A thioester-functionalized triphenylamine hole-transporting molecule(TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surface w...A thioester-functionalized triphenylamine hole-transporting molecule(TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surface was characterized by aqueous contact angle, ellipsometer, atomic force microscopy, X-ray photoelectron spectroscopy, and ultraviolet photoelectron spectrometer to substantiate the formation of compact and pinhole-free monolayers. The modified organic light emitting diode device [indium-tin oxide/Au(5 nm)/self-assembled monolayers(SAM)/TPD(50 nm)/Alq_3(40 nm)/TPBI(15 nm)/LiF(1 nm)/Al(100 nm)] showed a luminance of 7303.90 cd/m^2 and a current efficiency of 8.49 cd/A with 1.78 and 2.29-fold increase, respectively, compared to the control device without SAM. The improvements were attributed to the enhanced compatibility of the organic–inorganic interface, matched energy level by introduction of an energy mediating step and superior hole-injection property of SAM molecules.展开更多
In this study, we applied a novel, mild, and convenient synthetic method involving the oxidative cyclization of 1-(pyrazin-2-yl)guanidine derivatives to produce [1,2,4]triazolo[4,3-a ]pyrazin-3-amines. We optimized th...In this study, we applied a novel, mild, and convenient synthetic method involving the oxidative cyclization of 1-(pyrazin-2-yl)guanidine derivatives to produce [1,2,4]triazolo[4,3-a ]pyrazin-3-amines. We optimized the reaction procedure to easily obtain 5-chloro-[1,2,4]triazolo[4,3-a ]pyrazin-3-amine. Various types of halogenated pyrazines can successfully undergo this process. We synthesized a series of 1-(pyrazin-2-yl)guanidines and [1,2,4]triazolo[4,3-a ]pyrazin-3-amines, and then elucidated their structures based on their ~1H-NMR, ^(13)C-NMR, ESI-HRMS, and nuclear Overhauser effect spectra.展开更多
The aim of this paper was to develop a cataplasma matrix that can be applicable to both watersoluble and liposoluble drugs.The gellan gum and konjaku were employed as the scaffold materials of the matrix.With polyacry...The aim of this paper was to develop a cataplasma matrix that can be applicable to both watersoluble and liposoluble drugs.The gellan gum and konjaku were employed as the scaffold materials of the matrix.With polyacrylic acid sodium and oligosaccharides as tacktifier,the formula of the cataplasma matrix was optimized in the orthogonal method as:gellan gum 0.4 g,xanthan gum 0.03 g,konjac glue 0.1 g,glycerin 4 g,Gluco-Adhesive T(GAT)6 g,Gluco-Adhesive E(GAE)6 g,polyacrylic acid sodium 0.22 g,and sorbitol 3 g.The 180°peel strength,the tensile strength and the elongation at break was 3.043 N,0.275 MPa and 91.05%,respectively.Furthermore,the drug-compatibilities of the matrix were investigated with baicalin,berberine and curcumin,which were used as the models of hydrophilic,poor-water-soluble and hydrophobic ingredients.The drug contents could reach 4.12%,2.42%and 3.75%,while the in vitro release rate were measured as,361.79,55.85 and 104.41μg·cm^(-2)·h^(-1)for baicalin,berberine and curcumin,respectively.These results indicated that the obtained matrix had good drug-compatibility and drug-release properties for different ingredients.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21506151,21576195 and 21776207)
文摘A thioester-functionalized triphenylamine hole-transporting molecule(TPD-SAc) was synthesized and self-assembled to form a monolayer on an ultra-thin Au film supported on indium-tin oxide glass. The modified surface was characterized by aqueous contact angle, ellipsometer, atomic force microscopy, X-ray photoelectron spectroscopy, and ultraviolet photoelectron spectrometer to substantiate the formation of compact and pinhole-free monolayers. The modified organic light emitting diode device [indium-tin oxide/Au(5 nm)/self-assembled monolayers(SAM)/TPD(50 nm)/Alq_3(40 nm)/TPBI(15 nm)/LiF(1 nm)/Al(100 nm)] showed a luminance of 7303.90 cd/m^2 and a current efficiency of 8.49 cd/A with 1.78 and 2.29-fold increase, respectively, compared to the control device without SAM. The improvements were attributed to the enhanced compatibility of the organic–inorganic interface, matched energy level by introduction of an energy mediating step and superior hole-injection property of SAM molecules.
基金supported by the National Nature Science Foundation of China(Nos.21576195 and 21776207)
文摘In this study, we applied a novel, mild, and convenient synthetic method involving the oxidative cyclization of 1-(pyrazin-2-yl)guanidine derivatives to produce [1,2,4]triazolo[4,3-a ]pyrazin-3-amines. We optimized the reaction procedure to easily obtain 5-chloro-[1,2,4]triazolo[4,3-a ]pyrazin-3-amine. Various types of halogenated pyrazines can successfully undergo this process. We synthesized a series of 1-(pyrazin-2-yl)guanidines and [1,2,4]triazolo[4,3-a ]pyrazin-3-amines, and then elucidated their structures based on their ~1H-NMR, ^(13)C-NMR, ESI-HRMS, and nuclear Overhauser effect spectra.
基金the National Natural Science Foundation of China for the financial support(Grant No.20606024).
文摘The aim of this paper was to develop a cataplasma matrix that can be applicable to both watersoluble and liposoluble drugs.The gellan gum and konjaku were employed as the scaffold materials of the matrix.With polyacrylic acid sodium and oligosaccharides as tacktifier,the formula of the cataplasma matrix was optimized in the orthogonal method as:gellan gum 0.4 g,xanthan gum 0.03 g,konjac glue 0.1 g,glycerin 4 g,Gluco-Adhesive T(GAT)6 g,Gluco-Adhesive E(GAE)6 g,polyacrylic acid sodium 0.22 g,and sorbitol 3 g.The 180°peel strength,the tensile strength and the elongation at break was 3.043 N,0.275 MPa and 91.05%,respectively.Furthermore,the drug-compatibilities of the matrix were investigated with baicalin,berberine and curcumin,which were used as the models of hydrophilic,poor-water-soluble and hydrophobic ingredients.The drug contents could reach 4.12%,2.42%and 3.75%,while the in vitro release rate were measured as,361.79,55.85 and 104.41μg·cm^(-2)·h^(-1)for baicalin,berberine and curcumin,respectively.These results indicated that the obtained matrix had good drug-compatibility and drug-release properties for different ingredients.
