The situation of tuberculosis （TB） and Mycobacterium tuberculosis （ M. tuberculosis） drug resistance is still very serious in China. Improper treatment for TB may lead to a prolonged course of antimicrobial therap...The situation of tuberculosis （TB） and Mycobacterium tuberculosis （ M. tuberculosis） drug resistance is still very serious in China. Improper treatment for TB may lead to a prolonged course of antimicrobial therapy and spreading of drug resistant strains. Thus, rapid detection of drug resistant strains will allow prompt initiation and adjustment of effective chemotherapeutic treatment of TB. Ethambutol （EMB） is a first line anti-TB drug. embB Met306 is located in a cytoplasmic loop that forms an EMB resistance determining region,展开更多
基金This research was supported by the Army Research Foundation forthe Outstanding Person with Ability (No.01J020).
文摘The situation of tuberculosis （TB） and Mycobacterium tuberculosis （ M. tuberculosis） drug resistance is still very serious in China. Improper treatment for TB may lead to a prolonged course of antimicrobial therapy and spreading of drug resistant strains. Thus, rapid detection of drug resistant strains will allow prompt initiation and adjustment of effective chemotherapeutic treatment of TB. Ethambutol （EMB） is a first line anti-TB drug. embB Met306 is located in a cytoplasmic loop that forms an EMB resistance determining region,
