The compositional variability of ocean island basalts(OIBs)is thought to reflect partial melting of a lithologicallyheterogeneous mantle source dominated by either pyroxenite or peridotite.The Pohnpei Island in Micron...The compositional variability of ocean island basalts(OIBs)is thought to reflect partial melting of a lithologicallyheterogeneous mantle source dominated by either pyroxenite or peridotite.The Pohnpei Island in Micronesia,which is associated with the Caroline hotspot,is suggested to have been generated from partial melting of a pyroxenite-rich mantle.To examine this hypothesis,we present new major-and trace-element compositions of olivine phenocrysts in basalts from the island.The olivines exhibit large systematic inter-and intra-crystalline compositional variability.In Sample DS1,olivines record compositional zonation,in which cores have relatively high Fo(77–85),Ni(550×10^(-6 )–2392×10^(-6 )),and Fe/Mn ratios(66–82),whereas rims have lower Fo(71–78),Ni(526×10^(-6 )–1537×10^(-6 )),and Fe/Mn ratios(51–62).By contrast,olivines within other samples preserve no clear compositional zonation,exhibiting similar or slightly lower Fo values(66–78),Ni contents(401×10^(-6 )–1268×10^(-6 )),and Fe/Mn ratios(53–69)as the rims of zoned crystals.The distinct chemical contrast between the two different types of olivine suggests they formed in magma chambers at different depths.Analysis using forward petrological modeling and multi-element indicators(Fe/Mn,Zn/Fe,FC3MS(FeO^(T)/CaO-(3×MgO/SiO^(2))),Mn/Zn,and Ni/(Mg/Fe))of whole-rock samples and high-Fo olivines is inconsistent with a pyroxenite-rich mantle source.We suggest these inconsistencies reflect an influence on the partition coefficients of Ni and Mn between olivine and liquid during melting at variable pressures and temperatures.In addition,magma recharge and mixing within the magmatic plumbing system can change the composition of olivine.We suggest that identification of the mantle source of OIBs in volcanic islands such as the Pohnpei Island using olivine geochemistry should be treated with caution.展开更多
Percutaneous coronary intervention is a well-established technique used to treat coronary artery disease,but the risk of coronary artery in-stent restenosis following percutaneous coronary intervention is still high.P...Percutaneous coronary intervention is a well-established technique used to treat coronary artery disease,but the risk of coronary artery in-stent restenosis following percutaneous coronary intervention is still high.Previous studies revealed that high mobility group protein B1(HMGB1)plays a critical role in neointima formation.In this study,we aimed to investigate the role of glycyrrhizic acid(GA),an HMGB1 inhibitor,in the process of neointima formation and the potential mechanisms.We investigated the role of GA in neointima formation through an iliac artery balloon injury model in rabbits.Proliferation,migration,and phenotype transformation of human vascular smooth muscle cells(VSMCs)were observed.Besides,infl ammation and receptor for advanced glycosylation end products(RAGE)signaling pathways were studied.The results indicate that GA attenuated neointima formation and downregulated HMGB1 expression in injured artery in rabbits.HMGB1 promoted proliferation,migration,and phenotype transformation through the activation of RAGE signaling pathways in VSMCs,and blockade of HMGB1 by GA(1,10,and 100μM)could attenuate those processes and reduce proliferation of human VSMCs.In conclusion,the HMGB1 inhibitor GA might be useful to treat proliferative vascular diseases by downregulating RAGE signaling pathways.Our results indicate a new and promising therapeutic agent for restenosis.展开更多
Background:Myxomas are the most common primary cardiac tumors.Angiographically detectable neovascularity(ADN)of myxoma is increasingly being reported as a result of the use of coronary angiography(CAG)to detect corona...Background:Myxomas are the most common primary cardiac tumors.Angiographically detectable neovascularity(ADN)of myxoma is increasingly being reported as a result of the use of coronary angiography(CAG)to detect coronary artery disease.However,the clinical signifi cance of these fi ndings is not fully understood.Methods:We enrolled 59 patients with cardiac myxoma who also underwent CAG between January 2013 and October 2018.Patients were followed up for a mean of 28.9 months(range 1-69 months).The clinical features,echocardiography measurements,pathological examination fi ndings,CAG results,and outcomes during follow-up were compared between patients with ADN and patients without ADN.Results:ADN was found in 25 patients(42.4%).The arteries feeding the ADN included the right coronary artery(n=15),the left circumfl ex coronary artery(n=7),and both arteries(n=3).The patients with ADN had a higher proportion of eosinophils(3.2%vs.2.2%,P=0.03)and higher low-density lipoprotein cholesterol level(2.7 mmol/L vs.2.2 mmol/L,P=0.02).Myxoma pedicles were more likely to be located in the interatrial septum in patients with ADN(96%vs.73.5%,P=0.02).No signifi cant correlation was observed between the groups in clinical manifestations,atrial arrhythmia,myxoma size,cardiac chamber size,left ventricular ejection fraction,and the prevalence of complication with coronary artery disease[16%in the ADN group(n=4)vs.20.6%in the non-ADN group(n=7),P=0.66].However,patients with ADN tended to have a lower incidence of major adverse cardiac and cerebrovascular events on long-term follow-up(0%vs.14.7%,P=0.07).Conclusion:CAG-detected ADN in patients with cardiac myxoma is associated with a borderline lower rate of major adverse cardiac and cerebrovascular events.展开更多
Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of ...Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of the new countryside construction data,we give an overview of the database design based on ArcSDE and SQL Server,and elaborate the association between data classification organization,database conceptual design,logical design,spatial data,and thematic attribute data.Finally,taking the provincial new countryside demonstration zone in Yanjiang District of Sichuan Province for example,we build the new countryside construction database.展开更多
Excitation wavelength dependent(Ex-De) luminescent materials have attracted intense attention due to their great potential in multicolor bioimaging,dynamic anti-counterfeiting,and light emitting devices.However,it rem...Excitation wavelength dependent(Ex-De) luminescent materials have attracted intense attention due to their great potential in multicolor bioimaging,dynamic anti-counterfeiting,and light emitting devices.However,it remains a formidable challenge to construct an Ex-De luminescent biomaterial with green starting materials,excellent biocompatibility,good water solubility,and multiple color emission for dynamic cell imaging.In this work,nanocomposites based on the facile self-assembly strategy of bovine serum albumin(BSA) and Au(Ⅰ)-complex are rationally designed and synthesized to simultaneously present Ex-De fluorescence(429–516 nm) and decent phosphorescence(~615 nm) in a dilute aqueous solution.Combinatory analyses of spectroscopic and microscopic results reveal that the luminescent mechanism of Au(Ⅰ)-BSA nanocomposites is cluster-induced Ex-De fluorescence and metal-to-ligand charge transition(MLCT) based phosphorescence.Importantly,based on the excellent biocompatibility,water-solubility and color-tunable emission over the entire visible region(360–800 nm),the Au(Ⅰ)-BSA nanocomposites are successfully used for cell imaging with multiple and switchable colors on demand.What is more,the solid tablets of Au(Ⅰ)-BSA nanoparticles showed pressure-responsive luminescence and decent room temperature phosphorescence.This work provides an assembling-induced emission strategy for the design of water-soluble,non-cytotoxic,and color-tunable luminescent biomaterials based on the composite of protein and Au nanoparticles.展开更多
In nanoscience, molecular switches have played a significant role to deliver different control abilities to practical functions,whereas high-contrast luminescence switchable manipulation at nanoscale is still limited....In nanoscience, molecular switches have played a significant role to deliver different control abilities to practical functions,whereas high-contrast luminescence switchable manipulation at nanoscale is still limited. Since the tuning for emission behavior with high contrast ratio strongly connects to numerous visualized sensing and optoelectronic applications, we here report that autonomous p H control can be enrolled to address a high-contrast molecular emission change at the nanoaggregated level, for gaining a flicker luminescence performance in aqueous media. Employing a BODIPY contained dynamic covalent dye, we find its luminescent signal and nanoaggregate size can be spontaneously adjusted in water. On this basis, high-contrast luminescence switching of the material can be achieved upon the alternate introduction of base and acid into the aggregation state. Such a behavior can be attributed to a p H triggered photo-induced electron transfer regulation process. The dye aggregates can be well endocytosed for bioimaging and its luminescent variation can be autonomously displayed as a flicker effect. These results provide new visions for the design and development of smart materials with a dynamic luminescence behavior.展开更多
Organic thermally activated delayed fluorescence(TADF)emitters have attracted increasing concerns,owing to their atypical photophysical features that can pave the way to the innovative engineering applications.As cutt...Organic thermally activated delayed fluorescence(TADF)emitters have attracted increasing concerns,owing to their atypical photophysical features that can pave the way to the innovative engineering applications.As cutting-edge type of luminescent molecules,however,most of them only exert a single-wavelength emission from the lowest excited state,according to Kasha’s rule.To develop their potential applications in multicolor luminescence and multi-functional luminescent probes for biological imaging,researchers have begun to turn their attention to design organic TADF molecules with dual-emission characteristics,by employing an additional fluorescence,phosphorescence,or TADF signal within a single-component system.We herein summarized the design principles as well as the luminescence mechanism of organic donor-acceptor TADF compounds with dual-emission characteristics,the superiority of which can cover unique material applications in modern luminescencerelated fields.展开更多
基金The Resources and Environment Projects of China Ocean Mineral R&D Association under contract No.DY135-E2-2-01the Natural Science Foundation of Shandong Province under contract No.ZR2020QD076
文摘The compositional variability of ocean island basalts(OIBs)is thought to reflect partial melting of a lithologicallyheterogeneous mantle source dominated by either pyroxenite or peridotite.The Pohnpei Island in Micronesia,which is associated with the Caroline hotspot,is suggested to have been generated from partial melting of a pyroxenite-rich mantle.To examine this hypothesis,we present new major-and trace-element compositions of olivine phenocrysts in basalts from the island.The olivines exhibit large systematic inter-and intra-crystalline compositional variability.In Sample DS1,olivines record compositional zonation,in which cores have relatively high Fo(77–85),Ni(550×10^(-6 )–2392×10^(-6 )),and Fe/Mn ratios(66–82),whereas rims have lower Fo(71–78),Ni(526×10^(-6 )–1537×10^(-6 )),and Fe/Mn ratios(51–62).By contrast,olivines within other samples preserve no clear compositional zonation,exhibiting similar or slightly lower Fo values(66–78),Ni contents(401×10^(-6 )–1268×10^(-6 )),and Fe/Mn ratios(53–69)as the rims of zoned crystals.The distinct chemical contrast between the two different types of olivine suggests they formed in magma chambers at different depths.Analysis using forward petrological modeling and multi-element indicators(Fe/Mn,Zn/Fe,FC3MS(FeO^(T)/CaO-(3×MgO/SiO^(2))),Mn/Zn,and Ni/(Mg/Fe))of whole-rock samples and high-Fo olivines is inconsistent with a pyroxenite-rich mantle source.We suggest these inconsistencies reflect an influence on the partition coefficients of Ni and Mn between olivine and liquid during melting at variable pressures and temperatures.In addition,magma recharge and mixing within the magmatic plumbing system can change the composition of olivine.We suggest that identification of the mantle source of OIBs in volcanic islands such as the Pohnpei Island using olivine geochemistry should be treated with caution.
基金National Natural Science Foundation of China project 81600248(to Z.Zhu)Hunan Provincial Natural Science Foundation of China project 2018JJ3744(to Z.Zhu).
文摘Percutaneous coronary intervention is a well-established technique used to treat coronary artery disease,but the risk of coronary artery in-stent restenosis following percutaneous coronary intervention is still high.Previous studies revealed that high mobility group protein B1(HMGB1)plays a critical role in neointima formation.In this study,we aimed to investigate the role of glycyrrhizic acid(GA),an HMGB1 inhibitor,in the process of neointima formation and the potential mechanisms.We investigated the role of GA in neointima formation through an iliac artery balloon injury model in rabbits.Proliferation,migration,and phenotype transformation of human vascular smooth muscle cells(VSMCs)were observed.Besides,infl ammation and receptor for advanced glycosylation end products(RAGE)signaling pathways were studied.The results indicate that GA attenuated neointima formation and downregulated HMGB1 expression in injured artery in rabbits.HMGB1 promoted proliferation,migration,and phenotype transformation through the activation of RAGE signaling pathways in VSMCs,and blockade of HMGB1 by GA(1,10,and 100μM)could attenuate those processes and reduce proliferation of human VSMCs.In conclusion,the HMGB1 inhibitor GA might be useful to treat proliferative vascular diseases by downregulating RAGE signaling pathways.Our results indicate a new and promising therapeutic agent for restenosis.
文摘Background:Myxomas are the most common primary cardiac tumors.Angiographically detectable neovascularity(ADN)of myxoma is increasingly being reported as a result of the use of coronary angiography(CAG)to detect coronary artery disease.However,the clinical signifi cance of these fi ndings is not fully understood.Methods:We enrolled 59 patients with cardiac myxoma who also underwent CAG between January 2013 and October 2018.Patients were followed up for a mean of 28.9 months(range 1-69 months).The clinical features,echocardiography measurements,pathological examination fi ndings,CAG results,and outcomes during follow-up were compared between patients with ADN and patients without ADN.Results:ADN was found in 25 patients(42.4%).The arteries feeding the ADN included the right coronary artery(n=15),the left circumfl ex coronary artery(n=7),and both arteries(n=3).The patients with ADN had a higher proportion of eosinophils(3.2%vs.2.2%,P=0.03)and higher low-density lipoprotein cholesterol level(2.7 mmol/L vs.2.2 mmol/L,P=0.02).Myxoma pedicles were more likely to be located in the interatrial septum in patients with ADN(96%vs.73.5%,P=0.02).No signifi cant correlation was observed between the groups in clinical manifestations,atrial arrhythmia,myxoma size,cardiac chamber size,left ventricular ejection fraction,and the prevalence of complication with coronary artery disease[16%in the ADN group(n=4)vs.20.6%in the non-ADN group(n=7),P=0.66].However,patients with ADN tended to have a lower incidence of major adverse cardiac and cerebrovascular events on long-term follow-up(0%vs.14.7%,P=0.07).Conclusion:CAG-detected ADN in patients with cardiac myxoma is associated with a borderline lower rate of major adverse cardiac and cerebrovascular events.
基金Supported by Fundamental Research Project of Sichuan Provincial Department of Finance in 2012
文摘Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of the new countryside construction data,we give an overview of the database design based on ArcSDE and SQL Server,and elaborate the association between data classification organization,database conceptual design,logical design,spatial data,and thematic attribute data.Finally,taking the provincial new countryside demonstration zone in Yanjiang District of Sichuan Province for example,we build the new countryside construction database.
基金supported by the National Natural Science Foundation of China(22101208,22125803,22020102006)the Fundamental Research Funds for the Central Universitiesthe Program for Professors of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning。
文摘Excitation wavelength dependent(Ex-De) luminescent materials have attracted intense attention due to their great potential in multicolor bioimaging,dynamic anti-counterfeiting,and light emitting devices.However,it remains a formidable challenge to construct an Ex-De luminescent biomaterial with green starting materials,excellent biocompatibility,good water solubility,and multiple color emission for dynamic cell imaging.In this work,nanocomposites based on the facile self-assembly strategy of bovine serum albumin(BSA) and Au(Ⅰ)-complex are rationally designed and synthesized to simultaneously present Ex-De fluorescence(429–516 nm) and decent phosphorescence(~615 nm) in a dilute aqueous solution.Combinatory analyses of spectroscopic and microscopic results reveal that the luminescent mechanism of Au(Ⅰ)-BSA nanocomposites is cluster-induced Ex-De fluorescence and metal-to-ligand charge transition(MLCT) based phosphorescence.Importantly,based on the excellent biocompatibility,water-solubility and color-tunable emission over the entire visible region(360–800 nm),the Au(Ⅰ)-BSA nanocomposites are successfully used for cell imaging with multiple and switchable colors on demand.What is more,the solid tablets of Au(Ⅰ)-BSA nanoparticles showed pressure-responsive luminescence and decent room temperature phosphorescence.This work provides an assembling-induced emission strategy for the design of water-soluble,non-cytotoxic,and color-tunable luminescent biomaterials based on the composite of protein and Au nanoparticles.
基金supported by the National Natural Science Foundation of China (21628401)the National Program for Thousand Young Talents of China
文摘In nanoscience, molecular switches have played a significant role to deliver different control abilities to practical functions,whereas high-contrast luminescence switchable manipulation at nanoscale is still limited. Since the tuning for emission behavior with high contrast ratio strongly connects to numerous visualized sensing and optoelectronic applications, we here report that autonomous p H control can be enrolled to address a high-contrast molecular emission change at the nanoaggregated level, for gaining a flicker luminescence performance in aqueous media. Employing a BODIPY contained dynamic covalent dye, we find its luminescent signal and nanoaggregate size can be spontaneously adjusted in water. On this basis, high-contrast luminescence switching of the material can be achieved upon the alternate introduction of base and acid into the aggregation state. Such a behavior can be attributed to a p H triggered photo-induced electron transfer regulation process. The dye aggregates can be well endocytosed for bioimaging and its luminescent variation can be autonomously displayed as a flicker effect. These results provide new visions for the design and development of smart materials with a dynamic luminescence behavior.
基金supported by Taiyuan University of Technology and the National Natural Science Foundation of China(21975046)。
文摘Organic thermally activated delayed fluorescence(TADF)emitters have attracted increasing concerns,owing to their atypical photophysical features that can pave the way to the innovative engineering applications.As cutting-edge type of luminescent molecules,however,most of them only exert a single-wavelength emission from the lowest excited state,according to Kasha’s rule.To develop their potential applications in multicolor luminescence and multi-functional luminescent probes for biological imaging,researchers have begun to turn their attention to design organic TADF molecules with dual-emission characteristics,by employing an additional fluorescence,phosphorescence,or TADF signal within a single-component system.We herein summarized the design principles as well as the luminescence mechanism of organic donor-acceptor TADF compounds with dual-emission characteristics,the superiority of which can cover unique material applications in modern luminescencerelated fields.