铜绿假单胞菌疫苗的研究进展

铜绿假单胞菌是院内感染常见的条件致病菌之一,其感染严重威胁人类公共健康。铜绿假单胞菌复杂的耐药机制使得临床抗生素治疗变得非常困难,需要寻找新的治疗方法。近年来,组分苗[如脂多糖(lipopolysaccharide,LPS)、胞外多糖(extracellular polysaccharide,EPS)、鞭毛等]、亚单位疫苗[如外膜蛋白(outer membrane protein,OMP)]、全菌体灭活疫苗、减毒活疫苗等铜绿假单胞菌疫苗已开展研究。有多个疫苗产品进入临床研究阶段,截至目前为止,尚无批准的铜绿假单胞菌疫苗上市。本文对铜绿假单胞菌疫苗的研究进展作一综述,并对疫苗研发中出现的问题进行讨论。

A widely tunable microwave photonic notch filter with adjustable bandwidth based on multi-wavelength fiber laser

A widely tunable microwave photonic notch filter with adjustable bandwidth based on multi-wavelength fiber laser is proposed and demonstrated. The multi-wavelength fiber laser generates the multi-taps of the microwave photonic filter （MPF）. In order to obtain notch frequency response, a Fourier-domain optical processor （FD-OP） is introduced to con- trol the amplitude and phase of the optical carrier and phase modulation sidebands. By adjusting the polarization con- troller （PC）, different numbers of taps are got, such as 6, 8, 10 and 121 And the wavelength-spacing of the multi-wavelength laser is 0.4 nm. The bandwidth of the notch filter is changed by adjusting the number of taps and the corresponding bandwidths are 4.41 GHz, 3.30 GHz, 2.64 GHz and 2.19 GHz, respectively. With the additional phase shift introduced by FD-OP, the notch position is continuously ttmed in the whole free spectral range （FSR） of 27.94 GHz. The center frequency of the notch filter can be continuously tuned from 13.97 GHz to 41.91 GHz.

人源化单克隆抗体的研究进展

人源化单克隆抗体目前在肿瘤、自身免疫病、抗病毒等多个治疗领域发挥着越来越重要的作用。截止目前,FDA已有50多种人源化抗体药物获批上市,人源化抗体为人类疾病的治疗提供了广阔的思路。抗体人源化技术包括嵌合抗体技术、人源化抗体技术和全人源抗体技术,并随之衍生出单链抗体、双特异性抗体、纳米抗体等多种形式的小分子人源化单克隆抗体。本文对人源化单克隆抗体技术及人源化抗体的发展形势作一综述。