目的构建食管癌患者术后静脉血栓栓塞症风险预测模型。方法采用便利抽样选取2020年1月-2022年4月在某三级甲等医院行食管静脉血栓栓塞症癌根治术的220例患者作为建模组,分为静脉血栓栓塞症组60例和非静脉血栓栓塞症组160例。采用Logisti...目的构建食管癌患者术后静脉血栓栓塞症风险预测模型。方法采用便利抽样选取2020年1月-2022年4月在某三级甲等医院行食管静脉血栓栓塞症癌根治术的220例患者作为建模组,分为静脉血栓栓塞症组60例和非静脉血栓栓塞症组160例。采用Logistic回归分析建立食管癌患者术后静脉血栓栓塞症风险预测模型并对模型验证。结果年龄≥60岁、基础疾病、新辅助化疗、手术时长、术后使用凝血酶原复合物(prothrombin complex concentrates,PCC)、术后12 h D-D是食管癌患者术后静脉血栓栓塞症危险因素。HL检验P=0.250,受试者工作曲线特征曲线下面积(area under curve,AUC)为0.766,最佳临界值为0.445,灵敏度为0.783,特异度为0.662。验证组AUC为0.738,灵敏度为0.682,特异度为0.769,正确率为80.0%。结论该预测模型的预测效果良好,可为临床评估食管癌患者术后静脉血栓栓塞症发生风险提供参考。展开更多
O3 is not only greenhouse gas but also a primary gaseous contaminant in the atmosphere.It has long-lasting effects on crop growth,yield and quality,and brings a series of ecological and environmental problems.A free-a...O3 is not only greenhouse gas but also a primary gaseous contaminant in the atmosphere.It has long-lasting effects on crop growth,yield and quality,and brings a series of ecological and environmental problems.A free-air controlled enrichment（FACE） system was applied to study the effect of elevated ozone concentration on activities of key enzymes of starch synthesis of Yangmai 16 in 2009-2010.The main-plot treatment had two levels of O 3 ：ambient level（A-O 3） and 50% higher than ambient level（E-O 3）.The main results were that accumulation rate of amylose,amylopectin and starch were represented in a single peak curve,and their content and accumulation amount rose gradually.The O 3 elevation decreased the accumulation rate of amylose,amylopectin and starch amylase,reduced the accumulation amount of amylopectin and starch,and decreased the content of amylopectin and starch,but increased the content of amylose.With the increase of O 3 concentration,the enzyme activity of grain granule-bound starch synthase（GBSS）,soluble starch synthase（SSS） and starch branching enzyme（SBE） decreased after anthesis.The activities of GBSS and SSS had highly significant correlations with amylose,amylopectin and starch accumulation rate,and the activity of SBE had significant correlations with these items.So the O 3 elevation decreased the activity of key enzymes of starch synthesis,which led to the variation of starch synthesis.展开更多
Natural rubber(NR)is an irreplaceable biopolymer of economic and strategic importance owing to its unique physical and chemical properties.The Parárubber tree(Hevea brasiliensis(Willd.ex A.Juss.)Müll.Arg.)is...Natural rubber(NR)is an irreplaceable biopolymer of economic and strategic importance owing to its unique physical and chemical properties.The Parárubber tree(Hevea brasiliensis(Willd.ex A.Juss.)Müll.Arg.)is currently the exclusive commercial source of NR,and it is primarily grown in plantations restricted to the tropical and subtropical areas of Southeast Asia.However,current Parárubber production barely meets the sharply increasing global industrial demand for rubber.Petroleum-based synthetic rubber(SR)has been used to supplement the shortage of NR but its industrial performance is not comparable to that of NR.Thus,there is an urgent need to develop new productive rubber crops with broader environmental adaptability.This review summarizes the current research progress on alternative rubberproducing plants,including horticultural plants(Taraxacum kok-saghyz Rodin and Lactuca L.species),woody plants(Parthenium argentatum A.Gray and Eucommia ulmoides Oliv.),and other plant species with potential for NR production.With an emphasis on the molecular basis of NR biosynthesis revealed by a multi-omics approach,we highlight new integrative strategies and biotechnologies for exploring the mechanism of NR biosynthesis with a broader scope,which may accelerate the breeding and improvement of new rubber crops.展开更多
目的分析双时相三维稳态进动快速成像序列(3DSSFP)对先天性心脏(CHD)大血管畸形的诊断价值。方法对我院近两年(2015年12月-2017年12月)收治的经超声诊断为CHD的46例患者先心病患者在术前或术后均采用胸部双时相3DSSFP成像及传统对比剂...目的分析双时相三维稳态进动快速成像序列(3DSSFP)对先天性心脏(CHD)大血管畸形的诊断价值。方法对我院近两年(2015年12月-2017年12月)收治的经超声诊断为CHD的46例患者先心病患者在术前或术后均采用胸部双时相3DSSFP成像及传统对比剂增强磁共振血管成像(CE-MRA)技术,比较两种MR检查获得的先心病患者大血管图像质量及测得的大血管直径,分析评估双时相3DSSFP成像技术在先天性心脏(CHD大血管畸形中的诊断效能。结果两种MR检查获得的先心病患者大血管图像质量无显著差异(P>0.05);3DSSFP收缩期、舒张期及CE-MRA测得的主动脉、左肺动脉、右肺动脉直径差异显著(P<0.05),肺总动脉及下腔静脉直径无显著差异(P>0.05),3DSSFP收缩期测得的主动脉、肺总动脉、右肺动脉直径显著大于舒张期(P<0.05),左肺动脉及下腔静脉直径与舒张期无显著差异(P>0.05)。结论 3D SSFP成像技术能清晰显示先天性心脏病患者的大血管形态变化,且能准确测量不同心动时期大血管直径,有助于临床制定合理的治疗方案,提高CHD患者的治疗效果。展开更多
文摘目的构建食管癌患者术后静脉血栓栓塞症风险预测模型。方法采用便利抽样选取2020年1月-2022年4月在某三级甲等医院行食管静脉血栓栓塞症癌根治术的220例患者作为建模组,分为静脉血栓栓塞症组60例和非静脉血栓栓塞症组160例。采用Logistic回归分析建立食管癌患者术后静脉血栓栓塞症风险预测模型并对模型验证。结果年龄≥60岁、基础疾病、新辅助化疗、手术时长、术后使用凝血酶原复合物(prothrombin complex concentrates,PCC)、术后12 h D-D是食管癌患者术后静脉血栓栓塞症危险因素。HL检验P=0.250,受试者工作曲线特征曲线下面积(area under curve,AUC)为0.766,最佳临界值为0.445,灵敏度为0.783,特异度为0.662。验证组AUC为0.738,灵敏度为0.682,特异度为0.769,正确率为80.0%。结论该预测模型的预测效果良好,可为临床评估食管癌患者术后静脉血栓栓塞症发生风险提供参考。
基金supported by the Innovation Program of Chinese Academy of Sciences(KZCX2-EW-414)the International S&T Cooperation Program of China(2009DFA31110)the Qing Lan Project Knowledge,Priority Academic Program Development of Jiangsu Higher Education Institutions,China and the Global Environment Research Fund,Ministry of the Environment,Japan(C-062)
文摘O3 is not only greenhouse gas but also a primary gaseous contaminant in the atmosphere.It has long-lasting effects on crop growth,yield and quality,and brings a series of ecological and environmental problems.A free-air controlled enrichment（FACE） system was applied to study the effect of elevated ozone concentration on activities of key enzymes of starch synthesis of Yangmai 16 in 2009-2010.The main-plot treatment had two levels of O 3 ：ambient level（A-O 3） and 50% higher than ambient level（E-O 3）.The main results were that accumulation rate of amylose,amylopectin and starch were represented in a single peak curve,and their content and accumulation amount rose gradually.The O 3 elevation decreased the accumulation rate of amylose,amylopectin and starch amylase,reduced the accumulation amount of amylopectin and starch,and decreased the content of amylopectin and starch,but increased the content of amylose.With the increase of O 3 concentration,the enzyme activity of grain granule-bound starch synthase（GBSS）,soluble starch synthase（SSS） and starch branching enzyme（SBE） decreased after anthesis.The activities of GBSS and SSS had highly significant correlations with amylose,amylopectin and starch accumulation rate,and the activity of SBE had significant correlations with these items.So the O 3 elevation decreased the activity of key enzymes of starch synthesis,which led to the variation of starch synthesis.
基金This work was supported by the National Key Research and Development Program of China(2019YFD1002701-02)the National Natural Science Foundation of China(32170371)the Strategic Priority Research Program of Chinese Academy of Sciences(XDA24030503).
文摘Natural rubber(NR)is an irreplaceable biopolymer of economic and strategic importance owing to its unique physical and chemical properties.The Parárubber tree(Hevea brasiliensis(Willd.ex A.Juss.)Müll.Arg.)is currently the exclusive commercial source of NR,and it is primarily grown in plantations restricted to the tropical and subtropical areas of Southeast Asia.However,current Parárubber production barely meets the sharply increasing global industrial demand for rubber.Petroleum-based synthetic rubber(SR)has been used to supplement the shortage of NR but its industrial performance is not comparable to that of NR.Thus,there is an urgent need to develop new productive rubber crops with broader environmental adaptability.This review summarizes the current research progress on alternative rubberproducing plants,including horticultural plants(Taraxacum kok-saghyz Rodin and Lactuca L.species),woody plants(Parthenium argentatum A.Gray and Eucommia ulmoides Oliv.),and other plant species with potential for NR production.With an emphasis on the molecular basis of NR biosynthesis revealed by a multi-omics approach,we highlight new integrative strategies and biotechnologies for exploring the mechanism of NR biosynthesis with a broader scope,which may accelerate the breeding and improvement of new rubber crops.
文摘目的分析双时相三维稳态进动快速成像序列(3DSSFP)对先天性心脏(CHD)大血管畸形的诊断价值。方法对我院近两年(2015年12月-2017年12月)收治的经超声诊断为CHD的46例患者先心病患者在术前或术后均采用胸部双时相3DSSFP成像及传统对比剂增强磁共振血管成像(CE-MRA)技术,比较两种MR检查获得的先心病患者大血管图像质量及测得的大血管直径,分析评估双时相3DSSFP成像技术在先天性心脏(CHD大血管畸形中的诊断效能。结果两种MR检查获得的先心病患者大血管图像质量无显著差异(P>0.05);3DSSFP收缩期、舒张期及CE-MRA测得的主动脉、左肺动脉、右肺动脉直径差异显著(P<0.05),肺总动脉及下腔静脉直径无显著差异(P>0.05),3DSSFP收缩期测得的主动脉、肺总动脉、右肺动脉直径显著大于舒张期(P<0.05),左肺动脉及下腔静脉直径与舒张期无显著差异(P>0.05)。结论 3D SSFP成像技术能清晰显示先天性心脏病患者的大血管形态变化,且能准确测量不同心动时期大血管直径,有助于临床制定合理的治疗方案,提高CHD患者的治疗效果。
