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恶性黑色素瘤的免疫治疗进展 被引量:6
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作者 严森林(综述) 赵颖海(审校) 《海南医学》 CAS 2021年第3期354-358,共5页
恶性黑色素瘤(malignant melanoma)是一种多发生于皮肤的高度恶性肿瘤,发病率正逐步升高,为皮肤的首位致死性疾病。常规的治疗方法包括手术、化疗、放疗、热疗及免疫治疗等。目前用于恶性黑色素瘤免疫和靶向治疗的药物包括细胞因子、激... 恶性黑色素瘤(malignant melanoma)是一种多发生于皮肤的高度恶性肿瘤,发病率正逐步升高,为皮肤的首位致死性疾病。常规的治疗方法包括手术、化疗、放疗、热疗及免疫治疗等。目前用于恶性黑色素瘤免疫和靶向治疗的药物包括细胞因子、激酶抑制剂、免疫检查点抑制剂等,本文对上述药物的应用、疗效及安全性等进行综述。 展开更多
关键词 黑色素瘤 细胞因子 激酶抑制剂 免疫检查点抑制剂 免疫相关不良事件
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Controlling Chaos in a Semiconductor Laser via Weak Optical Positive Feedback and Modulating Amplitude 被引量:2
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作者 yan sen-lin 《Communications in Theoretical Physics》 SCIE CAS CSCD 2007年第3期491-494,共4页
Numerical analysis of weak optical positive feedback (OPF) controlling chaos is studied in a semiconductor laser. The physical model of controlling chaos produced via modulating the current of semiconductor laser is... Numerical analysis of weak optical positive feedback (OPF) controlling chaos is studied in a semiconductor laser. The physical model of controlling chaos produced via modulating the current of semiconductor laser is presented under the condition of OPF. We find the physical mechanism that the nonlinear gain coefficient and linewidth enhance- ment factor of the laser are affected by OPF so that the dynamical behaviour of the system can be efficiently controlled. Chaos is controlled into a single-periodic state, a dual-periodic state, a tri-periodic state, a quadr-periodic state, a pentaperiodic state, and the laser emitting powers are increased by OPF in simulations. Lastly, another chaos-control method with modulating the amplitude of the feedback light is presented and numerically simulated to control chaotic laser into multi-periodic states. 展开更多
关键词 CHAOS control positive feedback PERIOD
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Theory of Dynamics In-Phase Locking and Quasi-Period Synchronization in Two Mutually Coupled Multi-Quantum-Well Lasers 被引量:1
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作者 yan sen-lin 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第3期481-488,共8页
Abstract We study dynamics in two mutually coupling multi-quantum-well lasers. We carry out theoretical and numerical analysis of synchronization, anti-synchronization, in-phase locking in the two identical lasers but... Abstract We study dynamics in two mutually coupling multi-quantum-well lasers. We carry out theoretical and numerical analysis of synchronization, anti-synchronization, in-phase locking in the two identical lasers but detuning, in detain. It is proved that the coupling level determines stability of the lasers by analyzing the eigenvalue equation. Critical case of locking is discussed via the phase difference equation. Quasi-period and stable states in the two lasers are investigated via varying the current, detuning and coupling level. 展开更多
关键词 in-phase locking SYNCHRONIZATION multi-quantum-well laser COUPLING
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Theoretical model of optical fiber secure communication system with chaotic multiple-quantum-well lasers
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作者 yan sen-lin 《Optoelectronics Letters》 EI 2007年第5期363-367,共5页
Chaotic synchronization of injected multiple-quantum-well lasers of optical fiber system and a theoretical model of optical fiber chaotic secure communication system are presented by coupling a chaotic multiple-quantu... Chaotic synchronization of injected multiple-quantum-well lasers of optical fiber system and a theoretical model of optical fiber chaotic secure communication system are presented by coupling a chaotic multiple-quantum-weU laser synchronization system and a fiber channel. A new chaotic encoding method of chaos phase shift keying On/Off is proposed for optical fiber secure communications. Chaotic synchronization is achieved numerically in long-haul fiber system at wavelength 1.55 μm. The effect of the nonlinear-phase of fiber is analyzed on chaotic signal and synchronization. A sinusoidal signal of 0.2 GHz frequency is simulated numerically with chaos masking in long-haul fiber analog communication at wavelength 1.55 μm while a digital signal of 0.5 Gbit/s bit rate is simulated numerically with c^1 haos masking and a rate of 0.05 Gbit/s are also simulated numerically with chaos shift keying and chaos phase shift keying On/Off in long-haul fiber digital communications at wavelength 1.55μm 展开更多
关键词 光纤通信系统 通信安全 理论模式 激光
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