A catalytic,enantioselective spirocyclization of formanilides or formylindolines and enamides has been developed herein.The reaction proceeds through a sequential iridium-catalyzed hydrosilylation of tertiary formanil...A catalytic,enantioselective spirocyclization of formanilides or formylindolines and enamides has been developed herein.The reaction proceeds through a sequential iridium-catalyzed hydrosilylation of tertiary formanilides and a chiral phosphoric acid-catalyzed formal cycloaddition of exocyclic enamides,thus providing straightforward access to a diverse array of enantioenriched azaspirocycles under mild conditions.展开更多
基金the National Natural Science Foundation of China(grant nos.21971204 and 21622203)the Innovation Capability Support Program of Shaanxi Province(grant no.2020TD-022).
文摘A catalytic,enantioselective spirocyclization of formanilides or formylindolines and enamides has been developed herein.The reaction proceeds through a sequential iridium-catalyzed hydrosilylation of tertiary formanilides and a chiral phosphoric acid-catalyzed formal cycloaddition of exocyclic enamides,thus providing straightforward access to a diverse array of enantioenriched azaspirocycles under mild conditions.
