This study employed multispectral techniques to evaluate fulvic acid(FA)compositional characteristic and elucidate its biodegradation mechanisms during partial nitritation(PN)process.Results showed that FA removal eff...This study employed multispectral techniques to evaluate fulvic acid(FA)compositional characteristic and elucidate its biodegradation mechanisms during partial nitritation(PN)process.Results showed that FA removal efficiency(FRE)decreased from 90.22 to 23.11%when FA concentrations in the reactor were increased from 0 to 162.30 mg/L,and that molecular size,degree of aromatization and humification of the effluent FA macromolecules all increased after treatment.Microbial population analysis indicated that the proliferation of the Comamonas,OLB12 and Thauera exhibit high FA utilization capacity in lower concentrations(<50.59 mg/L),promoting the degradation and removal of macromolecular FA.In addition,the sustained increase in external FA may decrease the abundance of above functional microorganisms,resulting in a rapid drop in FRE.Furthermore,from the genetic perspective,the elevated FA levels restricted carbohydrate(ko00620,ko00010 and ko00020)and nitrogen(HAO,AMO,NIR and NOR)metabolism-related pathways,thereby impeding FA removal and total nitrogen loss associated with N_(2)O emissions.展开更多
This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with sever...This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19.展开更多
With the growing allel programming,nowadays popularity of task-based partask-parallel programming libraries and languages are still with limited support for coordinating parallel tasks.Such limitation forces programme...With the growing allel programming,nowadays popularity of task-based partask-parallel programming libraries and languages are still with limited support for coordinating parallel tasks.Such limitation forces programmers to use additional independent components to coordinate the parallel tasks -the components can be third-party libraries or additional components in the same programming library or language.Moreover,mixing tasks and coordination components increase the difficulty of task-based programming,and blind schedulers for understanding tasks'dependencies. In this paper,we propose a task-based parallel programming library,Function Flow,which coordinates tasks in the purpose of avoiding additional independent coordination components.First,we use dependency expression to represent ubiquitous tasks'termination.The key idea behind dependency expression is to use && for both task's termination and Ⅱ for any task termination,along with the combination of dependency expressions.Second,as runtime support,we use a lightweight representation for dependency expression. Also,we use suspended-task queue to schedule tasks that still have prerequisites to run. Finally,we demonstrate Function Flow's effectiveness in two aspects,case study about implementing popular parallel patterns with FunctionFIow,and performance comparision with state-of-the-art practice,TBB.Our demonstration shows that FunctionFIow can generally coordinate parallel tasks without involving additional components,along with comparable performance with TBB.展开更多
基金supported by the Key Research and Development Project of Shandong (Nos.2021CXGC011202,2020CXGC011404,and 2022CXGC021002)the National Natural Science Foundation of China (No.22276006)。
文摘This study employed multispectral techniques to evaluate fulvic acid(FA)compositional characteristic and elucidate its biodegradation mechanisms during partial nitritation(PN)process.Results showed that FA removal efficiency(FRE)decreased from 90.22 to 23.11%when FA concentrations in the reactor were increased from 0 to 162.30 mg/L,and that molecular size,degree of aromatization and humification of the effluent FA macromolecules all increased after treatment.Microbial population analysis indicated that the proliferation of the Comamonas,OLB12 and Thauera exhibit high FA utilization capacity in lower concentrations(<50.59 mg/L),promoting the degradation and removal of macromolecular FA.In addition,the sustained increase in external FA may decrease the abundance of above functional microorganisms,resulting in a rapid drop in FRE.Furthermore,from the genetic perspective,the elevated FA levels restricted carbohydrate(ko00620,ko00010 and ko00020)and nitrogen(HAO,AMO,NIR and NOR)metabolism-related pathways,thereby impeding FA removal and total nitrogen loss associated with N_(2)O emissions.
基金This study was approved by the institutional ethics board of Wuhan Integrated TCM and Western Medicine Hospital(No.[2020]8)and was registered with chictr.org.cn(ChiCTR2000030719)all procedures followed were in accordance with the ethical standards.
文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19.
基金the National High-Tech Research and Development Program of China (2015AA015303)the National Natural Science Foundation of China (Grant No.61732010).
文摘With the growing allel programming,nowadays popularity of task-based partask-parallel programming libraries and languages are still with limited support for coordinating parallel tasks.Such limitation forces programmers to use additional independent components to coordinate the parallel tasks -the components can be third-party libraries or additional components in the same programming library or language.Moreover,mixing tasks and coordination components increase the difficulty of task-based programming,and blind schedulers for understanding tasks'dependencies. In this paper,we propose a task-based parallel programming library,Function Flow,which coordinates tasks in the purpose of avoiding additional independent coordination components.First,we use dependency expression to represent ubiquitous tasks'termination.The key idea behind dependency expression is to use && for both task's termination and Ⅱ for any task termination,along with the combination of dependency expressions.Second,as runtime support,we use a lightweight representation for dependency expression. Also,we use suspended-task queue to schedule tasks that still have prerequisites to run. Finally,we demonstrate Function Flow's effectiveness in two aspects,case study about implementing popular parallel patterns with FunctionFIow,and performance comparision with state-of-the-art practice,TBB.Our demonstration shows that FunctionFIow can generally coordinate parallel tasks without involving additional components,along with comparable performance with TBB.
