目的 基于网络药理学研究金砂行气胶囊治疗慢性浅表性胃炎的药理作用与分子机制。方法 构建慢性浅表性胃炎大鼠模型,评价金砂行气胶囊治疗慢性浅表性胃炎的药理作用。借助TCMSP数据库筛选出复方金砂行气胶囊的主要有效成分及相关作用靶...目的 基于网络药理学研究金砂行气胶囊治疗慢性浅表性胃炎的药理作用与分子机制。方法 构建慢性浅表性胃炎大鼠模型,评价金砂行气胶囊治疗慢性浅表性胃炎的药理作用。借助TCMSP数据库筛选出复方金砂行气胶囊的主要有效成分及相关作用靶点,利用Cytoscape软件构建“成分-疾病-靶点”交互作用网络,借助David数据库对关键靶点进行GO和KEGG通路富集分析。结果 金砂行气胶囊能有效改善大鼠的慢性浅表性胃炎症状。网络药理学分析表明,金砂行气胶囊主要是通过槲皮素、山柰酚、木犀草素、熊果酸、β-谷甾醇、异鼠李素等15个活性化合物,调节癌症通路(pathways in cancer)、肿瘤坏死因子(TNF signal in pathway)、PI3K-Akt信号通路(PI3K-Akt signal in pathway)、MAPK信号通路(MAPK signal in pathway)等相关通路中的TP53、Akt1、IL-6、TNF、CASP3、MAPK1、MAPK3、JUN、IL-10等20个潜在靶点发挥药理作用的。结论 金砂行气胶囊能有效缓解慢性浅表性胃炎模型大鼠的症状,是通过多成分、多靶点、多途径协同发挥作用。展开更多
In this paper, the acoustic scale effects and boundary effects for the similitude model of underwater complex shell-structure are investigated. The similitude conditions and relations between the similitude model and ...In this paper, the acoustic scale effects and boundary effects for the similitude model of underwater complex shell-structure are investigated. The similitude conditions and relations between the similitude model and its prototype were studied in the references. This paper investigates the acoustic scale effects for the similitude model, which are influenced by loss factor, shear and rotatory inertia. At the same time, the boundary effects which are influenced by surface sound reflection are investigated in the experiment of similitude model. The results show that the acoustic scale effects may be controlled with model designing, the boundary effects can be controlled with experimental designing between the similitude model and its prototype.展开更多
文摘目的 基于网络药理学研究金砂行气胶囊治疗慢性浅表性胃炎的药理作用与分子机制。方法 构建慢性浅表性胃炎大鼠模型,评价金砂行气胶囊治疗慢性浅表性胃炎的药理作用。借助TCMSP数据库筛选出复方金砂行气胶囊的主要有效成分及相关作用靶点,利用Cytoscape软件构建“成分-疾病-靶点”交互作用网络,借助David数据库对关键靶点进行GO和KEGG通路富集分析。结果 金砂行气胶囊能有效改善大鼠的慢性浅表性胃炎症状。网络药理学分析表明,金砂行气胶囊主要是通过槲皮素、山柰酚、木犀草素、熊果酸、β-谷甾醇、异鼠李素等15个活性化合物,调节癌症通路(pathways in cancer)、肿瘤坏死因子(TNF signal in pathway)、PI3K-Akt信号通路(PI3K-Akt signal in pathway)、MAPK信号通路(MAPK signal in pathway)等相关通路中的TP53、Akt1、IL-6、TNF、CASP3、MAPK1、MAPK3、JUN、IL-10等20个潜在靶点发挥药理作用的。结论 金砂行气胶囊能有效缓解慢性浅表性胃炎模型大鼠的症状,是通过多成分、多靶点、多途径协同发挥作用。
基金Supported by Specialized Research Fund for the Doctoral Program of Higher Education Under Grant No. 20030317013.
文摘In this paper, the acoustic scale effects and boundary effects for the similitude model of underwater complex shell-structure are investigated. The similitude conditions and relations between the similitude model and its prototype were studied in the references. This paper investigates the acoustic scale effects for the similitude model, which are influenced by loss factor, shear and rotatory inertia. At the same time, the boundary effects which are influenced by surface sound reflection are investigated in the experiment of similitude model. The results show that the acoustic scale effects may be controlled with model designing, the boundary effects can be controlled with experimental designing between the similitude model and its prototype.