Objective:The aim of this study was to explore the difference of long-term prognosis of different treatment regimens in patients with stage ⅠB2, ⅡA2 cervical cancer. Methods:From August 1995 to September 2005, radic...Objective:The aim of this study was to explore the difference of long-term prognosis of different treatment regimens in patients with stage ⅠB2, ⅡA2 cervical cancer. Methods:From August 1995 to September 2005, radical hysterectomy was chosen as primary treatment regimen for 122 patients (group A), 85 patients underwent radical hysterectomy after effective neoadjuvant therapy (group B), and 98 patients received surgery after ineffective preoperative therapy (group C). All patients received postoperative therapy. Results:A total of 305 patients were analyzed. The maximum diameter of tumor was largest in group B, while the pathological risk factors (cervical infiltration, positive surgical margins) were in the lowest proportion. The 5-year mortality rate and relapse rate of group B were the highest, and the overall survival (OS) and progression-free survival (PFS) were the shortest (P < 0.05). No significant difference of long-term survival was found in group C and group A. No difference was found in the surgical of three groups. Large tumor more than 5.5 cm had higher effective ratio of treatment than those 5.5 cm or less. Patients received effective preoperative radiotherapy had better long-term prognosis than those received chemotherapy or radiochemotherapy. Conclusion:neoadjuvant treatment using for patients with ⅠB2, ⅡA2 cervical cancer is effective in reducing risk factors of pathological, but it could not improve the long-term survival. The indications of adjuvant therapy after surgery should be reconsidered. Those tumors of diameter 5.5 cm or less response poor to neoadjuvant treatment, and no improvement of survival was found, so direct surgical treatment is suggested for these patients. Radiotherapy is a better choice of preoperative treatment.展开更多
We assessed nutrient characteristics, distributions and fractions within the disturbed and undisturbed sediments at four sampling sites within the mainstream of Haihe River. The river sediments contained mostly sand ...We assessed nutrient characteristics, distributions and fractions within the disturbed and undisturbed sediments at four sampling sites within the mainstream of Haihe River. The river sediments contained mostly sand ( 60%). The fraction of clay was 3%. Total nitrogen (TN) and total phosphorus (TP) concentrations ranged from 729 to 1922 mg/kg and from 692 to 1388 mg/kg, respectively. Nutrient concentrations within the sediments usually decreased with increasing depth. The TN and TP concentrations within the fine sand were higher than for that within silt. Sediment phosphorus fractions were between 2.99% and 3.37% Ex-P (exchangeable phosphorus), 7.89% and 13.71% Fe/Al-P (Fe, Al oxides bound phosphorus), 61.32% and 70.14% Ca-P (calcium-bound phosphorus), and 17.03% and 22.04% Org-P (organic phosphorus). Nitrogen and phosphorus release from sediment could lead to the presence of 21.02 mg N/L and 3.10 mg P/L within the water column. A river restoration project should address the sediment nutrient stock.展开更多
Saline soil has imposed a serious threat on many expressway engineering and agricultural areas.This paper describes the performance of saline soil treatment using electrokinetic remediation technology.Comparison study...Saline soil has imposed a serious threat on many expressway engineering and agricultural areas.This paper describes the performance of saline soil treatment using electrokinetic remediation technology.Comparison study involving sample soil and in situ soil is carried out.Two different electric fields,i.e.,uniform and non-uniform are utilized to promote the migration of inorganic ions contained in the soil toward the electrode area.The effects of different electric field types and potential gradient ion migration rate in soil are investigated.The test result reveals that a uniform electric field of a constant potential gradient of 1 V/cm drives the Cl-through the sample soil at a rate of 1.36 cm/h.Moreover,larger potential gradients could make ions migrate faster,but more electrical energy is consumed in such a way.Compared with uniform electric field,the non-uniform process maintains the soil pH values more effectively and consumes less electrical energy.A desirable result of removing Na+in soil is expected using electrokinetic remediation technology under four-times scaling up of soil volume.展开更多
文摘Objective:The aim of this study was to explore the difference of long-term prognosis of different treatment regimens in patients with stage ⅠB2, ⅡA2 cervical cancer. Methods:From August 1995 to September 2005, radical hysterectomy was chosen as primary treatment regimen for 122 patients (group A), 85 patients underwent radical hysterectomy after effective neoadjuvant therapy (group B), and 98 patients received surgery after ineffective preoperative therapy (group C). All patients received postoperative therapy. Results:A total of 305 patients were analyzed. The maximum diameter of tumor was largest in group B, while the pathological risk factors (cervical infiltration, positive surgical margins) were in the lowest proportion. The 5-year mortality rate and relapse rate of group B were the highest, and the overall survival (OS) and progression-free survival (PFS) were the shortest (P < 0.05). No significant difference of long-term survival was found in group C and group A. No difference was found in the surgical of three groups. Large tumor more than 5.5 cm had higher effective ratio of treatment than those 5.5 cm or less. Patients received effective preoperative radiotherapy had better long-term prognosis than those received chemotherapy or radiochemotherapy. Conclusion:neoadjuvant treatment using for patients with ⅠB2, ⅡA2 cervical cancer is effective in reducing risk factors of pathological, but it could not improve the long-term survival. The indications of adjuvant therapy after surgery should be reconsidered. Those tumors of diameter 5.5 cm or less response poor to neoadjuvant treatment, and no improvement of survival was found, so direct surgical treatment is suggested for these patients. Radiotherapy is a better choice of preoperative treatment.
基金supported by the National Natural Sci- ence Foundation of China (No. 51079068)the Natural Science Foundation of Tianjin (No. 09ZCGYSF00400, 08FDZDSF03402)+1 种基金the National Key-Projects of Water Pollution Control and Prevention (No. 2008ZX07314-005- 001, 2009ZX07209-001)funded by The Royal Society
文摘We assessed nutrient characteristics, distributions and fractions within the disturbed and undisturbed sediments at four sampling sites within the mainstream of Haihe River. The river sediments contained mostly sand ( 60%). The fraction of clay was 3%. Total nitrogen (TN) and total phosphorus (TP) concentrations ranged from 729 to 1922 mg/kg and from 692 to 1388 mg/kg, respectively. Nutrient concentrations within the sediments usually decreased with increasing depth. The TN and TP concentrations within the fine sand were higher than for that within silt. Sediment phosphorus fractions were between 2.99% and 3.37% Ex-P (exchangeable phosphorus), 7.89% and 13.71% Fe/Al-P (Fe, Al oxides bound phosphorus), 61.32% and 70.14% Ca-P (calcium-bound phosphorus), and 17.03% and 22.04% Org-P (organic phosphorus). Nitrogen and phosphorus release from sediment could lead to the presence of 21.02 mg N/L and 3.10 mg P/L within the water column. A river restoration project should address the sediment nutrient stock.
基金The authors express sincere appreciation to anonymous reviewers for their valuable comments on improving this study.The study was jointly supported by grants from the National Natural Science Foundation of China(Grant Nos.51779134,51579142)Program for Changjiang Scholars and Innovative Research Team in University of China(No.IRT13075)Shandong Province Transportation Science and Technology Project(No.2008Y002).
文摘Saline soil has imposed a serious threat on many expressway engineering and agricultural areas.This paper describes the performance of saline soil treatment using electrokinetic remediation technology.Comparison study involving sample soil and in situ soil is carried out.Two different electric fields,i.e.,uniform and non-uniform are utilized to promote the migration of inorganic ions contained in the soil toward the electrode area.The effects of different electric field types and potential gradient ion migration rate in soil are investigated.The test result reveals that a uniform electric field of a constant potential gradient of 1 V/cm drives the Cl-through the sample soil at a rate of 1.36 cm/h.Moreover,larger potential gradients could make ions migrate faster,but more electrical energy is consumed in such a way.Compared with uniform electric field,the non-uniform process maintains the soil pH values more effectively and consumes less electrical energy.A desirable result of removing Na+in soil is expected using electrokinetic remediation technology under four-times scaling up of soil volume.