Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are limited.This study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible rel...Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are limited.This study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum women.Methods A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this study.The urinary iodine concentration(UIC),TSH,VA,and VD were measured.Results The median UIC of total and lactating participants were 142.00µg/L and 139.95µg/L,respectively.The median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,respectively.No differences in the UIC were found between lactating and non-lactating mothers.UIC and TSH levels were significantly different among the three provinces.The rural UIC was higher than the urban UIC.Obese mothers had a higher UIC and a higher prevalence of excessive TSH.Higher UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient group.After adjustment,no linear correlation was observed between UIC and VA/VD.No interaction was found between vitamins A/D and UIC on TSH levels.Conclusion The mothers in the present study had no iodine deficiency.Region,area type,BMI,and VD may be related to the iodine status or TSH levels.展开更多
Pb is a well-known toxic metal that has attracted considerable attention because of its ubiquitous distribution in the environment owing to the recent industrialization and rapid urbanization in China. In general, Pb ...Pb is a well-known toxic metal that has attracted considerable attention because of its ubiquitous distribution in the environment owing to the recent industrialization and rapid urbanization in China. In general, Pb from contaminated food, water, and dust enters the body through different channels,spreads throughout the body, combines with multiple amino acids, and interferes with normal physical activity.展开更多
Objective To evaluate the community-based health promotion effect of physical activity. Methods The residents aged 28 and above from two communities in Gongshu District of Hangzhou City, Zhejiang province, were random...Objective To evaluate the community-based health promotion effect of physical activity. Methods The residents aged 28 and above from two communities in Gongshu District of Hangzhou City, Zhejiang province, were randomly selected and recruited for the multi-strategy and comprehensive physical activity intervention. Questionnaire survey, physical check up and blood biochemistry were conducted. Results After this two-year intervention, the time of the participant spent on weekly physical activity of moderate intensity increased from 464 min to 542 min (P〈0.05), with an average increase of 78 min. Time spent in walking every week increased from 533 min to 678 min (P〈0.05), with an average increase of 245 min. The body weight, waistline, blood pressure and heart rate all reduced significantly (P〈0.05); the vital capacity increased significantly (P〈0.05); and the related biochemical indicators were also improved. Conclusion Comprehensive and evidence-based physical activity interventions targeting community population can improve the levels of physical activity, related body measurement and biochemical indicators.展开更多
We assessed the prevalence of non‐ communicable diseases(NCDs) risk factors with a focus on their clustering among healthy adults in Shenzhen, China. Data from the 2011 China Health and Nutrition Survey, comprising...We assessed the prevalence of non‐ communicable diseases(NCDs) risk factors with a focus on their clustering among healthy adults in Shenzhen, China. Data from the 2011 China Health and Nutrition Survey, comprising a regionally representative sample of 806 healthy adults aged 35 years or older, were obtained to determine the prevalence of five risk factors for NCDs. The prevalence of current smoking, central obesity, impaired fasting glucose, borderline hypertension, and borderline high total cholesterol was 19.97%, 28.29%, 4.47%, 10.55%, and 36.10%, respectively. A total 63.77% of participants had at least one risk factor. Upon examination of risk factor clustering, we observed that 7.57% of participants had at least three risk factors. Using this threshold as a cutoff, clustering of risk factors was associated with sex [odds ratio(OR) = 3.336, 95% confidence interval(CI): 1.782 to 6.246], physical activity(OR = 1.913, 95% CI: 1.009 to 3.628), and BMI(OR = 7.376, 95% CI: 3.812 to 14.270). The prevalence of risk factors for NCDs is fairly high among healthy adults in Shenzhen, with a clustering tendency.展开更多
Objective To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal children.Methods Fifty-seven prepubertal children of Beijing were involved in this study and...Objective To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal children.Methods Fifty-seven prepubertal children of Beijing were involved in this study and each subject was orally administered 3 mg of 57 Fe twice daily to obtain a total of 30 mg 57 Fe after a 5-d period. The stable isotope ratios in RBCs were determined in 14 th day, 28 th day, 60 th day, and 90 th day. The erythrocyte incorporation rate in children was calculated using the stable isotope ratios, blood volume and body iron mass.Results The percentage of erythrocyte 57 Fe incorporation increased starting 14 th day, reached a peak at 60 d(boys: 19.67% ± 0.56%, girls: 21.33% ± 0.59%) and then decreased. The erythrocyte incorporation rates of 57 Fe obtained for girls in 60 th day was significantly higher than those obtained for boys(P < 0.0001).Conclusions The oral administration of 57 Fe to children can be used to obtain erythrocyte iron incorporation within 90 d. Prepubertal girls should begin to increase the intake of iron and further studies should pay more attention to the iron status in prepubertal children.展开更多
Objective To determine the dietary zinc absorption in a Chinese elderly population and provide the basic data for the setting of zinc (Zn) recommended nutrient intakes (RNI) for Chinese elderly people. Methods A t...Objective To determine the dietary zinc absorption in a Chinese elderly population and provide the basic data for the setting of zinc (Zn) recommended nutrient intakes (RNI) for Chinese elderly people. Methods A total of 24 elderly people were recruited for this study and were administered oral doses of 3 mg 67Zn and 1.2 mg dysprosium on the fourth day. The primary macronutrients, energy, and phytic acid in the representative diet were examined based on the Chinese National Standard Methods. Fecal samples were collected during the experimenta and dysprosium content. period and analyzed for zinc content, 67Zn isotope ratio, Results The mean (± SD) zinc intake from the representative Chinese diet was 10.6 ± 1.5 mg/d. The phytic acid-to-zinc molar ratio in the diet was 6.4. The absorption rate of 67Zn was 27.9% ±9.2%. The RNI of zinc, which were calculated by the absorption rate in elderly men and women, were 10.4 and 9.2 mg/d, respectively. Conclusion This study got the dietary Zn absorption in a Chinese elderly population. We found that Zn absorption was higher in elderly men than in elderly women. The current RNI in elderly female is lower than our finding, which indicates that more attention is needed regarding elderly females' zinc status and health.展开更多
Iodine is an essential component of thyroid hormones’biosynthesis and is crucial for normal growth and healthy development[1].If the amount of dietary iodine intake cannot match the long-term requirement,regardless o...Iodine is an essential component of thyroid hormones’biosynthesis and is crucial for normal growth and healthy development[1].If the amount of dietary iodine intake cannot match the long-term requirement,regardless of whether it is excessively low or high,it can cause various thyroid dysfunctions,including hyperthyroidism,hypothyroidism,and autoimmune thyroid diseases[2].展开更多
Iron deficiency anemia is one of the most prevalent nutritional deficiency worldwide. The commonly used cut-off values for identifying iron deficiency are extrapolated from older children and may not be suitable for i...Iron deficiency anemia is one of the most prevalent nutritional deficiency worldwide. The commonly used cut-off values for identifying iron deficiency are extrapolated from older children and may not be suitable for infants. Therefore, our study aimed to establish appropriate cut-off values for the evaluation of iron status in Chinese infants. Pregnant women who delivered at 〉37 gestational weeks with normal iron status were recruited. Later, infants with normal birth weight and who were breastfed in the first 4 months were selected. Blood samples were collected to assess hemoglobin, serum ferritin, soluble transferrin receptor, mean corpuscular volume and free erythrocyte protoporphyrin. Cut-offs of all iron indices were determined as the limit of 95% confidence interval.展开更多
Objective This study is to obtain precise data on iron physiological requirements in Chinese children using single stable isotope tracertechnique.Methods Thirty boys(10.6±0.2 years)and 27 girls(10.4±0.2 year...Objective This study is to obtain precise data on iron physiological requirements in Chinese children using single stable isotope tracertechnique.Methods Thirty boys(10.6±0.2 years)and 27 girls(10.4±0.2 years)were received oral 6 mg ^(57)Fe each day for 5 consecutive days.Venous blood samples were subsequently drawn to examine the change of total iron concentration and ^(57)Fe abundance at day 0,14,28,60,90,180,360,450,540,630,720.The iron physiological requirement was calculated by iron loss combined with iron circulation rate once ^(57)Fe abundance stabilized in human body.Results The iron physiological requirement was significantly lower in boys than those values in girls(16.88±7.12 vs.18.40±8.81μg/kg per day,P<0.05).Correspondingly,the values were calculated as 722.46±8.43μg/day for boys and 708.40±7.55μg/day for girls,respectively.Considering nearly 10%iron absorption rate,the estimated average iron physiological requirement was 6.0 mg/day in boys and 6.2 mg/day in girls.Conclusion This study indicate that iron physiological requirement could require more daily iron intake in girls as compare with the values in boys having the same body weight.These findings would be facilitate to the new revised dietary reference intakes.展开更多
Iodine is an element that is essential for the synthesis of thyroid hormones.Adequate intake of dietary iodine has been recognized as a critical factor for maintaining health.It is a well-known fact that iodine defici...Iodine is an element that is essential for the synthesis of thyroid hormones.Adequate intake of dietary iodine has been recognized as a critical factor for maintaining health.It is a well-known fact that iodine deficiency can impede the production of thyroid hormones in both the mother and fetus,which increases the risk of brain damage in the fetal stage.展开更多
Iron deficiency anemia(IDA)is a common nutrient deficiency,and it has become a global public health problem identified by the World Health Organization.Studies have shown that IDA remains prevalent in both developing ...Iron deficiency anemia(IDA)is a common nutrient deficiency,and it has become a global public health problem identified by the World Health Organization.Studies have shown that IDA remains prevalent in both developing and developed countries,such as Australia and China,and that IDA may be associated with poorer cognitive and neurophysiologic maturation in early life and causes labor productivity losses,developmental delays,men tai and behavior disorders,and peri natal complicati ons in pregna nt and preme nopausal women[1].展开更多
基金funded by the National Health Commission of People’s Republic of China Medical Reform Major Program‘2016-2017 National Nutrition and Health Surveillance of Children and Lactating Women’Major Public Health Project‘Survey and Evaluation of Iodine Nutrition and Thyroid Diseases of Chinese Population’[131031107000160007].
文摘Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are limited.This study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum women.Methods A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this study.The urinary iodine concentration(UIC),TSH,VA,and VD were measured.Results The median UIC of total and lactating participants were 142.00µg/L and 139.95µg/L,respectively.The median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,respectively.No differences in the UIC were found between lactating and non-lactating mothers.UIC and TSH levels were significantly different among the three provinces.The rural UIC was higher than the urban UIC.Obese mothers had a higher UIC and a higher prevalence of excessive TSH.Higher UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient group.After adjustment,no linear correlation was observed between UIC and VA/VD.No interaction was found between vitamins A/D and UIC on TSH levels.Conclusion The mothers in the present study had no iodine deficiency.Region,area type,BMI,and VD may be related to the iodine status or TSH levels.
基金sponsored by the Danone Nutrition Fund [Grant no. DIC 2017-06]the Young Scholar Scientific Research Foundation of the Chinese Center for Disease Control and Prevention [Grant No. 2018A204]。
文摘Pb is a well-known toxic metal that has attracted considerable attention because of its ubiquitous distribution in the environment owing to the recent industrialization and rapid urbanization in China. In general, Pb from contaminated food, water, and dust enters the body through different channels,spreads throughout the body, combines with multiple amino acids, and interferes with normal physical activity.
文摘Objective To evaluate the community-based health promotion effect of physical activity. Methods The residents aged 28 and above from two communities in Gongshu District of Hangzhou City, Zhejiang province, were randomly selected and recruited for the multi-strategy and comprehensive physical activity intervention. Questionnaire survey, physical check up and blood biochemistry were conducted. Results After this two-year intervention, the time of the participant spent on weekly physical activity of moderate intensity increased from 464 min to 542 min (P〈0.05), with an average increase of 78 min. Time spent in walking every week increased from 533 min to 678 min (P〈0.05), with an average increase of 245 min. The body weight, waistline, blood pressure and heart rate all reduced significantly (P〈0.05); the vital capacity increased significantly (P〈0.05); and the related biochemical indicators were also improved. Conclusion Comprehensive and evidence-based physical activity interventions targeting community population can improve the levels of physical activity, related body measurement and biochemical indicators.
基金supported by National Project of NCDs High‐risk Population Health Management,Center for Chronic and Non‐communicable Diseases Control and Prevention,China CDC(Grant No.2013085)The Science and Technology Planning Project of Shenzhen City,Guangdong Province,China(Grant No.201602005)
文摘We assessed the prevalence of non‐ communicable diseases(NCDs) risk factors with a focus on their clustering among healthy adults in Shenzhen, China. Data from the 2011 China Health and Nutrition Survey, comprising a regionally representative sample of 806 healthy adults aged 35 years or older, were obtained to determine the prevalence of five risk factors for NCDs. The prevalence of current smoking, central obesity, impaired fasting glucose, borderline hypertension, and borderline high total cholesterol was 19.97%, 28.29%, 4.47%, 10.55%, and 36.10%, respectively. A total 63.77% of participants had at least one risk factor. Upon examination of risk factor clustering, we observed that 7.57% of participants had at least three risk factors. Using this threshold as a cutoff, clustering of risk factors was associated with sex [odds ratio(OR) = 3.336, 95% confidence interval(CI): 1.782 to 6.246], physical activity(OR = 1.913, 95% CI: 1.009 to 3.628), and BMI(OR = 7.376, 95% CI: 3.812 to 14.270). The prevalence of risk factors for NCDs is fairly high among healthy adults in Shenzhen, with a clustering tendency.
基金supported by the National Natural Science Foundation of China grant number 81330066。
文摘Objective To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal children.Methods Fifty-seven prepubertal children of Beijing were involved in this study and each subject was orally administered 3 mg of 57 Fe twice daily to obtain a total of 30 mg 57 Fe after a 5-d period. The stable isotope ratios in RBCs were determined in 14 th day, 28 th day, 60 th day, and 90 th day. The erythrocyte incorporation rate in children was calculated using the stable isotope ratios, blood volume and body iron mass.Results The percentage of erythrocyte 57 Fe incorporation increased starting 14 th day, reached a peak at 60 d(boys: 19.67% ± 0.56%, girls: 21.33% ± 0.59%) and then decreased. The erythrocyte incorporation rates of 57 Fe obtained for girls in 60 th day was significantly higher than those obtained for boys(P < 0.0001).Conclusions The oral administration of 57 Fe to children can be used to obtain erythrocyte iron incorporation within 90 d. Prepubertal girls should begin to increase the intake of iron and further studies should pay more attention to the iron status in prepubertal children.
基金supported by the National Natural Science Foundation of China(No.81273073)
文摘Objective To determine the dietary zinc absorption in a Chinese elderly population and provide the basic data for the setting of zinc (Zn) recommended nutrient intakes (RNI) for Chinese elderly people. Methods A total of 24 elderly people were recruited for this study and were administered oral doses of 3 mg 67Zn and 1.2 mg dysprosium on the fourth day. The primary macronutrients, energy, and phytic acid in the representative diet were examined based on the Chinese National Standard Methods. Fecal samples were collected during the experimenta and dysprosium content. period and analyzed for zinc content, 67Zn isotope ratio, Results The mean (± SD) zinc intake from the representative Chinese diet was 10.6 ± 1.5 mg/d. The phytic acid-to-zinc molar ratio in the diet was 6.4. The absorption rate of 67Zn was 27.9% ±9.2%. The RNI of zinc, which were calculated by the absorption rate in elderly men and women, were 10.4 and 9.2 mg/d, respectively. Conclusion This study got the dietary Zn absorption in a Chinese elderly population. We found that Zn absorption was higher in elderly men than in elderly women. The current RNI in elderly female is lower than our finding, which indicates that more attention is needed regarding elderly females' zinc status and health.
基金supported by the National Natural Science Foundation of China[GN.81872624]the Sanming Project of Medicine in Shenzhen[SZSM201611017]。
文摘Iodine is an essential component of thyroid hormones’biosynthesis and is crucial for normal growth and healthy development[1].If the amount of dietary iodine intake cannot match the long-term requirement,regardless of whether it is excessively low or high,it can cause various thyroid dysfunctions,including hyperthyroidism,hypothyroidism,and autoimmune thyroid diseases[2].
基金supported by Natural Science Foundation of China(Grant No.30972483)The Chinese clinical trial registry number is ChiCTR-TRC-12002838
文摘Iron deficiency anemia is one of the most prevalent nutritional deficiency worldwide. The commonly used cut-off values for identifying iron deficiency are extrapolated from older children and may not be suitable for infants. Therefore, our study aimed to establish appropriate cut-off values for the evaluation of iron status in Chinese infants. Pregnant women who delivered at 〉37 gestational weeks with normal iron status were recruited. Later, infants with normal birth weight and who were breastfed in the first 4 months were selected. Blood samples were collected to assess hemoglobin, serum ferritin, soluble transferrin receptor, mean corpuscular volume and free erythrocyte protoporphyrin. Cut-offs of all iron indices were determined as the limit of 95% confidence interval.
基金supported by the National Natural Science Foundation of China [grant number 81330066]
文摘Objective This study is to obtain precise data on iron physiological requirements in Chinese children using single stable isotope tracertechnique.Methods Thirty boys(10.6±0.2 years)and 27 girls(10.4±0.2 years)were received oral 6 mg ^(57)Fe each day for 5 consecutive days.Venous blood samples were subsequently drawn to examine the change of total iron concentration and ^(57)Fe abundance at day 0,14,28,60,90,180,360,450,540,630,720.The iron physiological requirement was calculated by iron loss combined with iron circulation rate once ^(57)Fe abundance stabilized in human body.Results The iron physiological requirement was significantly lower in boys than those values in girls(16.88±7.12 vs.18.40±8.81μg/kg per day,P<0.05).Correspondingly,the values were calculated as 722.46±8.43μg/day for boys and 708.40±7.55μg/day for girls,respectively.Considering nearly 10%iron absorption rate,the estimated average iron physiological requirement was 6.0 mg/day in boys and 6.2 mg/day in girls.Conclusion This study indicate that iron physiological requirement could require more daily iron intake in girls as compare with the values in boys having the same body weight.These findings would be facilitate to the new revised dietary reference intakes.
基金sponsored by the Young Scholar Scientific Research Foundation of the National Institute of Nutrition and Health of China CDC[Grant No:NINH2016001]
文摘Iodine is an element that is essential for the synthesis of thyroid hormones.Adequate intake of dietary iodine has been recognized as a critical factor for maintaining health.It is a well-known fact that iodine deficiency can impede the production of thyroid hormones in both the mother and fetus,which increases the risk of brain damage in the fetal stage.
基金the Dietary Nutrition Research and Education Foundation of the Danone Nutrition Center[DIC2014-09].
文摘Iron deficiency anemia(IDA)is a common nutrient deficiency,and it has become a global public health problem identified by the World Health Organization.Studies have shown that IDA remains prevalent in both developing and developed countries,such as Australia and China,and that IDA may be associated with poorer cognitive and neurophysiologic maturation in early life and causes labor productivity losses,developmental delays,men tai and behavior disorders,and peri natal complicati ons in pregna nt and preme nopausal women[1].