恶性黑色素瘤的免疫治疗进展

恶性黑色素瘤(malignant melanoma)是一种多发生于皮肤的高度恶性肿瘤,发病率正逐步升高,为皮肤的首位致死性疾病。常规的治疗方法包括手术、化疗、放疗、热疗及免疫治疗等。目前用于恶性黑色素瘤免疫和靶向治疗的药物包括细胞因子、激酶抑制剂、免疫检查点抑制剂等,本文对上述药物的应用、疗效及安全性等进行综述。

Controlling Chaos in a Semiconductor Laser via Weak Optical Positive Feedback and Modulating Amplitude

控制混乱的弱光积极反馈(OPF ) 的数字分析在半导体激光被学习。控制经由 modulating 生产的混乱的物理模型半导体激光的水流在 OPF 的条件下面被介绍。我们发现非线性的获得系数和激光的线宽改进因素被 OPF 影响的物理机制以便系统的动态行为能高效地被控制。控制进射出力量的一个单人赛周期的状态，一个双周期的状态，一个 tri 周期的状态， aquadr 周期的状态，一个 penta 周期的状态，和激光的 Chaosis 被 OPF 在模拟增加。最后，反馈光的振幅被介绍并且数字地模仿了控制混乱激光进多周期的状态的有 modulating 的另一个混乱控制方法。

Theory of Dynamics In-Phase Locking and Quasi-Period Synchronization in Two Mutually Coupled Multi-Quantum-Well Lasers

我们互相在二学习动力学联合 multi-quantum-well 激光。我们执行同步的理论、数字的分析，反同步，在二相同激光的同相的锁住但是 detuning，在里面耽搁。联合水平由分析特征值方程决定激光的稳定性，这被证明。锁住的批评大小写经由阶段差别方程被讨论。在二激光的伪时期和稳定的状态经由改变水流， detuning 和联合水平被调查。

Theoretical model of optical fiber secure communication system with chaotic multiple-quantum-well lasers

Chaotic synchronization of injected multiple-quantum-well lasers of optical fiber system and a theoretical model of optical fiber chaotic secure communication system are presented by coupling a chaotic multiple-quantum-well laser synchroniza- tion system and a fiber channel. A new chaotic encoding method of chaos phase shift keying On/Off is proposed for optical fiber secure communications. Chaotic synchronization is achieved numerically in long-haul fiber system at wavelength 1.55 μm. The effect of the nonlinear-phase of fiber is analyzed on chaotic signal and synchronization. A sinusoidal signal of 0.2 GHz frequency is simulated numerically with chaos masking in long-haul fiber analog communication at wavelength 1.55 μm while a digital signal of 0.5 Gbit/s bit rate is simulated numerically with c1haos masking and a rate of 0.05 Gbit/s are also simulated numerically with chaos shift keying and chaos phase shift keying On/Off in long-haul fiber digital communica- tions at wavelength 1.55