目的:本研究基于中性粒细胞与淋巴细胞比值(neutrophils to lymphocytes ratio,NLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)及淋巴细胞与单核细胞比值(lymphocyte to monocyte ratio,LMR)构建预测HCC肝切除术后患者...目的:本研究基于中性粒细胞与淋巴细胞比值(neutrophils to lymphocytes ratio,NLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)及淋巴细胞与单核细胞比值(lymphocyte to monocyte ratio,LMR)构建预测HCC肝切除术后患者生存率的炎症反应评分(inflammatory response score,IRS)。方法:选取北京朝阳急诊抢救中心、空军特色医学中心在2013年5月至2019年1月收治的284例肝细胞癌(hepatocellular carcinoma,HCC)患者。采用ROC曲线获得NLR、PLR、LMR最佳截断值并构建NPL-IRS。通过时间-ROC评价NPL-IRS的有效性。结果:284例患者随访时间3~43个月,随访(21.52±7.98)个月。随访末期,157例患者死亡,1年病死率24.6%、3年病死率55.3%。NLR、PLR、LMR的AUC分别为0.889、0.895、0.861;最佳截断值分别为2.34、98.74、3.43。NLR≤2.34、PLR≤98.74、LMR>3.43组患者的总体生存率高于对应组别(P<0.05)。肝硬化、多发肿瘤、血管侵犯、Ⅲ~Ⅳ期肿瘤、NPL-IRS-1分、NPL-IRS-2分、NPL-IRS-3分是HCC患者死亡的独立危险因素(P<0.05)。NPL-IRS的最佳截断值为1,AUC为0.794(95%CI=0.742~0.839)。时间-ROC曲线结果显示:NPL-IRS的AUC在任何时间段均高于NLR、PLR、LMR。结论:基于NLR、PLR、LMR最佳截断值成功构建出NPL-IRS,该评分系统较单一的炎症反应标准物更能准确预测HCC患者预后。展开更多
Rhenium separation from molybdenum in molybdenite minerals and waste leachate has become an emerging challenge.Addressing this challenge,we prepared a set of protein-based alkylamine/alkylammonium salts complexes as e...Rhenium separation from molybdenum in molybdenite minerals and waste leachate has become an emerging challenge.Addressing this challenge,we prepared a set of protein-based alkylamine/alkylammonium salts complexes as extractants for selective uptake of rhenium from molybdenum,where the protein component turned into the insoluble amyloid-like structure when its internal disulfide bonds were reduced,namely phase-transition process.Among them,the phase-transited lysozyme and methyletrioctyleammonium chloride complex(PTL-N263)exhibited the most efficient adsorption at the alkaline condition for the electrostatic interaction between negatively charged metal ions with positively charged center(R_(4)N^(+))in N263,where negatively charged protein residues hindered the ion exchange of Cl^(-)in N263 for larger size Mo species(Mo_(7)O_(24)^(6-))than smaller size Re species(ReO^(4-)).The adsorption follows the Freundlich model and pseudo-second-order kinetics,which exhibits toplevel adsorption performance with a maximum adsorption capacity of 124 mg/g and a separation factor(β_(Re/Mo))of 2.78×10^(3)for Re.The adsorption capacity per unit area(57.2 mg/(g m^(2)))is 1.6–41 times higher than previously reported adsorbents,and the cost for adsorbing 1 g of Re(VII)is$1.07,indicating its industrial capability.This adsorption strategy can be applied to separating Re from Mo in binary solutions and industrial wastewater with other competing ions.展开更多
目的构建适合中国ICU浅镇静患者非药物睡眠干预方案,以提高ICU浅镇静患者的睡眠质量.方法检索国内外数据库获取ICU患者睡眠管理相关的证据,采用Jonna Briggs Institute 2010证据等级与推荐工具对证据进行分级和推荐,初拟ICU浅镇静患者...目的构建适合中国ICU浅镇静患者非药物睡眠干预方案,以提高ICU浅镇静患者的睡眠质量.方法检索国内外数据库获取ICU患者睡眠管理相关的证据,采用Jonna Briggs Institute 2010证据等级与推荐工具对证据进行分级和推荐,初拟ICU浅镇静患者非药物睡眠干预方案,通过德尔菲法将方案本土化.结果构建的ICU浅镇静患者非药物睡眠干预方案包括实施的前提条件、ICU浅镇静患者非药物睡眠干预方案的构成及具体实施方法2个部分、11个维度、30条实施策略.结论基于循证和德尔菲法构建的ICU浅镇静患者睡眠干预方案具有科学性和实用性,可用于临床ICU患者的睡眠管理.展开更多
文摘目的:本研究基于中性粒细胞与淋巴细胞比值(neutrophils to lymphocytes ratio,NLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)及淋巴细胞与单核细胞比值(lymphocyte to monocyte ratio,LMR)构建预测HCC肝切除术后患者生存率的炎症反应评分(inflammatory response score,IRS)。方法:选取北京朝阳急诊抢救中心、空军特色医学中心在2013年5月至2019年1月收治的284例肝细胞癌(hepatocellular carcinoma,HCC)患者。采用ROC曲线获得NLR、PLR、LMR最佳截断值并构建NPL-IRS。通过时间-ROC评价NPL-IRS的有效性。结果:284例患者随访时间3~43个月,随访(21.52±7.98)个月。随访末期,157例患者死亡,1年病死率24.6%、3年病死率55.3%。NLR、PLR、LMR的AUC分别为0.889、0.895、0.861;最佳截断值分别为2.34、98.74、3.43。NLR≤2.34、PLR≤98.74、LMR>3.43组患者的总体生存率高于对应组别(P<0.05)。肝硬化、多发肿瘤、血管侵犯、Ⅲ~Ⅳ期肿瘤、NPL-IRS-1分、NPL-IRS-2分、NPL-IRS-3分是HCC患者死亡的独立危险因素(P<0.05)。NPL-IRS的最佳截断值为1,AUC为0.794(95%CI=0.742~0.839)。时间-ROC曲线结果显示:NPL-IRS的AUC在任何时间段均高于NLR、PLR、LMR。结论:基于NLR、PLR、LMR最佳截断值成功构建出NPL-IRS,该评分系统较单一的炎症反应标准物更能准确预测HCC患者预后。
基金supported by the National Science Fund for Distinguished Young Scholars(Grant No.52225301)the National Key R&D Program of China(Grant Nos.2020YFA0710400 and 2020YFA0710402)+5 种基金the National Natural Science Foundation of China(Grant Nos.21905166,2187513251903147)the 111 Project(Grant No.B14041)the Fundamental Research Funds for the Central Universities(Grant Nos.GK201801003,2020TS092,and GK202205013)the Innovation Capability Support Program of Shaanxi(Grant No.2020TD024)the Science and Technology Innovation Team of Shaanxi Province(Grant No.2022TD-35)。
文摘Rhenium separation from molybdenum in molybdenite minerals and waste leachate has become an emerging challenge.Addressing this challenge,we prepared a set of protein-based alkylamine/alkylammonium salts complexes as extractants for selective uptake of rhenium from molybdenum,where the protein component turned into the insoluble amyloid-like structure when its internal disulfide bonds were reduced,namely phase-transition process.Among them,the phase-transited lysozyme and methyletrioctyleammonium chloride complex(PTL-N263)exhibited the most efficient adsorption at the alkaline condition for the electrostatic interaction between negatively charged metal ions with positively charged center(R_(4)N^(+))in N263,where negatively charged protein residues hindered the ion exchange of Cl^(-)in N263 for larger size Mo species(Mo_(7)O_(24)^(6-))than smaller size Re species(ReO^(4-)).The adsorption follows the Freundlich model and pseudo-second-order kinetics,which exhibits toplevel adsorption performance with a maximum adsorption capacity of 124 mg/g and a separation factor(β_(Re/Mo))of 2.78×10^(3)for Re.The adsorption capacity per unit area(57.2 mg/(g m^(2)))is 1.6–41 times higher than previously reported adsorbents,and the cost for adsorbing 1 g of Re(VII)is$1.07,indicating its industrial capability.This adsorption strategy can be applied to separating Re from Mo in binary solutions and industrial wastewater with other competing ions.
文摘目的构建适合中国ICU浅镇静患者非药物睡眠干预方案,以提高ICU浅镇静患者的睡眠质量.方法检索国内外数据库获取ICU患者睡眠管理相关的证据,采用Jonna Briggs Institute 2010证据等级与推荐工具对证据进行分级和推荐,初拟ICU浅镇静患者非药物睡眠干预方案,通过德尔菲法将方案本土化.结果构建的ICU浅镇静患者非药物睡眠干预方案包括实施的前提条件、ICU浅镇静患者非药物睡眠干预方案的构成及具体实施方法2个部分、11个维度、30条实施策略.结论基于循证和德尔菲法构建的ICU浅镇静患者睡眠干预方案具有科学性和实用性,可用于临床ICU患者的睡眠管理.
