The Efficacy of High-Intensity Focused Ultrasound (HIFU) in Advanced Pancreatic Cancer

OBJECTIVE To observe the efficacy of high-intensity focused ultrasound (HIFU) in the treatment of late-stage pancreatic cancer. METHODS Sixteen patients with advanced pancreatic cancer received HIFU therapy.Evaluation of efficacy was made on the basis of changes in clinical symptoms and variations in the tumor echo and size. RESULTS Clinical symptoms such as pain were significantly alleviated,echo of the tumor was enhanced with B-US and the quality of life such as eating,sleeping and mental status was markedly improved;no serious complications were observed. CONCLUSION The use of HIFU in the treatment of advanced pancreatic cancer is feasible and safe.It is effective in killing the carcinoma cells and alleviating pain.This technique may offer non-invasive therapy for the treatment of patients with late-stage pancreatic cancer.

Effects of a multi-enzyme complex on growth performance,nutrient utilization and bone mineralization of meat duck

Background： Previous studies with broiler have shown dietary supplementation with multi-enzyme complex containing non-starch polysaccharides （NSP） degrading enzymes and phytase is efficient in releasing phosphorus （P）, calcium （Ca）, energy and amino acids from corn-soybean meal diets or corn-sorghum diets, hence compensating considerable levels of nutrients in formulation. Notwithstanding, such potentials have not been well defined in duck nutrition. Giving China being the largest duck producing country, we conducted this study to establish adequate specifications of major nutrients along with multi-enzyme complex to meat duck from day-old to slaughter, focusing on performance, utilization of nutrients and bone mineralization. Five dietary treatments were： Positive control （PC,T1）： the nutrients concentration of diet for 1 to 14 d of age were apparent metabolizable energy（AME） 2,800 kcal/kg, crude protein （CP）1 9.39%, Ca 0.85%, available phosphorus （avP） 0.42%; for 15 to 35 d of age these parameters were AME 2,900 kcal/kg, CP 16.47%,Ca 0.76%,avP 0.38%; Negative control 1（NC1,7-2）, the AME and digestible amino acids （DAA） were reduced by 70 kcal/kg and 2.0%, avP and Ca by 1.0 g/kg from PC diet; Negative control 2（NC2,T4）, the down- spec from PC diet was AME 100 kcal/kg, DAA 2.5%, avP 1.5 g/kg and Ca 1.2 g/kg; The enzyme complex was added at the same dosage （200 mL/1,000 kg） on NC1 （T3） and NC2 （T5） diets. Results： Comparing with the ducks fed on T1, T3 and T5 diets, the birds fed on NC2 diet showed the lowest （P 〈 0.05） body weight （ d 14 and 35）, feed intake （d 35）, tibia ash, Ca and P contents （d 14 and 35）, and the utilization of nutrients （P 〈 0.05）. The supplementation with the enzyme complex to the NC diets restored growth rate, utilization of nutrients and bone mineralization to the level of the PC diet, and increased AME by 60 kcal/kg and 117 kcal/kg, respectively for the NC1 and NC2 diets. Conclusion： These results suggest that down-spec AME by 100 kcal/kg, DAA by 2.5%, avP by 1.5 g/kg and Ca by 1.2 g/kg caused detrimental effects on duck performance compared with those fed on the PC diet, and these performance losses can be compensated by the addition of the multiple-enzyme complex.

Land Use Zoning in Three-Gorge Reservoir Region:A Case Study of Fengdu County in Chongqing Municipality

Taking Fengdu County in Three-Gorge Reservoir region as an example,this paper applies the dynamic clustering analysis model, and divides land resource utilization of Fengdu County into three zones: Yangtze River valley economic zone,low mountains and hills agricultural zone,and low and middle agricultural,forestry and animal husbandry zone. It also analyzes current situation and existing problems in the land utilization of every zone,and finally puts forward corresponding recommendations.

声学三维量子霍尔态的观测

Quantum Hall effect,the quantized transport phenomenon of electrons under strong magnetic fields,remains one of the hottest research topics in condensed matter physics since its discovery in 2D electronic systems.Recently,as a great advance in the research of quantum Hall effects,the quantum Hall effect in 3D systems,despite its big challenge,has been achieved in the bulk ZrTe_(5)and Cd_(3)As_(2)materials.Interestingly,Cd_(3)As_(2)is a Weyl semimetal,and quantum Hall effect is hosted by the Fermi arc states on opposite surfaces via the Weyl nodes of the bulk,and induced by the unique edge states on the boundaries of the opposite surfaces.However,such intriguing edge state distribution has not yet been experimentally observed.Here,we aim to reveal experimentally the unusual edge states of Fermi arcs in acoustic Weyl system with the aid of pseudo-magnetic field.Benefiting from the macroscopic nature of acoustic crystals,the pseudo-magnetic field is introduced by elaborately designed the gradient onsite energy,and the edge states of Fermi arcs on the boundaries of the opposite surfaces are unambiguously demonstrated in experiments.Our system serves as an ideal and highly tunable platform to explore the Hall physics in 3D system,and has the potential in the application of new acoustic devices.

Brillouin Klein space and half-turn space in three-dimensional acoustic crystals

The Bloch band theory and Brillouin zone(BZ)that characterize wave-like behaviors in periodic mediums are two cornerstones of contemporary physics,ranging from condensed matter to topological physics.Recent theoretical breakthrough revealed that,under the projective symmetry algebra enforced by artificial gauge fields,the usual two-dimensional(2D)BZ(orientable Brillouin two-torus)can be fundamentally modified to a non-orientable Brillouin Klein bottle with radically distinct manifold topology.However,the physical consequence of artificial gauge fields on the more general three-dimensional(3D)BZ(orientable Brillouin three-torus)was so far missing.Here,we theoretically discovered and experimentally observed that the fundamental domain and topology of the usual 3D BZ can be reduced to a non-orientable Brillouin Klein space or an orientable Brillouin half-turn space in a 3D acoustic crystal with artificial gauge fields.We experimentally identify peculiar 3D momentum-space non-symmorphic screw rotation and glide reflection symmetries in the measured band structures.Moreover,we experimentally demonstrate a novel stacked weak Klein bottle insulator featuring a nonzero Z2 topological invariant and self-collimated topological surface states at two opposite surfaces related by a nonlocal twist,radically distinct from all previous 3D topological insulators.Our discovery not only fundamentally modifies the fundamental domain and topology of 3D BZ,but also opens the door towards a wealth of previously overlooked momentum-space multidimensional manifold topologies and novel gaugesymmetry-enriched topological physics and robust acoustic wave manipulations beyond the existing paradigms.

谷边缘态作为连续域中的束缚态

Bound states in the continuum(BICs) are spatially localized states with energy embedded in the continuum spectrum of extended states. The combination of BICs physics and nontrivial band topology theory givs rise to topological BICs, which are robust against disorders and meanwhile, the merit of conventional BICs is attracting wide attention recently. Here, we report valley edge states as topological BICs, which appear at the domain wall between two distinct valley topological phases. The robustness of such BICs is demonstrated. The simulations and experiments show great agreement. Our findings of valley related topological BICs shed light on both BICs and valley physics, and may foster innovative applications of topological acoustic devices.

Western diet induces GSDME-mediated epithelial pyroptosis through the DCA-S1PR2 pathway to disrupt the intestinal epithelial barrier

Inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic and refractory inflammatory bowel disorder[1].The incidence of IBD is greater in Western countries than in Asia and the Middle East and significantly increased in previously less prevalent countries with an increase in Western diet(WD)adoption in these countries,suggesting that WD may be a potential risk factor for the development of IBD[2,3].

数字化转型与企业高质量创新——基于突破式创新视角的分析与论证

在我国面临加快形成新质生产力的要求与努力突破科技封锁的需要这种双重压力下,探究如何提升企业的创新质量既是发展需要也是现实要求。本文从突破式创新视角出发理解高质量创新,引入了一个全新的衡量企业突破式创新水平的方法,并运用2010—2021年我国A股上市公司数据实证探讨了数字化转型对企业高质量创新的影响。研究发现:首先,数字化转型能够显著地提升企业突破式创新水平,并且这种影响具有时间上的持续性,该结果在考虑内生性问题以及进行了一系列稳健性检验后依然成立;其次,数字化转型能够通过降低代理成本、优化人力资本结构以及促进企业内部资源整合能力这三条途径来提升创新质量;最后,数字化转型对企业突破式创新的促进效应在国企、资本技术密集型企业以及中小型企业内更加明显。本文的研究进一步拓展对于数字化转型与企业创新相关领域的研究,并为我国企业数字化转型提供了有益借鉴。

Acoustic higher-order topology derived from first-order with built-in Zeeman-like fields

Higher-order topological insulators(HOTIs),with topological corner or hinge states,have emerged as a thriving topic in the field of topological physics.However,few connections have been found for HOTIs with well-explored first-order topological insulators.Recently a proposal asserted that a significant bridge can be established between the HOTIs and Z2 topological insulators.When subjected to an inplane Zeeman field,corner states,the signature of the HOTIs,can be induced in a Z2 topological insulator.Such Zeeman fields can be produced,for example,by the ferromagnetic proximity effect or magnetic atom doping,which drastically increases the experimental complexity.Here,we show that a phononic crystal,designed as a bilayer of coupled acoustic cavities,exactly hosts the Kane-Mele model with built-in in-plane Zeeman fields.The helical edge states along the zigzag edges are gapped,and the corner states,localized spatially at the corners of the samples,appear in the gap.This verifies the Zeeman field induced higher-order topology.We further demonstrate the intriguing contrast properties of the corner states at the outer and inner corners in a hexagonal ring-shaped sample.

连续介质中的弹性波拓扑材料

弹性波具有广泛的应用,如信号处理、传感和通信等.高效地控制弹性波的传播具有重要的应用价值.受到电子体系中各种拓扑现象的启发,弹性波拓扑态及其鲁棒性传输引起了人们的广泛关注.本文综述了近年来弹性波拓扑的最新研究进展,包括弹性波量子自旋霍尔效应、能谷霍尔效应、外尔半金属、高阶拓扑态,以及其他拓扑效应.最后,我们对弹性波拓扑效应的研究作了简要的展望:三维弹性波拓扑材料及其丰富拓扑输运现象还有待实验验证;弹性波体系中的非厄米拓扑物理研究还需要进一步的探索;由于微纳结构材料具有很强的非线性响应,弹性波是研究拓扑非线性特性的理想平台;除了被动单元,主动单元的引入有望实现可调控的多功能弹性波器件.

Author correction to‘Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy'[Acta Pharm Sin B 13(2023)1303-1317]

The authors regret that there is an error in the article Fig.4G due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading.Although it does not affect the conclusion,it is an obvious error.The authors have now modified as below.The authors apologize for any inconvenience caused to the journal and readers.

Signal-on bimodal sensing glucose based on enzyme product-etching MnO_(2)nanosheets for detachment of MoS_(2)quantum dots

The sensitive and rapid detection of blood glucose is very important for monitoring and managing diabetes.Herein,a fluorescent/magnetic bimodal sensing strategy is proposed for glucose detection using a multifunction-responsive nanocomposite(MoS_(2)QDs-MnO_(2)NS).MoS_(2)QDs act as fluorescent probes,and MnO_(2)nanosheets are used as both quenchers and recognizers in this sensing platform.In the presence of glucose-mediated enzyme product(H_(2)O_(2)),MnO_(2)nanosheet is etched,thus releasing MoS_(2)QDs and Mn^(2+)ions,which causes the significantly enhancement of fluorescent and magnetic signals.Furthermore,MoS_(2)QDs-MnO_(2)NS-based fluorescent test paper is constructed for H_(2)O_(2)sensing with the naked eyes.Under optimal conditions,the dual linear ranges of 20-300μmol/L and 40-250μmol/L toward glucose detection are obtained for the fluorescent and magnetic mode,respectively.Furthermore,this bimodal assay exhibits good reproducibility and acceptable accuracy in glucose detection of clinical samples,demonstrating great versatility and flexibility of multifunctional probes in glucose detection.

Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH-sensitive chemo-phototherapy

In situ and real-time monitoring of responsive drug release is critical for the assessment of pharmacodynamics in chemotherapy.In this study,a novel pH-responsive nanosystem is proposed for real-time monitoring of drug release and chemo-phototherapy by surface-enhanced Raman spectroscopy(SERS).The Fe3O4@Au@Ag nanoparticles(NPs)deposited graphene oxide(GO)nanocomposites with a high SERS activity and stability are synthesized and labeled with a Raman reporter 4-mercaptophenylboronic acid(4-MPBA)to form SERS probes(GO-Fe3O4@Au@Ag-MPBA).Furthermore,doxorubicin(DOX)is attached to SERS probes through a pH-responsive linker boronic ester(GO-Fe3O4@Au@Ag-MPBA-DOX),accompanying the 4-MPBA signal change in SERS.After the entry into tumor,the breakage of boronic ester in the acidic environment gives rise to the release of DOX and the recovery of 4-MPBA SERS signal.Thus,the DOX dynamic release can be monitored by the real-time changes of 4-MPBA SERS spectra.Additionally,the strong T2 magnetic resonance(MR)signal and NIR photothermal transduction efficiency of the nanocomposites make it available for MR imaging and photothermal therapy(PTT).Altogether,this GO-Fe3O4@Au@Ag-MPBA-DOX can simultaneously fulfill the synergistic combination of cancer cell targeting,pH-sensitive drug release,SERS-traceable detection and MR imaging,endowing it great potential for SERS/MR imaging-guided efficient chemo-phototherapy on cancer treatment.

Acoustic spin-1 Weyl semimetal

The study of topological semimetals hosting spin-1 Weyl points(WPs)beyond Dirac points and WPs has attracted a great deal of attention.However,a spin-1 Weyl semimetal that exclusively possesses spin-1 WPs in a clean frequency window without being shadowed by any other nodal points is yet to be discovered.This study reports a spin-1 Weyl semimetal in a phononic crystal.Its spin-1 WPs are touched by two linear dispersions and an additional flat band and carry monopole charges(-2,0,2)or(2,0,-2)for the three bands from the bottom to the top.They result in double Fermi arcs,which occur between the first and second bands,as well as between the second and third bands.Further robust propagation is observed against the multiple joints and topological negative refraction of the acoustic surface arc wave.The results of this study create the basis for the exploration of the unusual properties of spin-1 Weyl physics on a macroscopic scale.