The quantum simulation model and the self-consistent computational algorithm we proposed two years ago are utilized to investigate the physical properties of a magnetic nanowire consisting of 3𝑒ions which are ...The quantum simulation model and the self-consistent computational algorithm we proposed two years ago are utilized to investigate the physical properties of a magnetic nanowire consisting of 3𝑒ions which are coupled antiferromagnetically.In the absence of the external magnetic field,all simulations are started from a spin configuration with all moments in the nanosample randomly oriented and performed from a temperature above the magnetic transition temperature𝑈M down to very low temperature as carried out by previous researchers using the Monte Carlo method,and such obtained results are all physically reasonable,verifying the correctness of the simulation model and computing algorithm.In addition,our calculated results suggest that increasing the surface anisotropy enables an increase in the magnetic transition temperature,although less effectively than by enhancing the Heisenberg exchange strength directly.展开更多
目的观察宫颈癌患者癌组织Dickkopf相关蛋白3(Dickkopf-3,DKK3)、分泌型卷曲相关蛋白5(secreted frizzled-related protein 5,SFRP5)基因甲基化情况,探讨其与临床病理特征及预后的关系。方法 123例宫颈癌患者,均行手术治疗,取手术切除...目的观察宫颈癌患者癌组织Dickkopf相关蛋白3(Dickkopf-3,DKK3)、分泌型卷曲相关蛋白5(secreted frizzled-related protein 5,SFRP5)基因甲基化情况,探讨其与临床病理特征及预后的关系。方法 123例宫颈癌患者,均行手术治疗,取手术切除的癌组织和癌旁正常宫颈组织,采用甲基化特异性PCR检测2种组织DKK3、SFRP5基因甲基化情况;比较不同分化程度、FIGO分期等临床病理特征者癌组织DKK3、SFRP5基因甲基化率;术后随访3年,采用Kaplan-Meier法分析DKK3、SFRP5基因甲基化者与无甲基化者3年无瘤生存率和总生存率;采用多因素Cox回归分析宫颈癌患者预后不良的危险因素。结果宫颈癌患者癌组织DKK3、SFRP5基因甲基化率(61.79%、70.73%)均高于癌旁组织(26.02%、30.89%)(χ^(2)=31.955,P<0.001;χ^(2)=39.051,P<0.001)。低中度分化(72.50%、77.50%)、FIGO分期Ⅲ期(71.43%、77.92%)、有盆腔淋巴结转移(82.89%、85.71%)的宫颈癌患者癌组织DKK3、SFRP5基因甲基化率分别高于高度分化(41.86%、58.14%)、FIGO分期Ⅰ~Ⅱ期(45.65%、58.70%)、无盆腔淋巴结转移者(53.41%、64.77%)(P<0.05)。DKK3、SFRP5基因甲基化的宫颈癌患者3年无瘤生存率(69.74%、72.41%)、总生存率(82.89%、83.91%)均低于DKK3、SFRP5基因无甲基化者(89.36%、88.89%,95.74%、97.22%)(P<0.05)。有盆腔淋巴结转移(HR=1.606,95%CI:1.140~2.264,P=0.003)、DKK3基因甲基化(HR=1.280,95%CI:1.063~1.542,P=0.004)、SFRP5基因甲基化(HR=1.365,95%CI:1.079~1.727,P=0.005)是宫颈癌患者预后不良的危险因素。结论宫颈癌患者癌组织DKK3、SFRP5基因甲基化率升高,低中度分化、FIGO分期Ⅲ期、有盆腔淋巴结转移者癌组织DKK3、SFRP5基因易发生甲基化,预后较差。展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 11274177,1105075,1104146,10804053 and 11047143.
文摘The quantum simulation model and the self-consistent computational algorithm we proposed two years ago are utilized to investigate the physical properties of a magnetic nanowire consisting of 3𝑒ions which are coupled antiferromagnetically.In the absence of the external magnetic field,all simulations are started from a spin configuration with all moments in the nanosample randomly oriented and performed from a temperature above the magnetic transition temperature𝑈M down to very low temperature as carried out by previous researchers using the Monte Carlo method,and such obtained results are all physically reasonable,verifying the correctness of the simulation model and computing algorithm.In addition,our calculated results suggest that increasing the surface anisotropy enables an increase in the magnetic transition temperature,although less effectively than by enhancing the Heisenberg exchange strength directly.
文摘目的观察宫颈癌患者癌组织Dickkopf相关蛋白3(Dickkopf-3,DKK3)、分泌型卷曲相关蛋白5(secreted frizzled-related protein 5,SFRP5)基因甲基化情况,探讨其与临床病理特征及预后的关系。方法 123例宫颈癌患者,均行手术治疗,取手术切除的癌组织和癌旁正常宫颈组织,采用甲基化特异性PCR检测2种组织DKK3、SFRP5基因甲基化情况;比较不同分化程度、FIGO分期等临床病理特征者癌组织DKK3、SFRP5基因甲基化率;术后随访3年,采用Kaplan-Meier法分析DKK3、SFRP5基因甲基化者与无甲基化者3年无瘤生存率和总生存率;采用多因素Cox回归分析宫颈癌患者预后不良的危险因素。结果宫颈癌患者癌组织DKK3、SFRP5基因甲基化率(61.79%、70.73%)均高于癌旁组织(26.02%、30.89%)(χ^(2)=31.955,P<0.001;χ^(2)=39.051,P<0.001)。低中度分化(72.50%、77.50%)、FIGO分期Ⅲ期(71.43%、77.92%)、有盆腔淋巴结转移(82.89%、85.71%)的宫颈癌患者癌组织DKK3、SFRP5基因甲基化率分别高于高度分化(41.86%、58.14%)、FIGO分期Ⅰ~Ⅱ期(45.65%、58.70%)、无盆腔淋巴结转移者(53.41%、64.77%)(P<0.05)。DKK3、SFRP5基因甲基化的宫颈癌患者3年无瘤生存率(69.74%、72.41%)、总生存率(82.89%、83.91%)均低于DKK3、SFRP5基因无甲基化者(89.36%、88.89%,95.74%、97.22%)(P<0.05)。有盆腔淋巴结转移(HR=1.606,95%CI:1.140~2.264,P=0.003)、DKK3基因甲基化(HR=1.280,95%CI:1.063~1.542,P=0.004)、SFRP5基因甲基化(HR=1.365,95%CI:1.079~1.727,P=0.005)是宫颈癌患者预后不良的危险因素。结论宫颈癌患者癌组织DKK3、SFRP5基因甲基化率升高,低中度分化、FIGO分期Ⅲ期、有盆腔淋巴结转移者癌组织DKK3、SFRP5基因易发生甲基化,预后较差。
