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H3和IDH野生型弥漫性儿童型高级别胶质瘤6例临床病理分析
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作者 王瑞芬 管雯斌 +3 位作者 严敏骅 琚璐 韩蕙如 王立峰 《临床与实验病理学杂志》 CAS 北大核心 2024年第5期484-489,共6页
目的探讨中枢神经系统H3和IDH野生型弥漫性儿童型高级别胶质瘤的临床病理学及分子特征。方法收集上海交通大学医学院附属新华医院病理科诊断的6例H3和IDH野生型弥漫性儿童型高级别胶质瘤的临床病理资料,采用免疫组化(全自动免疫组化染色... 目的探讨中枢神经系统H3和IDH野生型弥漫性儿童型高级别胶质瘤的临床病理学及分子特征。方法收集上海交通大学医学院附属新华医院病理科诊断的6例H3和IDH野生型弥漫性儿童型高级别胶质瘤的临床病理资料,采用免疫组化(全自动免疫组化染色仪)检测GFAP、Olig2、Syn、NeuN、IDH1、H3K27M等蛋白的表达,FISH法检测EGFR、MYCN基因扩增,Sanger测序检测IDH、H3F3A、TERT基因突变,并复习相关文献。结果本组6例患者年龄范围5~11岁,中位年龄7.5岁。其中男性2例,女性4例,男女比1∶2。临床症状表现为肢体乏力、偏瘫、呕吐、抽搐、视物模糊等。肿瘤发生部位:5例位于幕上,1例位于幕下脑干和小脑。组织学形态:3例表现为高级别胶质瘤形态学特征,其中2例伴有瘤巨细胞;2例表现为胚胎性肿瘤样特征,1例同时具有高级别胶质瘤及胚胎性肿瘤样形态学特点。5例伴有微血管增生和(或)坏死;1例间质黏液变/微囊形成。免疫表型:肿瘤细胞GFAP(6/6)和Olig2(6/6)部分或局灶阳性,Syn(3/6)和NeuN(1/6)局灶或散在阳性,IDH1、H3K27M、H3G34V和H3G34R均阴性,ATRX、H3K27me3、INI1、BRG1均弥漫阳性(6/6)。p53阳性5%~95%不等,Ki67增殖指数40%~90%。分子检测示6例均为IDH1/2和H3F3A野生型;2例MYCN扩增;2例EGFR扩增伴多倍体;1例同时伴有EGFR扩增和MYCN扩增;1例PDGFRA扩增。治疗及随访情况,术后放疗和(或)替莫唑胺化疗;3例于术后1~5个月死亡;2例存活,随访截至2024年1月,分别随访4个月和7个月;1例失访。结论H3和IDH野生型弥漫性儿童型高级别胶质瘤是一种高度恶性肿瘤,组织学表现为胶质母细胞瘤样或胚胎性肿瘤样特征,根据分子遗传学特征分为RTK1、RTK2、MYCN三种分子亚型,其中MYCN亚型预后最差。诊断时应注意与其他儿童型或成人型高级别胶质瘤及胚胎性肿瘤鉴别。 展开更多
关键词 弥漫性儿童型高级别胶质瘤 H3野生型 IDH野生型 鉴别诊断
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Spatio-temporal Changes of ≥10℃ Accumulated Temperature in Northeastern China since 1961 被引量:22
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作者 yan minhua LIU Xingtu +2 位作者 ZHANG Wei LI Xiujun LIU Shi 《Chinese Geographical Science》 SCIE CSCD 2011年第1期17-26,共10页
The objective of this study was to provide reliable basis for decision making for national food security and layout and structure adjustment of grain production in the northeastern China. The data of mean daily air te... The objective of this study was to provide reliable basis for decision making for national food security and layout and structure adjustment of grain production in the northeastern China. The data of mean daily air temperature of 1961-2009 from 106 meteorological stations in the northeastern China were chosen in this study. Using statistical methods and isoline method, the spatio-temporal changes of various decadal ≥ 10℃ accumulated temperature and the climatic means of ≥ 10℃ accumulated temperature were studied in this paper. The results showed that 1) The geo-graphical distribution of ≥ 10℃ accumulated temperature in the northeastern China could be influenced directly by the latitude, longitude and altitude. If latitude moved one degree northward, the average decrease amplitude of the climatic means was 101.9℃ in the study area. 2) The means of decadal ≥ 10℃ accumulated temperature rose since the 1980s, and their increase amplitudes became larger in the 1990s and the 2010s obviously. Compared with those of the 1980s, ≥ 10℃ accumulated temperature increased by about 100℃ in the mountainous and plain areas in the 1990s; compared with those of the 1990s, ≥ 10℃ accumulated temperature increased by about 200℃ in the Hulun Buir High Plain and the Songnen Plain, and 100℃ in the Sanjiang Plain and the Liaohe Plain in the 2010s. 3) The means of the decadal ≥ 10℃ accumulated temperature for 106 meteorological stations in the northeastern China increased with the rate of 145.57℃/10yr in 1961-2009. 4) The climatic means of ≥ 10℃ accumulated temperature increased from 1961-1990 to 1971-2000 and 1981-2009. Compared with the climatic mean of 1971-2000, that of 1981-2009 had increased by above 50℃ in most of the study area, even up to 156℃. Compared with the climatic mean of 1961-1990, that of 1981-2009 increased by above 100℃ in most parts of the study area, even up to 200℃. 5) The maximum northward shift, eastward and westward extension amplitudes of 3100℃, 3300℃ and 3500℃ isolines were larger among all isoli-nes for the climatic means of the three phases. Compared with the positions of the isolines of 1961-1990, those ampli-tudes of 3100℃ isoline of 1981-2009 were 145 km, 109 km and 64 km, respectively; those of 3300℃ isoline were 154 km, 54 km and 64 km, respectively; and the maximum northward shift of 3500℃ isoline was about 100 km. 展开更多
关键词 中国东北地区 时空变化 积温 等值线图 国家粮食安全 年代际 气象观测站 平均值
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Quantitative Assessment of Impacts of Climate and Economic-technical Factors on Grain Yield in Jilin Province from 1980 to 2008
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作者 YAO Zuofang yanG Fei +2 位作者 LIU Xingtu yan minhua MENG Jun 《Chinese Geographical Science》 SCIE CSCD 2011年第5期543-553,共11页
Climate change is one of the most important challenges threatening agricultural grain yield and food security. Determining the factors influencing grain yield in Jilin Province and the weights of their contribution ar... Climate change is one of the most important challenges threatening agricultural grain yield and food security. Determining the factors influencing grain yield in Jilin Province and the weights of their contribution are a very important task, because Jilin Province is an important agriculture base in China. In this study, the accumulation factor sequence evaluating data method was used to analyze the climate and economic-technical factor contribution weights to grain yield and grain yield changes in each city of Jilin Province. Climate yield was also estimated to study the climate effect on the grain yield, and it was calculated in two ways:an improved algorithm and a traditional quadratic method. The results show that the climate and economic-technical factors have different contribution weights to grain yield in different cities in Jilin Province. The contribution weight of the climate factor to grain yield was 0.212-0.349, while that the economic-technical factor was 0.651-0.788. Furthermore, the changes of the climate factor contributing to grain yield changes accounted for 0.296-0.546, and the changes of the economic-technical factor accounted for 0.454-0.704. The weights of climate and economic-technical factor contributing to grain yield are very different between the eastern and western cities in Jilin Province, but their weights contributing to the grain yield change are similar in these cities. In general, the amount of fertilizer used per hectare (FUPH) is the main factor affecting grain yields and yield changes from 1980 to 2008. It is noted that when the FUPH growth rate stabilized after 1995, the effects of the climate factor on the grain yield become more obvious than before. The improved algorithm is effective for estimating climate yield in Jilin Province, and the climate yields were mostly between-500 kg/ha and 500 kg/ha, and showed a slightly rising trend in most cities. 展开更多
关键词 粮食产量 气候变化 技术因素 定量评估 吉林省 经济 农业基地 产量估计
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Advance in Application of Regional Climate Models in China
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作者 ZHANG Wei yan minhua +1 位作者 CHEN Panqin XU Helan 《Chinese Geographical Science》 SCIE CSCD 2008年第1期93-100,共8页
Regional climate models have become the powerful tools for simulating regional climate and its change process and have been widely used in China. Using regional climate models, some research results have been obtained... Regional climate models have become the powerful tools for simulating regional climate and its change process and have been widely used in China. Using regional climate models, some research results have been obtained on the following aspects: 1) the numerical simulation of East Asian monsoon climate, including exceptional monsoon precipitation, summer precipitation distribution, East Asian circulation, multi-year climate average condition, summer rain belt and so on; 2) the simulation of arid climate of the western China, including thermal effect of the Qing- hai-Tibet Plateau, the plateau precipitation in the Qilian Mountains; and the impacts of greenhouse effects (CO2 dou- bling) upon climate in the western China; and 3) the simulation of the climate effect of underlying surface changes, in- cluding the effect of soil on climate formation, the influence of terrain on precipitation, the effect of regional soil deg- radation on regional climate, the effect of various underlying surfaces on regional climate, the effect of land-sea con- trast on the climate formulation, the influence of snow cover over the plateau regions on the regional climate, the effect of vegetation changes on the regional climate, etc. In the process of application of regional climate models, the prefer- ences of the models are improved so that better simulation results are gotten. At last, some suggestions are made about the application of regional climate models in regional climate research in the future. 展开更多
关键词 气候模型 中国 测试方法 数字模拟
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科技期刊联合编辑部编辑岗位绩效评价管理实践 被引量:3
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作者 商丽娜 张慧敏 +4 位作者 张春丽 闫敏华 宋晓林 罗玲 王景 《中国科技期刊研究》 CSSCI 北大核心 2019年第5期512-517,共6页
【目的】针对科技期刊联合编辑部管理特点,构建实际工作中科学、合理、可行的编辑绩效考核方法,为期刊管理部门提供参考。【方法】整合分析对多个科技期刊联合编辑部的调研结果及现有文献,结合中国科学院东北地理与农业生态研究所期刊... 【目的】针对科技期刊联合编辑部管理特点,构建实际工作中科学、合理、可行的编辑绩效考核方法,为期刊管理部门提供参考。【方法】整合分析对多个科技期刊联合编辑部的调研结果及现有文献,结合中国科学院东北地理与农业生态研究所期刊编辑部管理工作实践,总结联合编辑部编辑绩效评价基本原则,遴选编辑岗位绩效考核指标,构建定性与定量相结合的编辑岗位绩效考核体系。【结果】联合编辑部编辑岗位绩效评价应遵循公平性、客观性、可操作性、导向性和公开性原则;绩效考核体系应对接联合编辑部主办单位的绩效考核体系。工作作风、个人能力与素质可采用定性方式进行评价;编校工作量、编务工作量、编辑个人发展和期刊发展等指标可采用定量方式进行评价。中国科学院东北地理与农业生态研究所的实践应用取得较为理想的评价结果,表明本研究构建的绩效评价方案具有可行性。【结论】联合编辑部编辑岗位绩效评价比单刊编辑部复杂,指标体系的构建应在明确编辑岗位分工的基础上,结合联合编辑部的工作特点,谨慎遴选指标;在具体的实践工作中,动态调整、完善考核指标体系,以达到奖勤罚懒、奖优罚劣、提高编辑绩效水平的目的。 展开更多
关键词 联合编辑部 学术编辑 绩效评价 科技期刊
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S波段高功率微波对短波通信电台的损伤效应试验研究 被引量:2
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作者 闫民华 刘国强 +2 位作者 杨杰 李跃波 潘征 《防护工程》 2019年第2期19-23,共5页
高功率微波能对短波通信电台等电子信息设备产生不同程度的损伤。利用高功率微波模拟试验系统,研究了S波段高功率微波对短波通信电台的损伤效应,通过改变微波源和短波通信电台设置得到了损伤规律,分析了损伤机理,确定了受试样本的损伤阈... 高功率微波能对短波通信电台等电子信息设备产生不同程度的损伤。利用高功率微波模拟试验系统,研究了S波段高功率微波对短波通信电台的损伤效应,通过改变微波源和短波通信电台设置得到了损伤规律,分析了损伤机理,确定了受试样本的损伤阈值,并通过三参数威布尔函数法拓展得到了短波通信电台的损伤阈值范围。 展开更多
关键词 S波段 高功率微波 短波通信电台 损伤效应
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