which indicates that the land use mode is closely related to AOD. It can be helpful to reasonably plan land use types and scientifically optimize land use structure. It can effectively reduce the concentration of air pollution particles.
基金supported by National Natural Science Foundation of China (No.81973662)Distinguished Young Scholar of Sichuan Provincial Science and Technology Department (No.2019JDJQ0049)111 Project (No.B18035)
文摘The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their monotherapy.However,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor site.Herein,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–guest complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer coating.Both Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization capacity.In view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in vitro.Particularly,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free Ce6.As expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 tumor-bearingmice.More importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/NPs.Overall,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment.
