Objective:To study the relationship between DEXA bone mineral density measurement results and serum cytokines as well as insulin resistance in patients with type 2 diabetes mellitus and osteoporosis.Methods:Patients n...Objective:To study the relationship between DEXA bone mineral density measurement results and serum cytokines as well as insulin resistance in patients with type 2 diabetes mellitus and osteoporosis.Methods:Patients newly diagnosed with type 2 diabetes were selected and divided into normal bone mass group, osteopenia group and osteoporosis group according to the DEXA femoral neck bone mineral density measurement results, the bone mineral density of all parts in of three groups of patients were measured, and serum was collected to determine the levels of bone metabolism indexes, cytokines and insulin.Results:Femoral trochanter, Ward's area as well as the 2-4th lumbar vertebra bone mineral density values of osteopenia group and osteoporosis group were significantly lower than those of normal bone mass group, and the femoral trochanter, Ward's area as well as the 2-4th lumbar vertebra bone mineral density values of osteoporosis group were significantly lower than those of osteopenia group;serum N-MID, PINP and BGP levels of osteopenia group and osteoporosis group were significantly lower than those of normal bone mass group whileβ-CTX, TRACP5b, Ins, Chemerin, TNF-α, IL-1β and MCP-1 levels were significantly higher than those of normal bone mass group;serum N-MID, PINP and BGP levels of osteoporosis group were significantly lower than those of osteopenia group whileβ-CTX, TRACP5b, Ins, Chemerin, TNF-α, IL-1β and MCP-1 levels were significantly higher than those of osteopenia group;serum Ins, Chemerin, TNF-α, IL-1β and MCP-1 levels were negatively correlated with N-MID, PIN and BGP levels, and positively correlated with serumβ-CTX and TRACP5b levels.Conclusion:Excessively synthesized inflammatory factors and compensatory hyperinsulinemia in patients with type 2 diabetes mellitus and osteoporosis can promote bone resorption and inhibit bone formation, thus resulting in the osteopenia in multiple areas of the body.展开更多
文摘Objective:To study the relationship between DEXA bone mineral density measurement results and serum cytokines as well as insulin resistance in patients with type 2 diabetes mellitus and osteoporosis.Methods:Patients newly diagnosed with type 2 diabetes were selected and divided into normal bone mass group, osteopenia group and osteoporosis group according to the DEXA femoral neck bone mineral density measurement results, the bone mineral density of all parts in of three groups of patients were measured, and serum was collected to determine the levels of bone metabolism indexes, cytokines and insulin.Results:Femoral trochanter, Ward's area as well as the 2-4th lumbar vertebra bone mineral density values of osteopenia group and osteoporosis group were significantly lower than those of normal bone mass group, and the femoral trochanter, Ward's area as well as the 2-4th lumbar vertebra bone mineral density values of osteoporosis group were significantly lower than those of osteopenia group;serum N-MID, PINP and BGP levels of osteopenia group and osteoporosis group were significantly lower than those of normal bone mass group whileβ-CTX, TRACP5b, Ins, Chemerin, TNF-α, IL-1β and MCP-1 levels were significantly higher than those of normal bone mass group;serum N-MID, PINP and BGP levels of osteoporosis group were significantly lower than those of osteopenia group whileβ-CTX, TRACP5b, Ins, Chemerin, TNF-α, IL-1β and MCP-1 levels were significantly higher than those of osteopenia group;serum Ins, Chemerin, TNF-α, IL-1β and MCP-1 levels were negatively correlated with N-MID, PIN and BGP levels, and positively correlated with serumβ-CTX and TRACP5b levels.Conclusion:Excessively synthesized inflammatory factors and compensatory hyperinsulinemia in patients with type 2 diabetes mellitus and osteoporosis can promote bone resorption and inhibit bone formation, thus resulting in the osteopenia in multiple areas of the body.
