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Circular RNA and its potential as prostate cancer biomarkers 被引量:1
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作者 Dwayne Tucker Wei Zheng +1 位作者 Da-Hong Zhang xuesen dong 《World Journal of Clinical Oncology》 CAS 2020年第8期563-572,共10页
Advancing knowledge of the transcriptome has revealed that circular RNAs(circRNAs)are widely expressed and evolutionarily conserved molecules that may serve relevant biological roles.More interesting is the accumulati... Advancing knowledge of the transcriptome has revealed that circular RNAs(circRNAs)are widely expressed and evolutionarily conserved molecules that may serve relevant biological roles.More interesting is the accumulating evidence which demonstrates the implication of circRNAs in diseases,especially cancers.This revelation has helped to form the rationale for many studies exploring their utility as clinical biomarkers.CircRNAs are highly stable due to their unique structures,exhibit some tissue specificity,and are enriched in exosomes,which facilitate their detection in a range of body fluids.These properties make circRNAs ideal candidates for biomarker development in many diseases.This review will outline the discovery,biogenesis,and proposed functions of circRNAs. 展开更多
关键词 Circular RNA RNA splicing Prostate cancer BIOMARKER Cell-free RNA
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