Objective: To delineate and clarify neuromuscular disorders in patients with p robable severe acute respiratory syndrome (SARS). Design: Case series with follo w up ranging from 3 weeks to 2 months. Setting: National ...Objective: To delineate and clarify neuromuscular disorders in patients with p robable severe acute respiratory syndrome (SARS). Design: Case series with follo w up ranging from 3 weeks to 2 months. Setting: National Taiwan University Hosp ital, Taipei. Patients: We investigated 4 patients with SARS who had concomitant neuromuscular problems. A diagnosis of SARS was based on the demonstration of s erum coronavirus antibodies. Clinical presentations, laboratory results, electro physiologic findings, and follow up conditions were determined. Results: Patien ts developed neuromuscular problems approximately 3 weeks after the onset of SAR S. Two women experienced motor predominant peripheral nerve disorders. A man de veloped myopathy and a third woman experienced neuropathy and myopathy. Cerebros pinal fluid obtained from 2 patients with neuropathy disclosed normal protein co ntent and the absence of pleocytosis and SARS coronavirus antibodies. Both patie nts with myopathy had elevated serum creatine kinase levels. A rapid clinical an d electrophysiologic improvement was evident during follow up examinations, wit h a good prognosis. Conclusions: The neuromuscular problems in patients with SAR S are considered to be critical illness polyneuropathy or myopathy, possibly co existent. Further pathological and microbiological studies are necessary to dete rmine the relationship between SARS coronavirus and neuromuscular problems.展开更多
Pd77Cu6Si17(PCS) thin film metallic glasses(TFMGs) with high glass forming ability and hardness were selected as a hard coating for improving the surface hardness of AZ31 magnesium alloy. Both microindentation and nan...Pd77Cu6Si17(PCS) thin film metallic glasses(TFMGs) with high glass forming ability and hardness were selected as a hard coating for improving the surface hardness of AZ31 magnesium alloy. Both microindentation and nanoindentation tests were conducted on specimens with various PCS film thicknesses from 30 to 2000 nm. The apparent hardness and the relative indentation depth(β) were integrated using a quantitative model. The interaction parameters involved and relative hardness values were extracted from iterative calculations. According to the results, surface hardness can be enhanced greatly by PCS TFMGs in the shallow region, followed by gradual decrease with increasing β ratio. In addition, specimens with thinner coatings(e.g., 200nm) showed greater substrate-film interaction and those with thick coatings(e.g., 2000nm) became prone to film cracking. The optimum TFMG coating thickness in this study was estimated to be around 200 nm.展开更多
文摘Objective: To delineate and clarify neuromuscular disorders in patients with p robable severe acute respiratory syndrome (SARS). Design: Case series with follo w up ranging from 3 weeks to 2 months. Setting: National Taiwan University Hosp ital, Taipei. Patients: We investigated 4 patients with SARS who had concomitant neuromuscular problems. A diagnosis of SARS was based on the demonstration of s erum coronavirus antibodies. Clinical presentations, laboratory results, electro physiologic findings, and follow up conditions were determined. Results: Patien ts developed neuromuscular problems approximately 3 weeks after the onset of SAR S. Two women experienced motor predominant peripheral nerve disorders. A man de veloped myopathy and a third woman experienced neuropathy and myopathy. Cerebros pinal fluid obtained from 2 patients with neuropathy disclosed normal protein co ntent and the absence of pleocytosis and SARS coronavirus antibodies. Both patie nts with myopathy had elevated serum creatine kinase levels. A rapid clinical an d electrophysiologic improvement was evident during follow up examinations, wit h a good prognosis. Conclusions: The neuromuscular problems in patients with SAR S are considered to be critical illness polyneuropathy or myopathy, possibly co existent. Further pathological and microbiological studies are necessary to dete rmine the relationship between SARS coronavirus and neuromuscular problems.
基金Project(No.NSC 98-2221-E-110-035-MY3) supported by the National Science Council of Taiwan
文摘Pd77Cu6Si17(PCS) thin film metallic glasses(TFMGs) with high glass forming ability and hardness were selected as a hard coating for improving the surface hardness of AZ31 magnesium alloy. Both microindentation and nanoindentation tests were conducted on specimens with various PCS film thicknesses from 30 to 2000 nm. The apparent hardness and the relative indentation depth(β) were integrated using a quantitative model. The interaction parameters involved and relative hardness values were extracted from iterative calculations. According to the results, surface hardness can be enhanced greatly by PCS TFMGs in the shallow region, followed by gradual decrease with increasing β ratio. In addition, specimens with thinner coatings(e.g., 200nm) showed greater substrate-film interaction and those with thick coatings(e.g., 2000nm) became prone to film cracking. The optimum TFMG coating thickness in this study was estimated to be around 200 nm.
